Get it on Google Play
New! Download Unionpedia on your Android™ device!
Faster access than browser!


Index Loperamide

Loperamide, sold under the brand name Imodium among others, is a medication used to decrease the frequency of diarrhea. [1]

89 relations: Abdominal distension, Adverse drug reaction, Agonist, Angioedema, Anticholinergic, Antihistamine, Antipsychotic, Beerse, Bloating, Blood–brain barrier, Breastfeeding, British Society of Gastroenterology, Cardiotoxicity, Clostridium difficile infection, Constipation, Contraindication, Developing country, Diarrhea, Diphenoxylate, Dysentery, Enterocolitis, Erythema multiforme, Escherichia coli O157:H7, Fentanyl, Fever, First pass effect, Food and Drug Administration, Gastrocolic reflex, Gastroenteritis, Gastrointestinal tract, Generic drug, Gut (journal), Health system, Heart arrhythmia, Heat stroke, HIV, Ileostomy, Ileus, Inflammatory bowel disease, Irinotecan, Μ-opioid receptor, Janssen Pharmaceutica, Johnson & Johnson, Journal of Medicinal Chemistry, Ketoconazole, Liver, Liver failure, Loperamide/simethicone, Methadone, Methylnaltrexone, ..., Morphine, MPTP, Myenteric plexus, Naloxegol, Off-label use, Opioid, Opioid epidemic, Orally disintegrating tablet, Ortho-McNeil Pharmaceutical, Over-the-counter drug, P-glycoprotein, Pakistan, Paul Janssen, Peripheral nervous system, Physical dependence, Placebo, Pregnancy, Pregnancy category, Pseudoephedrine, Quinidine, Ritonavir, Salmonella, Saquinavir, Short bowel syndrome, Simeticone, Smooth muscle tissue, Stevens–Johnson syndrome, Teratology, Toxic epidermal necrolysis, Toxic megacolon, Traveler's diarrhea, Ulcerative colitis, United Kingdom, United Nations, United States dollar, Urinary retention, WHO Model List of Essential Medicines, World Health Organization, Zydis. Expand index (39 more) »

Abdominal distension

Abdominal distension occurs when substances, such as air (gas) or fluid, accumulate in the abdomen causing its outward expansion beyond the normal girth of the stomach and waist.

New!!: Loperamide and Abdominal distension · See more »

Adverse drug reaction

An adverse drug reaction (ADR) is an injury caused by taking a medication.

New!!: Loperamide and Adverse drug reaction · See more »


An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

New!!: Loperamide and Agonist · See more »


Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes.

New!!: Loperamide and Angioedema · See more »


An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.

New!!: Loperamide and Anticholinergic · See more »


Antihistamines are drugs which treat allergic rhinitis and other allergies.

New!!: Loperamide and Antihistamine · See more »


Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.

New!!: Loperamide and Antipsychotic · See more »


Beerse is a municipality located in the Belgian province of Antwerp.

New!!: Loperamide and Beerse · See more »


Abdominal bloating is a symptom that can appear at any age, generally associated with functional gastrointestinal disorders or organic diseases, but can also appear alone.

New!!: Loperamide and Bloating · See more »

Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).

New!!: Loperamide and Blood–brain barrier · See more »


Breastfeeding, also known as nursing, is the feeding of babies and young children with milk from a woman's breast.

New!!: Loperamide and Breastfeeding · See more »

British Society of Gastroenterology

The British Society of Gastroenterology (BSG) is a British professional organisation of gastroenterologists, surgeons, pathologists, radiologists, scientists, nurses, dietitians and others amongst its members, which number over 3,000.

New!!: Loperamide and British Society of Gastroenterology · See more »


Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage.

New!!: Loperamide and Cardiotoxicity · See more »

Clostridium difficile infection

Clostridium difficile infection (CDI or C-dif) is a symptomatic infection due to the spore-forming bacterium, Clostridium difficile.

New!!: Loperamide and Clostridium difficile infection · See more »


Constipation refers to bowel movements that are infrequent or hard to pass.

New!!: Loperamide and Constipation · See more »


In medicine, a contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient.

New!!: Loperamide and Contraindication · See more »

Developing country

A developing country (or a low and middle income country (LMIC), less developed country, less economically developed country (LEDC), underdeveloped country) is a country with a less developed industrial base and a low Human Development Index (HDI) relative to other countries.

