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Mef2

Index Mef2

In the field of molecular biology, myocyte enhancer factor-2 (Mef2) proteins are a family of transcription factors which through control of gene expression are important regulators of cellular differentiation and consequently play a critical role in embryonic development. [1]

31 relations: Basic helix-loop-helix, C-terminus, Cellular differentiation, Craniofacial, Creatine kinase, Developmental biology, DLX5, DLX6, DNA-binding domain, Enhancer (genetics), Eukaryote, Gene, Gene expression, Homeobox, MADS-box, MEF2B, MEF2C, MEF2D, Molecular biology, Myocyte-specific enhancer factor 2A, N-terminus, Neural crest, Nuclear localization sequence, Promoter (genetics), Protein, Stress (biology), Transcription factor, Ventricular hypertrophy, Vertebrate, X-ray crystallography, Yeast.

Basic helix-loop-helix

A basic helix-loop-helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors.

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Craniofacial

Craniofacial (cranio- combining form meaning head or skull + -facial combining form referring to the facial structures grossly) is an adjective referring to the parts of the head enclosing the brain and the face.

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Creatine kinase

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types.

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Developmental biology

Developmental biology is the study of the process by which animals and plants grow and develop.

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DLX5

Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene.

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DLX6

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.

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DNA-binding domain

A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.

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Enhancer (genetics)

In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur.

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Eukaryote

Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.

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Homeobox

A homeobox is a DNA sequence, around 180 base pairs long, found within genes that are involved in the regulation of patterns of anatomical development (morphogenesis) in animals, fungi and plants.

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MADS-box

The MADS box is a conserved sequence motif.

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MEF2B

Myocyte enhancer binding factor 2B (MEF2B) is a transcription factor part of the MEF2 gene family including MEF2A, MEF2C, and MEF2D.

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MEF2C

Myocyte-specific enhancer factor 2C also known as MADS box transcription enhancer factor 2, polypeptide C is a protein that in humans is encoded by the MEF2C gene.

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MEF2D

Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.

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Molecular biology

Molecular biology is a branch of biology which concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions.

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Myocyte-specific enhancer factor 2A

Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene.

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N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Neural crest

Neural crest cells are a temporary group of cells unique to chordates of the group Cristozoa that arise from the embryonic ectoderm cell layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric neurons and glia.

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Nuclear localization sequence

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.

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Promoter (genetics)

In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Stress (biology)

Physiological or biological stress is an organism's response to a stressor such as an environmental condition.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Ventricular hypertrophy

Ventricular hypertrophy (VH) is thickening of the walls of a ventricle (lower chamber) of the heart.

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Vertebrate

Vertebrates comprise all species of animals within the subphylum Vertebrata (chordates with backbones).

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X-ray crystallography

X-ray crystallography is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.

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Yeast

Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom.

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Redirects here:

MEF2, Myocyte Enhancer Factor.

References

[1] https://en.wikipedia.org/wiki/Mef2

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