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Löffler's syndrome

Index Löffler's syndrome

Löffler's syndrome or Loeffler's syndrome is a disease in which eosinophils accumulate in the lung in response to a parasitic infection. [1]

15 relations: Ancylostoma duodenale, Ascaris lumbricoides, Disease, Eosinophil, Eosinophilic pneumonia, Hookworm infection, Loeffler endocarditis, Lung, Major basic protein, Necator americanus, Parasitic pneumonia, Parasitism, Pneumonia, Strongyloides stercoralis, Wilhelm Löffler (doctor).

Ancylostoma duodenale

Ancylostoma duodenale is a species of the roundworm genus Ancylostoma.

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Ascaris lumbricoides

Ascaris lumbricoides is the "large roundworm" of humans, growing to a length of up to.

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Disease

A disease is any condition which results in the disorder of a structure or function in an organism that is not due to any external injury.

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Eosinophil

Eosinophils sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply. These cells are eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes: Normally transparent, it is this affinity that causes them to appear brick-red after staining with eosin, a red dye, using the Romanowsky method. The staining is concentrated in small granules within the cellular cytoplasm, which contain many chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite and host tissues. In normal individuals, eosinophils make up about 1–3% of white blood cells, and are about 12–17 micrometres in size with bilobed nuclei. While they are released into the bloodstream as neutrophils are, eosinophils reside in tissue They are found in the medulla and the junction between the cortex and medulla of the thymus, and, in the lower gastrointestinal tract, ovary, uterus, spleen, and lymph nodes, but not in the lung, skin, esophagus, or some other internal organs under normal conditions. The presence of eosinophils in these latter organs is associated with disease. For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments.

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Eosinophilic pneumonia

Eosinophilic pneumonia (EP) is a disease in which an eosinophil, a type of white blood cell, accumulates in the lung.

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Hookworm infection

Hookworm infection is an infection by a type of intestinal parasite in the roundworm group.

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Loeffler endocarditis

Loeffler endocarditis is a form of restrictive cardiomyopathy caused by infiltration of the heart by white blood cells known as eosinophils.

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Lung

The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.

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Major basic protein

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), also known as PRG2, is a protein which in humans is encoded by the PRG2 gene.

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Necator americanus

Necator americanus is a species of hookworm (a type of helminth) commonly known as the New World hookworm.

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Parasitic pneumonia

Parasitic pneumonia is an infection of the lungs by parasites.

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Parasitism

In evolutionary biology, parasitism is a relationship between species, where one organism, the parasite, lives on or in another organism, the host, causing it some harm, and is adapted structurally to this way of life.

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Pneumonia

Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli.

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Strongyloides stercoralis

Strongyloides stercoralis is a human pathogenic parasitic roundworm causing the disease strongyloidiasis.

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Wilhelm Löffler (doctor)

Wilhelm Löffler (28 June 1887 – 25 November 1972) was a Swiss doctor.

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Redirects here:

Loeffler Syndrome, Loeffler's disease, Loeffler's syndrome, Loffler syndrome, Loffler's disease, Loffler's syndrome, Löffler's disease, Löffler's pneumonia.

References

[1] https://en.wikipedia.org/wiki/Löffler's_syndrome

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