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5-Methoxy-6-methyl-2-aminoindane (MMAI), is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. [1]

14 relations: Antidepressant, Binding selectivity, David E. Nichols, Depression (mood), Designer drug, Drug, Empathogen–entactogen, Neurotoxicity, Purdue University, Research chemical, Selective serotonin reuptake inhibitor, Serotonin releasing agent, Sertraline, 4-Methylthioamphetamine.


Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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David E. Nichols

David Earl Nichols (born December 23, 1944, Covington, Kentucky) is an American pharmacologist and medicinal chemist.

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Depression (mood)

Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.

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Designer drug

A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests.

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A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.

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Empathogens or entactogens are a class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy—as particularly observed and reported for experiences with 3,4- Methylenedioxymethamphetamine (MDMA).

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Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system.

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Purdue University

Purdue University is a public research university in West Lafayette, Indiana and is the flagship campus of the Purdue University system.

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Research chemical

Research chemicals are chemical substances used by scientists for medical and scientific research purposes.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Serotonin releasing agent

A serotonin releasing agent (SRA) is a type of drug that induces the release of serotonin into the neuronal synaptic cleft.

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Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

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4-Methylthioamphetamine (4-MTA) is a designer drug developed in the 1990s by a team led by David E. Nichols, an American pharmacologist and medical chemist, at Purdue University.

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Redirects here:

5-Methoxy-6-methyl-2-aminoindane, 5-Methoxy-6-methylaminoindane, 5-Methyl-6-methoxy-2-aminoindane, 5-methoxy-6-methyl-2-aminoindane, 6-Methoxy-5-methyl-2-aminoindane, Methoxymethylaminoindane.


[1] https://en.wikipedia.org/wiki/MMAI

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