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Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. [1]

122 relations: Acetylation, Aldous Huxley, Alexander Shulgin, Alkaloid, Amide reduction, Antioxidant, Aromatic L-amino acid decarboxylase, Arthur Heffter, BBC, Biosynthesis, Bryan Wynter, Cactus, Carboxylic acid, Carlos Santana, Catechol-O-methyltransferase, Catecholamine, Christopher Mayhew, Controlled Drugs and Substances Act, Controlled Substances Act, Convention on Psychotropic Substances, Cortisol, Crystal Fairy & the Magical Cactus, Cubism, Cyanohydrin reaction, CYP2D6, Dopamine, Drug tolerance, Echinopsis, Echinopsis pachanoi, Echinopsis peruviana, Elemicin, Entheogen, Ernst Späth, Erowid, Ester, Eudesmic acid, Fabaceae, Fear and Loathing in Las Vegas, Flow My Tears, the Policeman Said, Fractal, George Carlin, Hallucinogen, Halogenation, Havelock Ellis, Hofmann rearrangement, Huichol, Humphry Osmond, Hunter S. Thompson, Indigenous peoples of the Americas, International Narcotics Control Board, ..., James Taylor, Jean-Paul Sartre, Jim Carroll, Kaleidoscope, Kolbe nitrile synthesis, L-DOPA, Ligand (biochemistry), List of psychoactive plants, Lysergic acid diethylamide, Martin Kemp, Median lethal dose, Methyl group, Methylation, Michael Cera, Mind at Large, Monoamine oxidase, Native American Church, Natural product, Nausea (novel), Neuron, Neurotransmitter, Nitrile reduction, Nitroaldol reaction, Nitromethane, Northern Territory, One Man Dog, Organic redox reaction, Ornamental plant, Ozonolysis, Panorama (TV series), Paul Strathern, Peripheral nervous system, Peyote, Phenylalanine, Philip K. Dick, Potassium cyanide, Prefrontal cortex, Psilocybin, Psychedelic drug, Psychedelic experience, Psychoactive drug, Queensland, Reduction of nitro compounds, Reductive amination, Religious Freedom Restoration Act, Rolling Stone, Rubber Soul, S-Adenosyl methionine, Senegalia berlandieri, Serotonergic psychedelic, Serotonin, Songs of the Doomed, Spandau Ballet, Standard for the Uniform Scheduling of Medicines and Poisons, Stanisław Ignacy Witkiewicz, Substituted phenethylamine, Synesthesia, The Basketball Diaries, The Beatles, The Doors of Perception, The Psychedelic Experience, Trimethoxyamphetamine, Tyramine, Tyrosine, Tyrosine decarboxylase, Tyrosine hydroxylase, Utah, Ward Kimball, Western Australia, 3,4,5-Trimethoxybenzaldehyde, 5-HT2A receptor, 5-HT2C receptor. Expand index (72 more) »


Acetylation (or in IUPAC nomenclature ethanoylation) describes a reaction that introduces an acetyl functional group into a chemical compound.

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Aldous Huxley

Aldous Leonard Huxley (26 July 1894 – 22 November 1963) was an English writer, novelist, philosopher, and prominent member of the Huxley family.

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Alexander Shulgin

Alexander Theodore "Sasha" Shulgin (June 17, 1925 June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author.

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Alkaloids are a class of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.

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Amide reduction

Amide reduction is a reaction in organic synthesis where an amide is reduced to either an amine or an aldehyde functional group.

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Antioxidants are molecules that inhibit the oxidation of other molecules.

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Aromatic L-amino acid decarboxylase

Aromatic L-amino acid decarboxylase (AADC or AAAD), also known as DOPA decarboxylase (DDC), tryptophan decarboxylase, and 5-hydroxytryptophan decarboxylase, is a lyase enzyme.

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Arthur Heffter

Arthur Carl Wilhelm Heffter (15 June 1859, in Leipzig – 8 February 1925, in Berlin) was a German pharmacologist and chemist.

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The British Broadcasting Corporation (BBC) is a British public service broadcaster.

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Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.

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Bryan Wynter

Bryan Herbert Wynter (8 September 1915 – 2 February 1975) was one of the St. Ives group of British painters.

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A cactus (plural: cacti, cactuses, or cactus) is a member of the plant family Cactaceae,Although the spellings of botanical families have been largely standardized, there is little agreement among botanists as to how these names are to be pronounced.

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Carboxylic acid

A carboxylic acid is an organic compound that contains a carboxyl group (C(.

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Carlos Santana

Carlos Santana (born July 20, 1947) is a Mexican and American musician who first became famous in the late 1960s and early 1970s with his band, Santana, which pioneered a fusion of rock and Latin American jazz.