New!!: Loperamide and Developing country · See more »


Diarrhea, also spelled diarrhoea, is the condition of having at least three loose or liquid bowel movements each day.

New!!: Loperamide and Diarrhea · See more »


Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used in a combination drug with atropine for the treatment of diarrhea.

New!!: Loperamide and Diphenoxylate · See more »


Dysentery is an inflammatory disease of the intestine, especially of the colon, which always results in severe diarrhea and abdominal pains.

New!!: Loperamide and Dysentery · See more »


Enterocolitis or coloenteritis is an inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon.

New!!: Loperamide and Enterocolitis · See more »

Erythema multiforme

Erythema multiforme (EM) is a skin condition of unknown cause; it is a type of erythema possibly mediated by deposition of immune complexes (mostly IgM-bound complexes) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure.

New!!: Loperamide and Erythema multiforme · See more »

Escherichia coli O157:H7

Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga toxin–producing types of E. coli.

New!!: Loperamide and Escherichia coli O157:H7 · See more »


Fentanyl, also spelled fentanil, is an opioid which is used as a pain medication and together with other medications for anesthesia. Fentanyl is also made illegally and used as a recreational drug, often mixed with heroin or cocaine. It has a rapid onset and effects generally last less than an hour or two. Medically, fentanyl is used by injection, as a patch on the skin, as a nasal spray, or in the mouth. Common side effects include vomiting, constipation, sedation, confusion, hallucinations, and injuries related to poor coordination. Serious side effects may include decreased breathing (respiratory depression), serotonin syndrome, low blood pressure, addiction, or coma. In 2016, more than 20,000 deaths occurred in the United States due to overdoses of fentanyl and fentanyl analogues, half of all reported opioid related deaths. Fentanyl works primarily by activating μ-opioid receptors. It is around 100 times stronger than morphine, and some analogues such as carfentanil are around 10,000 times stronger. Fentanyl was first made by Paul Janssen in 1960 and approved for medical use in the United States in 1968.In 2015, were used in healthcare globally., fentanyl was the most widely used synthetic opioid in medicine. Fentanyl patches are on the WHO List of Essential Medicines, the most effective and safe medicines needed in a health system. For a 100 microgram vial, the average wholesale cost in the developing world is 0.66 (2015). and in the USA it costs 0.49 (2017).

New!!: Loperamide and Fentanyl · See more »


Fever, also known as pyrexia and febrile response, is defined as having a temperature above the normal range due to an increase in the body's temperature set-point.

New!!: Loperamide and Fever · See more »

First pass effect

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.

New!!: Loperamide and First pass effect · See more »

Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

New!!: Loperamide and Food and Drug Administration · See more »

Gastrocolic reflex

The gastrocolic reflex or gastrocolic response is one of a number of physiological reflexes controlling the motility, or peristalsis, of the gastrointestinal tract.

New!!: Loperamide and Gastrocolic reflex · See more »


Gastroenteritis, also known as infectious diarrhea, is inflammation of the gastrointestinal tract -- the stomach and small intestine.

New!!: Loperamide and Gastroenteritis · See more »

Gastrointestinal tract

The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.

New!!: Loperamide and Gastrointestinal tract · See more »

Generic drug

A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.

New!!: Loperamide and Generic drug · See more »

Gut (journal)

Gut is a monthly peer-reviewed medical journal on gastroenterology and hepatology.

New!!: Loperamide and Gut (journal) · See more »

Health system

A health system, also sometimes referred to as health care system or as healthcare system, is the organization of people, institutions, and resources that deliver health care services to meet the health needs of target populations.

New!!: Loperamide and Health system · See more »

Heart arrhythmia

Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.

New!!: Loperamide and Heart arrhythmia · See more »

Heat stroke

Heat stroke, also known as sun stroke, is a type of severe heat illness that results in a body temperature greater than and confusion.

New!!: Loperamide and Heat stroke · See more »


The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

New!!: Loperamide and HIV · See more »


Ileostomy is a stoma (surgical opening) constructed by bringing the end or loop of small intestine (the ileum) out onto the surface of the skin, or the surgical procedure which creates this opening.

