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Milnacipran (Ixel, Savella, Dalcipran, Toledomin) is a serotonin–norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. [1]

58 relations: Alcohol, Alpha-1 adrenergic receptor, Angina pectoris, Anticholinergic, Austria, Binding site, Bulgaria, Canada, Clonidine, Delirium, Digitalis, Dopamine receptor D1, Dopamine receptor D2, Epinephrine, Europe, European Medicines Agency, Fibromyalgia, Finland, Food and Drug Administration, France, GABAA receptor, Glycoside, Histamine H1 receptor, Imipramine, Japan, Kidney, Laboratoires Pierre Fabre, Liver, Liver function tests, Major depressive disorder, Mania, Mexico, Moclobemide, Monoamine oxidase inhibitor, Muscarinic acetylcholine receptor, Myocardial infarction, Neurotransmitter, Norepinephrine, Opioid receptor, Phenelzine, Portugal, Psychomotor agitation, Psychosis, Receptor (biochemistry), Reuptake, Reuptake inhibitor, Russia, Sedation, Selegiline, Serotonin, ..., Serotonin–norepinephrine reuptake inhibitor, Sleep, Suicide crisis, Toloxatone, Tranylcypromine, Tricyclic antidepressant, Triptan, United States. Expand index (8 more) »


In chemistry, an alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a saturated carbon atom.

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Alpha-1 adrenergic receptor

The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.

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Angina pectoris

Angina pectoris, commonly known as angina, is the sensation of chest pain, pressure, or squeezing, often due to ischemia of the heart muscle from obstruction or spasm of the coronary arteries.

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An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.

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Austria (Österreich), officially the Republic of Austria (Republik Österreich), is a federal republic and a landlocked country of over 8.5 million people in Central Europe.

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Binding site

In biochemistry, a binding site is a region on a protein or piece of DNA or RNA to which ligands (specific molecules and/or ions) may form a chemical bond.

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Bulgaria (България, tr.), officially the Republic of Bulgaria (Република България, tr.), is a country in southeastern Europe.

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Canada is a country, consisting of ten provinces and three territories, in the northern part of the continent of North America.

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Clonidine (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a sympatholytic medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions.

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Delirium, or acute confusional state, is an organically-caused decline from a previously attained baseline level of cognitive function.

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Digitalis is a genus of about 20 species of herbaceous perennials, shrubs, and biennials commonly called foxgloves.

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Dopamine receptor D1

Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.

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Dopamine receptor D2

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.

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Epinephrine, also known as adrenaline, is a medication, hormone and neurotransmitter.

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Europe is a continent that comprises the westernmost part of Eurasia.

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European Medicines Agency

The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.

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Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened and painful response to pressure.

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Finland (Suomi; Finland), officially the Republic of Finland, is a Nordic country in Northern Europe bordered by Sweden to the west, Norway to the north, and Russia to the east; Estonia lies to the south across the Gulf of Finland.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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France, officially the French Republic (République française), is a sovereign state comprising territory in western Europe and several overseas regions and territories.

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GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

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In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond.

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Histamine H1 receptor

The H1 receptor is a histamine receptor belonging to the family of Rhodopsin-like G-protein-coupled receptors.

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Imipramine (G 22355), sold as Tofranil and also known as melipramine, is a tricyclic antidepressant (TCA) of the dibenzazepine group.

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Japan (日本 Nippon or Nihon; formally or Nihon-koku, "State of Japan") is an island country in East Asia.

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The kidneys are bean-shaped organs that serve several essential regulatory roles in vertebrates.

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Laboratoires Pierre Fabre

Laboratoires Pierre Fabre is a French multinational pharmaceutical and cosmetics company.

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The liver is a vital organ of vertebrates and some other animals.

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Liver function tests

Liver function tests (LFTs or LFs) are groups of blood tests that give information about the state of a patient's liver.

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Major depressive disorder

Major depressive disorder (MDD) (also known as clinical depression, major depression, unipolar depression, or unipolar disorder; or as recurrent depression in the case of repeated episodes) is a mental disorder characterized by a pervasive and persistent low mood that is accompanied by low self-esteem and by a loss of interest or pleasure in normally enjoyable activities.

