27 relations: Active metabolite, Allosteric modulator, Anabolic steroid, Androgen, Androgen receptor, Antigonadotropin, Breast cancer, Cell signaling, Cell surface receptor, Dihydrotestosterone, Estrous cycle, G protein–coupled receptor, GABAA receptor, Genome, GPRC6A, Human sexual activity, Intracellular, Membrane steroid receptor, Neurosteroid, Nuclear receptor, Prostate cancer, Signal transduction, Skeletal muscle, Testicle, Testosterone, ZIP9, 3α-Androstanediol.
An active metabolite is an active form of a drug after it has been processed by the body.
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.
Anabolic steroids, also known more properly as anabolic–androgenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects to testosterone.
An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Breast cancer is cancer that develops from breast tissue.
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.
Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.
The estrous cycle or oestrus cycle (derived from Latin oestrus 'frenzy', originally from Greek οἶστρος oîstros 'gadfly') is the recurring physiological changes that are induced by reproductive hormones in most mammalian therian females.
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
In the fields of molecular biology and genetics, a genome is the genetic material of an organism.
G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene.
Human sexual activity, human sexual practice or human sexual behaviour is the manner in which humans experience and express their sexuality.
In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".
Membrane steroid receptors (mSRs), also called extranuclear steroid receptors, are a class of cell surface receptors activated by endogenous steroids that mediate rapid, non-genomic signaling via modulation of intracellular signaling cascades.
Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle.
The testicle or testis is the male reproductive gland in all animals, including humans.
Testosterone is the primary male sex hormone and an anabolic steroid.
Zinc transporter ZIP9 also known as Zrt- and Irt-like protein 9 (ZIP9) and solute carrier family 39 member 9 (SLC39A9) is a protein that in humans is encoded by the SLC39A9 gene.
3α-Androstanediol (often abbreviated as 3α-diol), also known as 5α-androstane-3α,17β-diol, is an endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT).