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20 relations: Acute lymphoblastic leukemia, Adenine, BRCA1, C-terminus, Carcinogen, Colorectal cancer, Dihydrofolate reductase, DNA mismatch repair, Gene knockdown, HeLa, HL60, K562 cells, Methotrexate, Microsatellite, MSH2, MSH6, MutS-1, Proliferating cell nuclear antigen, Protein dimer, Tumor suppressor.
Acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.
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Adenine
Adenine (A, Ade) is a nucleobase (a purine derivative).
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BRCA1
BRCA1 and BRCA1 are a human gene and its protein product, respectively.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Carcinogen
A carcinogen is any substance, radionuclide, or radiation that promotes carcinogenesis, the formation of cancer.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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Dihydrofolate reductase
Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry.
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DNA mismatch repair
DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.
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Gene knockdown
Gene knockdown is an experimental technique by which the expression of one or more of an organism's genes are reduced.
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HeLa
HeLa (also Hela or hela) is a cell type in an immortal cell line used in scientific research.
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HL60
The HL-60 cell line is a human leukemia cell line that has been used for laboratory research on blood cell formation and physiology.
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K562 cells
K562 cells were the first human immortalised myelogenous leukemia cell line to be established.
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Methotrexate
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.
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Microsatellite
A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 1–6 or more base pairs) are repeated, typically 5–50 times.
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MSH2
DNA mismatch repair protein Msh2 also known as MutS protein homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.
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MSH6
MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae.
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MutS-1
Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome.
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Proliferating cell nuclear antigen
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication.
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Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
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Tumor suppressor
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.
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