New!!: Loperamide and Ileostomy · See more »


Ileus is a disruption of the normal propulsive ability of the gastrointestinal tract.

New!!: Loperamide and Ileus · See more »

Inflammatory bowel disease

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine.

New!!: Loperamide and Inflammatory bowel disease · See more »


Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer.

New!!: Loperamide and Irinotecan · See more »

Μ-opioid receptor

The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins.

New!!: Loperamide and Μ-opioid receptor · See more »

Janssen Pharmaceutica

Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium.

New!!: Loperamide and Janssen Pharmaceutica · See more »

Johnson & Johnson

Johnson & Johnson is an American multinational medical devices, pharmaceutical and consumer packaged goods manufacturing company founded in 1886.

New!!: Loperamide and Johnson & Johnson · See more »

Journal of Medicinal Chemistry

The Journal of Medicinal Chemistry is a peer-reviewed medical journal covering research in medicinal chemistry.

New!!: Loperamide and Journal of Medicinal Chemistry · See more »


Ketoconazole is a synthetic imidazole antifungal drug used primarily to treat fungal infections.

New!!: Loperamide and Ketoconazole · See more »


The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

New!!: Loperamide and Liver · See more »

Liver failure

Liver failure or hepatic insufficiency is the inability of the liver to perform its normal synthetic and metabolic function as part of normal physiology.

New!!: Loperamide and Liver failure · See more »


Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously.

New!!: Loperamide and Loperamide/simethicone · See more »


Methadone, sold under the brand name Dolophine among others, is an opioid used to treat pain and as maintenance therapy or to help with tapering in people with opioid dependence.

New!!: Loperamide and Methadone · See more »


Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is one of the newer agents of peripherally acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals.

New!!: Loperamide and Methylnaltrexone · See more »


Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.

New!!: Loperamide and Morphine · See more »


MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain.

New!!: Loperamide and MPTP · See more »

Myenteric plexus

The myenteric plexus (or Auerbach's plexus) provides motor innervation to both layers of the muscular layer of the gut, having both parasympathetic and sympathetic input (although present ganglionar cell bodies belong to parasympathetic innervation, fibers from sympathetic innervation also reach the plexus), whereas the submucous plexus has only parasympathetic fibers and provides secretomotor innervation to the mucosa nearest the lumen of the gut.

New!!: Loperamide and Myenteric plexus · See more »


Naloxegol (INN; PEGylated naloxol; trade names Movantik and Moventig) is a peripherally selective opioid antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation.

New!!: Loperamide and Naloxegol · See more »

Off-label use

Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.

New!!: Loperamide and Off-label use · See more »


Opioids are substances that act on opioid receptors to produce morphine-like effects.

New!!: Loperamide and Opioid · See more »

Opioid epidemic

The opioid epidemic or opioid crisis is the rapid increase in the use of prescription and non-prescription opioid drugs in the United States and Canada beginning in the late 1990s and continuing throughout the next two decades.

New!!: Loperamide and Opioid epidemic · See more »

Orally disintegrating tablet

An orally disintegrating tablet or orally dissolving tablet (ODT) is a drug dosage form available for a limited range of over-the-counter (OTC) and prescription medications.

New!!: Loperamide and Orally disintegrating tablet · See more »

Ortho-McNeil Pharmaceutical

The company was formed from the merger of Ortho Pharmaceutical and McNeil Pharmaceutical in 1993.

New!!: Loperamide and Ortho-McNeil Pharmaceutical · See more »

Over-the-counter drug

Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a prescription from a healthcare professional, as opposed to prescription drugs, which may be sold only to consumers possessing a valid prescription.

New!!: Loperamide and Over-the-counter drug · See more »


P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.

New!!: Loperamide and P-glycoprotein · See more »


Pakistan (پاکِستان), officially the Islamic Republic of Pakistan (اِسلامی جمہوریہ پاکِستان), is a country in South Asia.

New!!: Loperamide and Pakistan · See more »

Paul Janssen

Paul Adriaan Jan, Baron Janssen (12 September 1926, Turnhout – 11 November 2003, Rome) was a Belgian physician.

New!!: Loperamide and Paul Janssen · See more »

Peripheral nervous system

The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).

