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Metalation

Index Metalation

Metalation (Alt. Spelling: Metallation) is a chemical reaction which involves the bonding of a metal atom to what is typically an organic molecule to form a new compound. [1]

38 relations: Acid–base reaction, Aldehyde, Base (chemistry), Carbon–hydrogen bond activation, Chemical polarity, Chemical reaction, Deprotonation, Edward Frankland, Electron density, Electron transfer, Electronegativity, Electrophile, Functional group, Georg Wittig, Grignard reaction, Halide, Haloalkane, Henry Gilman, Ionic bonding, Karl Ziegler, Ketone, Magnesium, Methyllithium, N-Butyllithium, Nucleophile, Nucleophilic substitution, Organic compound, Organolithium reagent, Organometallic chemistry, Organozinc compound, Polymerization, Protecting group, Pyrophoricity, Redox, Steric effects, Superbase, Transmetalation, Victor Grignard.

Acid–base reaction

An acid–base reaction is a chemical reaction that occurs between an acid and a base, which can be used to determine pH.

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Aldehyde

An aldehyde or alkanal is an organic compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group, which is any generic alkyl or side chain.

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Base (chemistry)

In chemistry, bases are substances that, in aqueous solution, release hydroxide (OH−) ions, are slippery to the touch, can taste bitter if an alkali, change the color of indicators (e.g., turn red litmus paper blue), react with acids to form salts, promote certain chemical reactions (base catalysis), accept protons from any proton donor, and/or contain completely or partially displaceable OH− ions.

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Carbon–hydrogen bond activation

Carbon–hydrogen bond functionalization (C–H functionalization) is a type of reaction in which a carbon–hydrogen bond is cleaved and replaced with a carbon-X bond (where X is usually carbon, oxygen, or nitrogen).

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Chemical polarity

In chemistry, polarity is a separation of electric charge leading to a molecule or its chemical groups having an electric dipole or multipole moment.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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Deprotonation

Deprotonation is the removal (transfer) of a proton (a hydrogen cation, H+) from a Brønsted–Lowry acid in an acid-base reaction.

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Edward Frankland

Sir Edward Frankland, (18 January 1825 – 9 August 1899) was a British chemist.

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Electron density

Electron density is the measure of the probability of an electron being present at a specific location.

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Electron transfer

Electron transfer (ET) occurs when an electron relocates from an atom or molecule to another such chemical entity.

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Electronegativity

Electronegativity, symbol ''χ'', is a chemical property that describes the tendency of an atom to attract a shared pair of electrons (or electron density) towards itself.

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Electrophile

In organic chemistry, an electrophile is a reagent attracted to electrons.

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Functional group

In organic chemistry, functional groups are specific substituents or moieties within molecules that are responsible for the characteristic chemical reactions of those molecules.

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Georg Wittig

Georg Wittig (June 16, 1897 – August 26, 1987) was a German chemist who reported a method for synthesis of alkenes from aldehydes and ketones using compounds called phosphonium ylides in the Wittig reaction.

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Grignard reaction

The Grignard reaction (pronounced) is an organometallic chemical reaction in which alkyl, vinyl, or aryl-magnesium halides (Grignard reagents) add to a carbonyl group in an aldehyde or ketone.

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Halide

A halide is a binary phase, of which one part is a halogen atom and the other part is an element or radical that is less electronegative (or more electropositive) than the halogen, to make a fluoride, chloride, bromide, iodide, astatide, or theoretically tennesside compound.

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Haloalkane

The haloalkanes (also known as halogenoalkanes or alkyl halides) are a group of chemical compounds derived from alkanes containing one or more halogens.

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Henry Gilman

Henry Gilman (May 9, 1893 – November 7, 1986) was an American organic chemist known as the father of organometallic chemistry, the field within which his most notable work was done.

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Ionic bonding

Ionic bonding is a type of chemical bonding that involves the electrostatic attraction between oppositely charged ions, and is the primary interaction occurring in ionic compounds.

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Karl Ziegler

Karl Waldemar Ziegler (November 26, 1898 – August 12, 1973) was a German chemist who won the Nobel Prize in Chemistry in 1963, with Giulio Natta, for work on polymers.

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Ketone

In chemistry, a ketone (alkanone) is an organic compound with the structure RC(.

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Magnesium

Magnesium is a chemical element with symbol Mg and atomic number 12.

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Methyllithium

Methyllithium is the simplest organolithium reagent with the empirical formula CH3Li.

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N-Butyllithium

n-Butyllithium (abbreviated n-BuLi) is an organolithium reagent.

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Nucleophile

Nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.

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Nucleophilic substitution

In organic and inorganic chemistry, nucleophilic substitution is a fundamental class of reactions in which an electron rich nucleophile selectively bonds with or attacks the positive or partially positive charge of an atom or a group of atoms to replace a leaving group; the positive or partially positive atom is referred to as an electrophile.

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Organic compound

In chemistry, an organic compound is generally any chemical compound that contains carbon.

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Organolithium reagent

Organolithium reagents are organometallic compounds that contain carbon – lithium bonds.

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Organometallic chemistry

Organometallic chemistry is the study of organometallic compounds, chemical compounds containing at least one chemical bond between a carbon atom of an organic molecule and a metal, including alkaline, alkaline earth, and transition metals, and sometimes broadened to include metalloids like boron, silicon, and tin, as well.

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Organozinc compound

Organozinc compounds in organic chemistry contain carbon to zinc chemical bonds.

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Polymerization

In polymer chemistry, polymerization is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks.

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Protecting group

A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction.

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Pyrophoricity

A pyrophoric substance (from Greek πυροφόρος, pyrophoros, "fire-bearing") ignites spontaneously in air at or below 55 °C (130 °F).

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Steric effects

Steric effects are nonbonding interactions that influence the shape (conformation) and reactivity of ions and molecules.

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Superbase

In chemistry, a superbase is an extremely basic compound or caustic substance that has a high affinity for protons.

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Transmetalation

Transmetalation (alt. spelling: transmetallation) is a type of organometallic reaction that involves the transfer of ligands from one metal to another.

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Victor Grignard

François Auguste Victor Grignard (6 May 1871 in Cherbourg – 13 December 1935 in Lyon) was a Nobel Prize-winning French chemist.

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Metalation reaction, Metallation.

References

[1] https://en.wikipedia.org/wiki/Metalation

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