13 relations: Cancer, Chemotherapy, CYP3A4, Demethylation, Enzyme, Glucocorticoid receptor, Ligand (biochemistry), Liver, Metabolite, Metastasis, Mifepristone, Progesterone receptor, Selective progesterone receptor modulator.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
Demethylation is the chemical process resulting in the removal of a methyl group (CH3) from a molecule.
Enzymes are macromolecular biological catalysts.
The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
A metabolite is the intermediate end product of metabolism.
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor.
Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol, to bring about an abortion.
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.
A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor.
C28H33NO2, Demethylmifepristone, Desmethylmifepristone, Monodemethylmifepristone, Monodesmethylmifepristone, N-Demethylmifepristone, N-Desmethylmifepristone, N-demethylmifepristone, N-desmethylmifepristone, R 42,633, R 42633, R-42,633, R-42633, R42633, RU 42,633, RU 42633, RU-42,633, RU-42633, RU42633.