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100 relations: Acid-sensing ion channel, Acidosis, Action potential, Adenosine, Adenosine triphosphate, All-or-none law, AMPA, Apoptosis, Approved drug, Aspartic acid, Axon, Basal ganglia, Blood–brain barrier, Brain, Brain ischemia, Brainstem, Cell membrane, Central nervous system, Cerebellum, Cerebral hypoxia, Channel blocker, Chemical synapse, Clinical trial, Crucian carp, Cytochrome, Cytotoxicity, Depolarization, Depression (physiology), DNA, Electrochemical gradient, Endocytosis, Enzyme, Ethanol, Excitatory postsynaptic potential, Excitotoxicity, Exocytosis, Extracellular, Gamma-Aminobutyric acid, Gap junction, Genetic engineering, Gill, Glutamate receptor, Glutamic acid, Glycolysis, Heat shock protein, Hippocampus, Hyperpnea, Hyperpolarization (biology), Hypoxia (medical), Immediate early gene, ..., Infarction, Inhibitory postsynaptic potential, Insult (medical), Intracellular, Ischemia, Lactic acid, Ligand, Ligand-gated ion channel, Lipolysis, Metabolism, Microtubule, Mitochondrion, N-Methyl-D-aspartic acid, Na+/K+-ATPase, Necrosis, Neocortex, Nerve, Neuroglia, Neuron, Neuroprotection, Neurotransmission, Neurotransmitter, Neurotransmitter transporter, Nitric oxide, NMDA receptor antagonist, P2RX7, Painted turtle, Pannexin, Pasteur effect, Penumbra (medicine), Potassium channel, Proteolysis, Purinergic receptor, Purkinje cell, Pyramidal cell, Radical (chemistry), Receptor (biochemistry), Resting potential, Sigma-1 receptor, Signal transduction, Sodium channel, Stroke, Synapse, Synaptic vesicle, Thalamic reticular nucleus, Thalamus, Threshold potential, Tissue plasminogen activator, Transient ischemic attack, Transient receptor potential channel. Expand index (50 more) »
Acid-sensing ion channel
Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive sodium channels activated by extracellular protons permeable to Na+, however ASIC1 also shows low Ca2+ permeability.
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Acidosis
Acidosis is a process causing increased acidity in the blood and other body tissues (i.e., an increased hydrogen ion concentration).
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Action potential
In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.
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Adenosine
Adenosine is both a chemical found in many living systems and a medication.
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Adenosine triphosphate
Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.
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All-or-none law
The all-or-none law is the principle that the strength by which a nerve or muscle fibre responds to a stimulus is independent of the strength of the stimulus.
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AMPA
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Approved drug
An approved drug is a preparation that has been validated for a therapeutic use by a ruling authority of a government.
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Aspartic acid
Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.
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Axon
An axon (from Greek ἄξων áxōn, axis) or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that typically conducts electrical impulses known as action potentials, away from the nerve cell body.
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Basal ganglia
The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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Brain ischemia
Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is insufficient blood flow to the brain to meet metabolic demand.
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Brainstem
The brainstem (or brain stem) is the posterior part of the brain, adjoining and structurally continuous with the spinal cord.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Cerebellum
The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates.
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Cerebral hypoxia
Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when the brain is completely deprived of oxygen, it is called cerebral anoxia.
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Channel blocker
A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell.
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Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Crucian carp
The crucian carp (Carassius carassius) is a medium-sized member of the common carp family Cyprinidae.
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Cytochrome
Cytochromes are heme-containing proteins.
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Cytotoxicity
Cytotoxicity is the quality of being toxic to cells.
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Depolarization
In biology, depolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell.
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Depression (physiology)
Depression in physiology and medicine refers to a lowering, in particular a reduction in a specific biological variable or the function of an organ.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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Electrochemical gradient
An electrochemical gradient is a gradient of electrochemical potential, usually for an ion that can move across a membrane.
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Endocytosis
Endocytosis is a form of bulk transport in which a cell transports molecules (such as proteins) into the cell (endo- + cytosis) by engulfing them in an energy-using process.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Ethanol
Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.
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Excitatory postsynaptic potential
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.
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Excitotoxicity
Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.
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Exocytosis
Exocytosis is a form of active transport in which a cell transports molecules (e.g., neurotransmitters and proteins) out of the cell (exo- + cytosis) by expelling them through an energy-dependent process.
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Extracellular
In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".
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Gamma-Aminobutyric acid
gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.
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Gap junction
A gap junction may also be called a nexus or macula communicans.
