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Monoclonal gammopathy of undetermined significance

Index Monoclonal gammopathy of undetermined significance

Monoclonal gammopathy of undetermined significance (MGUS, unknown or uncertain may be substituted for undetermined), formerly benign monoclonal gammopathy, is a condition in which an abnormal immunoglobin protein (known as a paraprotein) is found in the blood during standard laboratory blood tests. [1]

41 relations: Amyloidosis, Anemia, Antibody, B-cell lymphoma, Bence Jones protein, Blood, Blood test, Bone marrow, Bone marrow examination, CD19, CD38, Chronic kidney disease, Chronic lymphocytic leukemia, Clone (B-cell biology), Connective tissue disease, Expert Review of Hematology, Gel electrophoresis of proteins, Ghana, Guillain–Barré syndrome, Hematology, Hepatitis C, HIV/AIDS, Hypercalcaemia, Immunophenotyping, Multiple myeloma, Myeloma protein, Neural cell adhesion molecule, Non-Hodgkin lymphoma, Olmsted County, Minnesota, Paraproteinemia, Peripheral neuropathy, Physician, Plasma cell, Renal function, Skeletal survey, Splenic marginal zone lymphoma, Systemic lupus erythematosus, TEMPI syndrome, The New England Journal of Medicine, Waldenström's macroglobulinemia, White blood cell.

Amyloidosis

Amyloidosis is a group of diseases in which abnormal protein, known as amyloid fibrils, builds up in tissue.

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Anemia

Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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B-cell lymphoma

The B-cell lymphomas are types of lymphoma affecting B cells.

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Bence Jones protein

A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa.

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Blood

Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.

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Blood test

A blood test is a laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick.

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Bone marrow

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.

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Bone marrow examination

Bone marrow examination refers to the pathologic analysis of samples of bone marrow obtained by bone marrow biopsy (often called a trephine biopsy) and bone marrow aspiration.

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CD19

B-lymphocyte antigen CD19, also known as CD19 molecule ('''C'''luster of '''D'''ifferentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19.

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CD38

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells.

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Chronic kidney disease

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months or years.

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Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).

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Clone (B-cell biology)

The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity.

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Connective tissue disease

A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology.

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Expert Review of Hematology

Expert Review of Hematology is a MEDLINE-indexed, peer-reviewed, international medical journal publishing review articles and original papers on all aspects of hematology.

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Gel electrophoresis of proteins

Protein electrophoresis is a method for analysing the proteins in a fluid or an extract.

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Ghana

Ghana, officially the Republic of Ghana, is a unitary presidential constitutional democracy, located along the Gulf of Guinea and Atlantic Ocean, in the subregion of West Africa.

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Guillain–Barré syndrome

Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system.

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Hematology

Hematology, also spelled haematology, is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood.

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Hepatitis C

Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver.

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HIV/AIDS

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).

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Hypercalcaemia

Hypercalcaemia, also spelled hypercalcemia, is a high calcium (Ca2+) level in the blood serum.

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Immunophenotyping

Immunophenotyping is a technique used to study the protein expressed by cells.

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Multiple myeloma

Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.

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Myeloma protein

A myeloma protein is an abnormal immunoglobulin fragment, such as an immunoglobulin light chain, that is produced in excess by an abnormal monoclonal proliferation of plasma cells, typically in multiple myeloma.

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Neural cell adhesion molecule

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle.

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Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas.

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Olmsted County, Minnesota

Olmsted County is a county in the U.S. state of Minnesota.

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Paraproteinemia

Paraproteinemia, also known as monoclonal gammopathy, is the presence of excessive amounts of paraprotein or single monoclonal gammaglobulin in the blood.

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Peripheral neuropathy

Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected.

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Physician

A physician, medical practitioner, medical doctor, or simply doctor is a professional who practises medicine, which is concerned with promoting, maintaining, or restoring health through the study, diagnosis, and treatment of disease, injury, and other physical and mental impairments.

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Plasma cell

Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies.

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Renal function

Renal function, in nephrology, is an indication of the kidney's condition and its role in renal physiology.

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Skeletal survey

A skeletal survey (also called a bone survey) is a series of X-rays of all the bones in the body, or at least the axial skeleton and the large cortical bones.

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Splenic marginal zone lymphoma

Splenic marginal zone lymphoma (SMZL) is a type of cancer (specifically a lymphoma) made up of B-cells that replace the normal architecture of the white pulp of the spleen.

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Systemic lupus erythematosus

Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.

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TEMPI syndrome

TEMPI Syndrome is a novel orphan disease where the person share five characteristics from which the acronym is derived: telangiectasias, elevated erythropoietin and erythrocytosis, monoclonal gammopathy, perinephric fluid collection, and intrapulmonary shunting.

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The New England Journal of Medicine

The New England Journal of Medicine (NEJM) is a weekly medical journal published by the Massachusetts Medical Society.

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Waldenström's macroglobulinemia

Waldenström's macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of cancer affecting two types of B cells, lymphoplasmacytoid cells and plasma cells.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Redirects here:

Hyperimmunization, MGUS, MUGS disease, Mgus, Monoclonal Gammopathy of Uncertain Significance, Monoclonal gammopathies, benign, Monoclonal gammopathy of uncertain significance, Monoclonal gammopathy of unknown significance.

References

[1] https://en.wikipedia.org/wiki/Monoclonal_gammopathy_of_undetermined_significance

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