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Mania is the mood of an abnormally elevated arousal energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although it is often thought of as a "mirror image" to depression, the heightened mood can be either euphoric or irritable and, indeed, as the mania progresses, irritability becomes more prominent and can eventuate in violence.

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Mexico (México), officially the United Mexican States (Estados Unidos Mexicanos), is a federal republic in North America.

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Moclobemide (sold as Amira, Aurorix, Clobemix, Depnil and Manerix) is a reversible inhibitor of monoamine oxidase A (RIMA) drug primarily used to treat depression and social anxiety. It is not approved for use in the United States, but is approved in other Western countries such as the UK and Australia (TGA approved in December 2000). It is produced by affiliates of the Hoffmann–La Roche pharmaceutical company. Initially, Aurorix was also marketed by Roche in South Africa, but was withdrawn after its patent rights expired and Cipla Medpro's Depnil and Pharma Dynamic's Clorix became available at half the cost. No significant rise in blood pressure occurs when moclobemide is combined with amines such as tyramine-containing foods or pressor amine drugs, unlike with the older nonselective and irreversible monoamine oxidase inhibitors (MAOIs), which cause a severe rise in blood pressure with such combination. Due to the lack of anticholinergic, cardiovascular, cognitive and psychomotor impairments moclobemide is advantageous in the elderly as well as those with cardiovascular disease.

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Monoamine oxidase inhibitor

Monoamine oxidase inhibitors (MAOIs) are chemicals which inhibit the activity of the monoamine oxidase enzyme family.

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Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certain neurons and other cells.

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Myocardial infarction

Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle.

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Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Norepinephrine, also called noradrenaline, is an organic chemical in the catecholamine family that functions in the human brain and body as a hormone and neurotransmitter.

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Opioid receptor

Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.

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Phenelzine (Nardil, Nardelzine) is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class which is used as an antidepressant and anxiolytic.

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Portugal, officially the Portuguese Republic (República Portuguesa), is a country on the Iberian Peninsula, in southwestern Europe.

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Psychomotor agitation

Psychomotor agitation is a series of unintentional and purposeless motions that stem from mental tension and anxiety of an individual.

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Psychosis refers to an abnormal condition of the mind described as involving a "loss of contact with reality".

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule usually found embedded within the plasma membrane surface of a cell that receives chemical signals from outside the cell.

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Reuptake, or re-uptake, is the reabsorption of a neurotransmitter by a neurotransmitter transporter of a pre-synaptic neuron after it has performed its function of transmitting a neural impulse.

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Reuptake inhibitor

A reuptake inhibitor (RI) is a type of reuptake modulator which inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an increase in neurotransmission.

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Russia (Ru-Россия.ogg), also officially known as the Russian Federation (a), is a country in northern Eurasia.

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Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

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Selegiline (Anipryl, L-deprenyl, Eldepryl, Emsam, Zelapar) is a substituted phenethylamine used for the treatment of early-stage Parkinson's disease, depression and dementia.

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Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs), also known as serotonin-noradrenaline reuptake inhibitors, are a class of antidepressant drugs used in the treatment of major depressive disorder (MDD) and other mood disorders.

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Sleep is a naturally recurring state of mind characterized by altered consciousness, relatively inhibited sensory activity, inhibition of nearly all voluntary muscles, and reduced interactions with surroundings.

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Suicide crisis

A suicide crisis, suicidal crisis, attempted suicide or potential suicide, is a situation in which a person is attempting to kill him or herself or is seriously contemplating or planning to do so.

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Toloxatone (Humoryl) is an antidepressant launched in 1984 in France for the treatment of depression.

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Tranylcypromine (INN, USAN, BAN) (brand names: Parnate, Jatrosom (which is a brand solely sold in Germany)) is a monoamine oxidase inhibitor (MAOI)—it is a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO).

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Tricyclic antidepressant

Tricyclic antidepressants (TCAs) are chemical compounds used primarily as antidepressants.

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Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches.

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United States

The United States of America (USA), commonly referred to as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major territories and various possessions.

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Redirects here:

ATC code N06AX17, ATCvet code QN06AX17, F 2207, F-2207, F2207, Ixel, Midalcipran, Milnacepram, Milnacipram, Milnacipran Hydrochloride, Milnacipran hydrochloride, Savella, Toledomin.


[1] https://en.wikipedia.org/wiki/Milnacipran

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