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Genetic engineering
Genetic engineering, also called genetic modification or genetic manipulation, is the direct manipulation of an organism's genes using biotechnology.
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Gill
A gill is a respiratory organ found in many aquatic organisms that extracts dissolved oxygen from water and excretes carbon dioxide.
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Glutamate receptor
Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Glycolysis
Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+.
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Heat shock protein
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions.
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Hippocampus
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
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Hyperpnea
Hyperpnea or hyperpnoea is increased depth and rate of breathing.
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Hyperpolarization (biology)
Hyperpolarization is a change in a cell's membrane potential that makes it more negative.
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Hypoxia (medical)
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.
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Immediate early gene
Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli.
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Infarction
Infarction is tissue death (necrosis) due to inadequate blood supply to the affected area.
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Inhibitory postsynaptic potential
An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential.
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Insult (medical)
In medical terms, an insult is the cause of some kind of physical or mental injury.
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Intracellular
In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".
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Ischemia
Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).
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Lactic acid
Lactic acid is an organic compound with the formula CH3CH(OH)COOH.
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Ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
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Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
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Lipolysis
Lipolysis is the breakdown of lipids and involves hydrolysis of triglycerides into glycerol and free fatty acids.
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Microtubule
Microtubules are tubular polymers of tubulin that form part of the cytoskeleton that provides the cytoplasm of eukaryotic cells and some bacteria with structure and shape.
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Mitochondrion
The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.
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N-Methyl-D-aspartic acid
N-Methyl-D-aspartic acid or N-Methyl-D-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
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Na+/K+-ATPase
-ATPase (sodium-potassium adenosine triphosphatase, also known as the pump or sodium–potassium pump) is an enzyme (an electrogenic transmembrane ATPase) found in the plasma membrane of all animal cells.
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Necrosis
Necrosis (from the Greek νέκρωσις "death, the stage of dying, the act of killing" from νεκρός "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.
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Neocortex
The neocortex, also called the neopallium and isocortex, is the part of the mammalian brain involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language.
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Nerve
A nerve is an enclosed, cable-like bundle of axons (nerve fibers, the long and slender projections of neurons) in the peripheral nervous system.
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Neuroglia
Neuroglia, also called glial cells or simply glia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neuroprotection
Neuroprotection refers to the relative preservation of neuronal structure and/or function.
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Neurotransmission
Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Neurotransmitter transporter
Neurotransmitter transporters are a class of membrane transport proteins that span the cellular membranes of neurons.
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Nitric oxide
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.
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NMDA receptor antagonist
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor (NMDAR).
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P2RX7
P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.
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Painted turtle
The painted turtle (Chrysemys picta) is the most widespread native turtle of North America.
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Pannexin
Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins.
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Pasteur effect
The Pasteur effect is an inhibiting effect of oxygen on the fermentation process.
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Penumbra (medicine)
In pathology and anatomy the penumbra is the area surrounding an ischemic event such as thrombotic or embolic stroke.
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Potassium channel
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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Purinergic receptor
Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules that are found in almost all mammalian tissues.
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Purkinje cell
Purkinje cells, or Purkinje neurons, are a class of GABAergic neurons located in the cerebellum.
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Pyramidal cell
Pyramidal cells, or (pyramidal neurons), are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala.
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Radical (chemistry)
In chemistry, a radical (more precisely, a free radical) is an atom, molecule, or ion that has an unpaired valence electron.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Resting potential
The relatively static membrane potential of quiescent cells is called the resting membrane potential (or resting voltage), as opposed to the specific dynamic electrochemical phenomena called action potential and graded membrane potential.
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Sigma-1 receptor
The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Sodium channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
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Stroke
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
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Synapse
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target efferent cell.
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Synaptic vesicle
In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse.
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Thalamic reticular nucleus
The thalamic reticular nucleus is part of the ventral thalamus that forms a capsule around the thalamus laterally.
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Thalamus
The thalamus (from Greek θάλαμος, "chamber") is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex, and the regulation of consciousness, sleep, and alertness.
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Threshold potential
In neuroscience, the threshold potential is the critical level to which a membrane potential must be depolarized to initiate an action potential.
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Tissue plasminogen activator
Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots.
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Transient ischemic attack
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by loss of blood flow (ischemia) in the brain, spinal cord, or retina, without tissue death (infarction).
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Transient receptor potential channel
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types.
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Stroke: anoxic depolarization and downstream neuronal damage.
References
[1] https://en.wikipedia.org/wiki/Mechanism_of_anoxic_depolarization_in_the_brain