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Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure.

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A catecholamine (CA) is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine.

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Christopher Mayhew

Christopher Paget Mayhew, Baron Mayhew (12 June 1915 – 7 January 1997) was a British politician who was a Labour Member of Parliament (MP) from 1945 to 1950 and from 1951 to 1974, when he left the Labour Party to join the Liberals.

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Controlled Drugs and Substances Act

The Controlled Drugs and Substances Act (Loi réglementant certaines drogues et autres substances) (the Act) is Canada's federal drug control statute.

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Controlled Substances Act

The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

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Convention on Psychotropic Substances

The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 1971.

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Cortisol is a steroid hormone, in the glucocorticoid class of hormones.

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Crystal Fairy & the Magical Cactus

Crystal Fairy & The Magical Cactus (Crystal Fairy & The Magical Cactus and 2012 as presented onscreen) is a 2013 Chilean adventure comedy film written and directed by Sebastián Silva.

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Cubism is an early-20th-century art movement which brought European painting and sculpture historically forward toward 20th century Modern art.

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Cyanohydrin reaction

A cyanohydrin reaction is an organic chemical reaction by an aldehyde or ketone with a cyanide anion or a nitrile to form a cyanohydrin.

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Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.

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Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Drug tolerance

Drug tolerance is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.

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Echinopsis is a large genus of cacti native to South America, sometimes known as hedgehog cactus, sea-urchin cactus or Easter lily cactus.

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Echinopsis pachanoi

Echinopsis pachanoi (syn. Trichocereus pachanoi) — known as San Pedro cactus — is a fast-growing columnar cactus native to the Andes Mountains at in altitude.

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Echinopsis peruviana

Echinopsis peruviana (syn. Trichocereus peruvianus), the Peruvian torch cactus, is a fast-growing columnar cactus native to the western slope of the Andes in Peru, between about above sea level.

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Elemicin is a phenylpropene, a natural organic compound, and is a constituent of several plant species' essential oils.

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An entheogen is a class of psychoactive substances that induce any type of spiritual experience aimed at development.

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Ernst Späth

Ernst Späth (14 May 1886, in Moravský Beroun (Bärn), northern Moravia – 30 September 1946, in Zurich) was an Austrian chemist, specializing in natural products.

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Erowid, also called Erowid Center, is a 501(c)(3) non-profit educational organization that provides information about psychoactive plants and chemicals as well as activities and technologies that can produce altered states of consciousness such as meditation, lucid dreaming, transcranial magnetic stimulation, and electroceuticals.

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In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.

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Eudesmic acid

Eudesmic acid is an O-methylated trihydroxybenzoic acid.

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The Fabaceae or Leguminosae, Article 18.5 states: "The following names, of long usage, are treated as validly published:....Leguminosae (nom. alt.: Fabaceae; type: Faba Mill.);...

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Fear and Loathing in Las Vegas

Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream is a novel by Hunter S. Thompson, illustrated by Ralph Steadman.

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Flow My Tears, the Policeman Said

Flow My Tears, the Policeman Said is a 1974 science fiction novel by American writer Philip K. Dick.

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In mathematics, a fractal is an abstract object used to describe and simulate naturally occurring objects.

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George Carlin

George Denis Patrick Carlin (May 12, 1937 – June 22, 2008) was an American stand-up comedian, actor, author, and social critic.

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A hallucinogen is a psychoactive agent which can cause hallucinations, perceptual anomalies, and other substantial subjective changes in thoughts, emotion, and consciousness.

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Halogenation is a chemical reaction that involves the addition of one or more halogens to a compound or material.

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Havelock Ellis

Henry Havelock Ellis, known as Havelock Ellis (2 February 1859 – 8 July 1939), was an English physician, writer, progressive intellectual and social reformer who studied human sexuality.

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Hofmann rearrangement

The Hofmann rearrangement is the organic reaction of a primary amide to a primary amine with one fewer carbon atom.

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The Huichol or Wixáritari (Huichol pronunciation: /wiˈraɾitaɾi/) are an indigenous people of Mexico living in the Sierra Madre Occidental range in the states of Nayarit, Jalisco, Zacatecas, and Durango. They are best known to the larger world as the Huichol, however, they refer to themselves as Wixáritari ("the people") in their native Huichol language. The adjectival form of Wixáritari and name for their own language is Wixárika.

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Humphry Osmond

Humphry Fortescue Osmond (1 July 1917 – 6 February 2004) was an English psychiatrist who expatriated to Canada, then moved to work in the United States.

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Hunter S. Thompson

Hunter Stockton Thompson (July 18, 1937 – February 20, 2005) was an American journalist and author, and the founder of the gonzo journalism movement.

