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Index Lonaprisan

Lonaprisan (INN, USAN) (developmental code names ZK-230211, BAY 86-5044, ZK-PRA) is a synthetic, steroidal antiprogestogen which was under development by Bayer HealthCare Pharmaceuticals for the treatment of endometriosis, dysmenorrhea, and breast cancer but was discontinued. [1]

19 relations: Antiprogestogen, Bayer, Binding selectivity, Breast cancer, Clinical trial, Dysmenorrhea, Endometriosis, International nonproprietary name, Mifepristone, Onapristone, Oral administration, Organic compound, Potency (pharmacology), Progesterone receptor, Receptor antagonist, Steroid, Ulipristal acetate, United States Adopted Name, Vilaprisan.


Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body.

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Bayer AG is a German multinational, pharmaceutical and life sciences company.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Dysmenorrhea, also known as painful periods, or menstrual cramps, is pain during menstruation.

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Endometriosis is a condition in which the endometrium, the layer of tissue that normally covers the inside of the uterus, grows outside of it.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol, to bring about an abortion.

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Onapristone (INN) (developmental code names ZK-89299, ZK-299) is a synthetic, steroidal antiprogestogen with additional antiglucocorticoid activity which was developed by Schering and described in 1984 but was never marketed.

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Oral administration

| name.

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Organic compound

In chemistry, an organic compound is generally any chemical compound that contains carbon.

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Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

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Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

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Ulipristal acetate

Ulipristal acetate, sold under the brand name Ella among others, is a medication used for emergency birth control and uterine fibroids.

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United States Adopted Name

United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.

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Vilaprisan (INN, USAN) (developmental code name BAY-1002670) is a synthetic, steroidal selective progesterone receptor modulator (SPRM) which is under development by Bayer HealthCare Pharmaceuticals for the treatment of endometriosis and uterine fibroids.

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Redirects here:

BAY 86-5044, BAY 865044, BAY-86-5044, BAY-865044, BAY86-5044, BAY865044, Lonaprisal, ZK 230,211, ZK 230211, ZK-230,211, ZK-230211, ZK-PRA, ZK230211.


[1] https://en.wikipedia.org/wiki/Lonaprisan

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