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Index Lysin

Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. [1]

32 relations: Antibiotic, Archaea, Autolysis (biology), Bacterial outer membrane, Bacteriophage, C-terminus, Cell wall, Cytokine release syndrome, Endopeptidase, Enzybiotics, Gram-negative bacteria, Gram-positive bacteria, Holin, Hydrolase, Lysozyme, Lytic cycle, Microbiota, Mucous membrane, N-Acetylglucosamine, N-Acetylmuramic acid, N-acetylmuramoyl-L-alanine amidase, N-terminus, OBPgp279, Peptidoglycan, Phage therapy, Protein Data Bank, Protein domain, Pseudopeptidoglycan, Signal peptide, Streptococcus pyogenes, Unified atomic mass unit, Virus.


An antibiotic (from ancient Greek αντιβιοτικά, antibiotiká), also called an antibacterial, is a type of antimicrobial drug used in the treatment and prevention of bacterial infections.

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Archaea (or or) constitute a domain of single-celled microorganisms.

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Autolysis (biology)

In biology, autolysis, more commonly known as self-digestion, refers to the destruction of a cell through the action of its own enzymes.

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Bacterial outer membrane

The bacterial outer membrane is found in gram-negative bacteria.

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A bacteriophage, also known informally as a phage, is a virus that infects and replicates within Bacteria and Archaea.

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The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Cell wall

A cell wall is a structural layer surrounding some types of cells, just outside the cell membrane.

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Cytokine release syndrome

Cytokine release syndrome is a form of systemic inflammatory response syndrome that arises as a complication of some diseases or infections, and is also an adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies.

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Endopeptidase or endoproteinase are proteolytic peptidases that break peptide bonds of nonterminal amino acids (i.e. within the molecule), in contrast to exopeptidases, which break peptide bonds from end-pieces of terminal amino acids.

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Enzybiotics are an experimental antibiotic approach employing enzymes to combat pathogenic bacterial infections.

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Gram-negative bacteria

Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the gram-staining method of bacterial differentiation.

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Gram-positive bacteria

Gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their cell wall.

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Holins are a diverse group of small proteins produced by dsDNA bacteriophages in order to trigger and control the degradation of the host's cell wall at the end of the lytic cycle.

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Hydrolase is a class of enzyme that is commonly used as biochemical catalysts that utilize water to break a chemical bond.

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Lysozyme, also known as muramidase or N-acetylmuramide glycanhydrolase is an antimicrobial enzyme produced by animals that forms part of the innate immune system.

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Lytic cycle

The lytic cycle is one of the two cycles of viral reproduction (referring to bacterial viruses or bacteriophages), the other being the lysogenic cycle.

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A microbiota is an "ecological community of commensal, symbiotic and pathogenic microorganisms" found in and on all multicellular organisms studied to date from plants to animals.

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Mucous membrane

A mucous membrane or mucosa is a membrane that lines various cavities in the body and covers the surface of internal organs.

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N-Acetylglucosamine (N-acetyl-D-glucosamine, or GlcNAc, or NAG) is a monosaccharide and a derivative of glucose.

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N-Acetylmuramic acid

N-Acetylmuramic acid, or MurNAc, is the ether of lactic acid and ''N''-acetylglucosamine with a chemical formula of C11H19NO8.

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N-acetylmuramoyl-L-alanine amidase

In enzymology, a N-acetylmuramoyl-L-alanine amidase is an enzyme that catalyzes a chemical reaction that cleaves the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

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The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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OBPgp279 is an endolysin that hydrolyzes peptidoglycan, a major constituent in bacterial membrane.

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Peptidoglycan, also known as murein, is a polymer consisting of sugars and amino acids that forms a mesh-like layer outside the plasma membrane of most bacteria, forming the cell wall.

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Phage therapy

Phage therapy or viral phage therapy is the therapeutic use of bacteriophages to treat pathogenic bacterial infections.

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Protein Data Bank

The Protein Data Bank (PDB) is a crystallographic database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Pseudopeptidoglycan (also known as pseudomureinWhite, David. (1995) The Physiology and Biochemistry of Prokaryotes, pages 6, 12-21. (Oxford: Oxford University Press)..) is a major cell wall component of some Archaea that differs from bacterial peptidoglycan in chemical structure, but resembles bacterial peptidoglycan in function and physical structure.

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Signal peptide

A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long) present at the N-terminus of the majority of newly synthesized proteins that are destined towards the secretory pathway.

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Streptococcus pyogenes

Streptococcus pyogenes is a species of Gram-positive bacteria.

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Unified atomic mass unit

The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).

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A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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Endolysin, Endolysins, Lysins, Murein hydrolase, Murein hydrolases, Phage lysin.


[1] https://en.wikipedia.org/wiki/Lysin

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