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Indigenous peoples of the Americas

The indigenous peoples of the Americas are the pre-Columbian peoples of the Americas and their descendants. Although some indigenous peoples of the Americas were traditionally hunter-gatherers—and many, especially in the Amazon basin, still are—many groups practiced aquaculture and agriculture. The impact of their agricultural endowment to the world is a testament to their time and work in reshaping and cultivating the flora indigenous to the Americas. Although some societies depended heavily on agriculture, others practiced a mix of farming, hunting and gathering. In some regions the indigenous peoples created monumental architecture, large-scale organized cities, chiefdoms, states and empires. Many parts of the Americas are still populated by indigenous peoples; some countries have sizable populations, especially Belize, Bolivia, Canada, Chile, Ecuador, Greenland, Guatemala, Guyana, Mexico, Panama and Peru. At least a thousand different indigenous languages are spoken in the Americas. Some, such as the Quechuan languages, Aymara, Guaraní, Mayan languages and Nahuatl, count their speakers in millions. Many also maintain aspects of indigenous cultural practices to varying degrees, including religion, social organization and subsistence practices. Like most cultures, over time, cultures specific to many indigenous peoples have evolved to incorporate traditional aspects but also cater to modern needs. Some indigenous peoples still live in relative isolation from Western culture, and a few are still counted as uncontacted peoples.

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International Narcotics Control Board

The International Narcotics Control Board (INCB) is the independent and quasi-judicial control organ for the implementation of the United Nations drug conventions.

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James Taylor

James Vernon Taylor (born March 12, 1948) is an American singer-songwriter and guitarist.

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Jean-Paul Sartre

Jean-Paul Charles Aymard Sartre (21 June 1905 – 15 April 1980) was a French philosopher, playwright, novelist, political activist, biographer, and literary critic.

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Jim Carroll

James Dennis Carroll (August 1, 1949 – September 11, 2009) was an American author, poet, autobiographer, and punk musician.

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A kaleidoscope is an optical instrument with two or more reflecting surfaces tilted to each other in an angle, so that one or more (parts of) objects on one end of the mirrors are seen as a regular symmetrical pattern when viewed from the other end, due to repeated reflection.

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Kolbe nitrile synthesis

The Kolbe nitrile synthesis is a method for the preparation of alkyl nitriles by reaction of the corresponding alkyl halide with a metal cyanide.

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L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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List of psychoactive plants

A list of plants that are used as psychoactive drugs.

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Lysergic acid diethylamide

Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not.

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Martin Kemp

Martin John Kemp (born 10 October 1961) is an English actor, director, musician, occasional television presenter, best known as the bassist in the new wave band Spandau Ballet and for his portrayal as Steve Owen from the BBC soap opera EastEnders.

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Median lethal dose

In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a measure of the lethal dose of a toxin, radiation, or pathogen.

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Methyl group

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.

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In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.

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Michael Cera

Michael Austin Cera (born June 7, 1988) is a Canadian actor and musician.

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Mind at Large

Mind at Large is a concept from The Doors of Perception and Heaven and Hell by Aldous Huxley.

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Monoamine oxidase

L-Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines.

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Native American Church

The Native American Church (NAC), also known as Peyotism and Peyote Religion, is a Native American religion that teaches a combination of traditional Native American beliefs and Christianity, with sacramental use of the entheogen peyote.

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Natural product

A natural product is a chemical compound or substance produced by a living organism—that is, found in nature.

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Nausea (novel)

Nausea (La Nausée) is a philosophical novel by the existentialist philosopher Jean-Paul Sartre, published in 1938.

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A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

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Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Nitrile reduction

In nitrile reduction a nitrile is reduced to either an amine or an aldehyde with a suitable chemical reagent.

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Nitroaldol reaction

The Henry Reaction (also referred to as the nitro-aldol reaction) is a classic carbon–carbon bond formation reaction in organic chemistry.

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Nitromethane is an organic compound with the chemical formula.

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Northern Territory

The Northern Territory (abbreviated as NT) is a federal Australian territory in the central and central northern regions of Australia.

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One Man Dog

One Man Dog is the fourth studio album by singer-songwriter James Taylor.

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Organic redox reaction

Organic reductions or organic oxidations or organic redox reactions are redox reactions that take place with organic compounds.

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Ornamental plant

Ornamental plants are plants that are grown for decorative purposes in gardens and landscape design projects, as houseplants, for cut flowers and specimen display.

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Ozonolysis is an organic reaction where the unsaturated bonds of alkenes, alkynes, or azo compounds are cleaved with ozone.

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Panorama (TV series)

Panorama is a BBC Television investigative current affairs documentary programme.

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Paul Strathern

Paul Strathern (born 1940) is a British writer and academic.

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Peripheral nervous system

The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).

