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Malonic ester synthesis

Index Malonic ester synthesis

The malonic ester synthesis is a chemical reaction where diethyl malonate or another ester of malonic acid is alkylated at the carbon alpha (directly adjacent) to both carbonyl groups, and then converted to a substituted acetic acid. [1]

20 relations: Acetic acid, Acetoacetic ester synthesis, Alicyclic compound, Alkylation, Alpha and beta carbon, Carbonyl group, Chemical reaction, Chemische Berichte, Decarboxylation, Deprotonation, Diethyl malonate, Ester, Halide, Knoevenagel condensation, Malonic acid, Nucleophilic substitution, Sodium ethoxide, Synthon, Transesterification, William Henry Perkin Jr..

Acetic acid

Acetic acid, systematically named ethanoic acid, is a colourless liquid organic compound with the chemical formula CH3COOH (also written as CH3CO2H or C2H4O2).

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Acetoacetic ester synthesis

Acetoacetic ester synthesis is a chemical reaction where ethyl acetoacetate is alkylated at the α-carbon to both carbonyl groups and then converted into a ketone, or more specifically an α-substituted acetone.

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Alicyclic compound

An alicyclic compound is an organic compound that is both aliphatic and cyclic.

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Alkylation

Alkylation is the transfer of an alkyl group from one molecule to another.

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Alpha and beta carbon

The alpha carbon (Cα) in organic molecules refers to the first carbon atom that attaches to a functional group, such as a carbonyl.

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Carbonyl group

In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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Chemische Berichte

Chemische Berichte (usually abbreviated as Ber. or Chem. Ber.) was a German-language scientific journal of all disciplines of chemistry founded in 1868.

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Decarboxylation

Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2).

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Deprotonation

Deprotonation is the removal (transfer) of a proton (a hydrogen cation, H+) from a Brønsted–Lowry acid in an acid-base reaction.

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Diethyl malonate

Diethyl malonate, also known as DEM, is the diethyl ester of malonic acid.

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Ester

In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.

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Halide

A halide is a binary phase, of which one part is a halogen atom and the other part is an element or radical that is less electronegative (or more electropositive) than the halogen, to make a fluoride, chloride, bromide, iodide, astatide, or theoretically tennesside compound.

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Knoevenagel condensation

The Knoevenagel condensation reaction is an organic reaction named after Emil Knoevenagel.

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Malonic acid

Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2.

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Nucleophilic substitution

In organic and inorganic chemistry, nucleophilic substitution is a fundamental class of reactions in which an electron rich nucleophile selectively bonds with or attacks the positive or partially positive charge of an atom or a group of atoms to replace a leaving group; the positive or partially positive atom is referred to as an electrophile.

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Sodium ethoxide

Sodium ethoxide (also is the organic compound with the formula C2H5ONa) is a white to yellowish powder that dissolves in polar solvents such as ethanol.

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Synthon

In retrosynthetic analysis, a synthon is a destructural unit within a molecule which is related to a possible synthetic operation.

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Transesterification

In organic chemistry, transesterfication is the process of exchanging the organic group R″ of an ester with the organic group R′ of an alcohol.

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William Henry Perkin Jr.

William Henry Perkin Jr., FRS HFRSE (17 June 1860 – 17 September 1929) was an English organic chemist who was primarily known for his groundbreaking research work on the degradation of naturally occurring organic compounds.

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Redirects here:

Malonate ester synthesis, Perkin alicyclic synthesis.

References

[1] https://en.wikipedia.org/wiki/Malonic_ester_synthesis

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