New!!: Loperamide and Peripheral nervous system · See more »

Physical dependence

Physical dependence is a physical condition caused by chronic use of a tolerance forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms.

New!!: Loperamide and Physical dependence · See more »


A placebo is a substance or treatment of no intended therapeutic value.

New!!: Loperamide and Placebo · See more »


Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.

New!!: Loperamide and Pregnancy · See more »

Pregnancy category

The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy.

New!!: Loperamide and Pregnancy category · See more »


Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes.

New!!: Loperamide and Pseudoephedrine · See more »


Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart.

New!!: Loperamide and Quinidine · See more »


Ritonavir, sold under the trade name Norvir, is an antiretroviral medication used along with other medications to treat HIV/AIDS.

New!!: Loperamide and Ritonavir · See more »


Salmonella is a genus of rod-shaped (bacillus) Gram-negative bacteria of the family Enterobacteriaceae.

New!!: Loperamide and Salmonella · See more »


Saquinavir, sold under the brand names Invirase and Fortovase, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.

New!!: Loperamide and Saquinavir · See more »

Short bowel syndrome

Short bowel syndrome (SBS, or simply short gut) is a malabsorption disorder caused by a lack of functional small intestine.

New!!: Loperamide and Short bowel syndrome · See more »


Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.

New!!: Loperamide and Simeticone · See more »

Smooth muscle tissue

Smooth muscle is an involuntary non-striated muscle.

New!!: Loperamide and Smooth muscle tissue · See more »

Stevens–Johnson syndrome

Stevens–Johnson syndrome (SJS) is a type of severe skin reaction.

New!!: Loperamide and Stevens–Johnson syndrome · See more »


Teratology is the study of abnormalities of physiological development.

New!!: Loperamide and Teratology · See more »

Toxic epidermal necrolysis

Toxic epidermal necrolysis (TEN) is a type of severe skin reaction.

New!!: Loperamide and Toxic epidermal necrolysis · See more »

Toxic megacolon

Toxic megacolon (megacolon toxicum) is an acute form of colonic distension.

New!!: Loperamide and Toxic megacolon · See more »

Traveler's diarrhea

Traveler's diarrhea (TD) is a stomach and intestinal infection.

New!!: Loperamide and Traveler's diarrhea · See more »

Ulcerative colitis

Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum.

New!!: Loperamide and Ulcerative colitis · See more »

United Kingdom

The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.

New!!: Loperamide and United Kingdom · See more »

United Nations

The United Nations (UN) is an intergovernmental organization tasked to promote international cooperation and to create and maintain international order.

New!!: Loperamide and United Nations · See more »

United States dollar

The United States dollar (sign: $; code: USD; also abbreviated US$ and referred to as the dollar, U.S. dollar, or American dollar) is the official currency of the United States and its insular territories per the United States Constitution since 1792.

New!!: Loperamide and United States dollar · See more »

Urinary retention

Urinary retention is an inability to completely empty the bladder.

New!!: Loperamide and Urinary retention · See more »

WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.

New!!: Loperamide and WHO Model List of Essential Medicines · See more »

World Health Organization

The World Health Organization (WHO; French: Organisation mondiale de la santé) is a specialized agency of the United Nations that is concerned with international public health.

New!!: Loperamide and World Health Organization · See more »


Zydis is a technology used to manufacture orally disintegrating tablets developed by R.P. Scherer Corporation.

New!!: Loperamide and Zydis · See more »

Redirects here:

ATC code A07DA03, ATCvet code QA07DA03, Apo-Loperamide, C29H33ClN2O2, Diarr-Eze, Dimor, Immodium, Imodium, Imodium A-D, Imodium A-D Caplets, Imodium AD, Imodium a-d, Ioperamide, Kaopectate II, Loperacap, Loperamid, Loperamida, Loperamide HCI, Loperamide Hydrochloride, Loperamide hcl, Loperamide hydrochloride, Loperamidum, Lopex, Maalox Anti-Diarrheal, Norimode, Nu-Loperamide, PMS-Loperamide, Pepto Diarrhea Control, R 18 553, R 18-553, R 18553, R-18 553, R-18-553, R-18553, R18 553, R18-553, R18553, Rho-Loperamide, Travello, Vaprino.


[1] https://en.wikipedia.org/wiki/Loperamide

Hey! We are on Facebook now! »