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Lophophora williamsii or peyote is a small, spineless cactus with psychoactive alkaloids, particularly mescaline.

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Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.

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Philip K. Dick

Philip Kindred Dick (December 16, 1928 – March 2, 1982) was an American writer known for his work in science fiction.

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Potassium cyanide

Potassium cyanide is a compound with the formula KCN.

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Prefrontal cortex

In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.

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Psilocybin is a naturally occurring psychedelic prodrug compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms.

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Psychedelic drug

Psychedelics are a class of drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing thought and visual/auditory changes, and altered state of consciousness.

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Psychedelic experience

A psychedelic experience (or 'trip') is a temporary altered state of consciousness induced by the consumption of psychedelic drugs (such as mescaline, LSD, psilocybin, and DMT).

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Psychoactive drug

A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior.

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Queensland (abbreviated as Qld) is the second-largest and third-most populous state in the Commonwealth of Australia.

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Reduction of nitro compounds

The chemical reactions described as reduction of nitro compounds can be affected by many reagents and reaction conditions.

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Reductive amination

Reductive amination (also known as reductive alkylation) is a form of amination that involves the conversion of a carbonyl group to an amine via an intermediate imine.

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Religious Freedom Restoration Act

The Religious Freedom Restoration Act of 1993, Pub.

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Rolling Stone

Rolling Stone is an American monthly magazine that focuses on popular culture.

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Rubber Soul

Rubber Soul is the sixth album by the English rock band the Beatles.

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S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.

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Senegalia berlandieri

Senegalia berlandieri (Berlandier Acacia, Guajillo Acacia, guajillo, huajillo) is a shrub native to the Southwestern United States and northeast Mexico that belongs to the subfamily Mimosoideae (wattles) of Fabaceae (legumes).

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Serotonergic psychedelic

Serotonergic psychedelics (also known as serotonergic hallucinogens) are a subclass of psychedelic drugs with a method of action strongly tied to the neurotransmitter serotonin.

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Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Songs of the Doomed

Gonzo Papers, Vol.

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Spandau Ballet

Spandau Ballet are an English band formed in Islington, London in 1979.

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Standard for the Uniform Scheduling of Medicines and Poisons

The Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP) is an Australian legislative instrument produced by the Therapeutic Goods Administration (TGA).

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Stanisław Ignacy Witkiewicz

Stanisław Ignacy Witkiewicz (24 February 188518 September 1939), commonly known as Witkacy, was a Polish writer, painter, philosopher, playwright, novelist, and photographer active in the interwar period.

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Substituted phenethylamine

Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents.

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Synesthesia is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway.

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The Basketball Diaries

The Basketball Diaries is a 1978 memoir written by author and musician Jim Carroll.

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The Beatles

The Beatles were an English rock band formed in Liverpool in 1960.

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The Doors of Perception

The Doors of Perception is a philosophical essay, released as a book, by Aldous Huxley.

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The Psychedelic Experience

The Psychedelic Experience: A Manual Based on The Tibetan Book of the Dead (commonly referred to as The Psychedelic Experience) is a book about using psychedelic drugs that was coauthored by Timothy Leary, Ralph Metzner and Richard Alpert, all of whom had previously taken part in research investigating the therapeutic potential of psychedelic drugs such as LSD, psilocybin and mescaline in addition to the ability of these substances to sometimes induce religious and mystical states of consciousness.

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TMAs, also known as trimethoxyamphetamines, are a family of isomeric psychedelic hallucinogenic drugs.

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Tyramine (also spelled tyramin), also known by several other names is a naturally occurring trace amine derived from the amino acid tyrosine.

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Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.

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Tyrosine decarboxylase

In enzymology, a tyrosine decarboxylase is an enzyme that catalyzes the chemical reaction Hence, this enzyme has one substrate, L-tyrosine, and two products, tyramine and carbon dioxide.

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Tyrosine hydroxylase

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA).

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Utah is a state in the western United States.

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Ward Kimball

Ward Walrath Kimball (March 4, 1914 – July 8, 2002), born in Minneapolis, Minnesota, was an animator for the Walt Disney Studios.

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Western Australia

Western Australia (abbreviated as WA) is a state occupying the entire western third of Australia.

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3,4,5-Trimethoxybenzaldehyde is an organic compound.

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5-HT2A receptor

The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).

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5-HT2C receptor

The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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2-(3,4,5-trimethoxyphenyl)ethanamine, 3,4,5-Trimethoxy-phenethylamine, 3,4,5-trimethoxyphenethylamine, Legal status of mescaline, Legality of mescaline, Mescalene, Mescalin, Synthemesc, Synthmesc.


[1] https://en.wikipedia.org/wiki/Mescaline

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