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Molecular mimicry

Index Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. [1]

66 relations: Acetylcholine receptor, Adjuvant, Amino acid, Antibody, Antigen, Apoptosis, Arginine, Astrocyte, Autoantibody, Autoimmunity, Avidity, Axon, Azathioprine, B cell, Blood–brain barrier, Bone marrow, Central nervous system, Cerebrospinal fluid, Chameleon, Chemokine, Ciclosporin, Circulatory system, Clonal anergy, Clonal deletion, Convergent evolution, Cross-reactivity, Cysteine, Cytokine, Electrostatics, Epitope, Epstein–Barr virus, Escherichia coli, Etiology, Eukaryote, Fetus, Gp41, Hepatitis B, Herpes simplex virus, HIV/AIDS, Homology (chemistry), Horizontal gene transfer, Immune system, Immune tolerance, Immunosuppressive drug, Klaus Rajewsky, Lysine, Macrophage, Major histocompatibility complex, Mantis, Mitogen, ..., Myasthenia gravis, Myelin, Myelin oligodendrocyte glycoprotein, Neurotransmitter, Pathogen, Pathogenesis, Peptide, Protein, Proteolipid protein 1, Subtypes of HIV, Superantigen, T cell, T-cell receptor, UniProt, V(D)J recombination, Virus. Expand index (16 more) »

Acetylcholine receptor

An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.

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Adjuvant

An adjuvant is a pharmacological or immunological agent that modifies the effect of other agents.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Antigen

In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Arginine

Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.

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Astrocyte

Astrocytes (Astro from Greek astron.

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Autoantibody

An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins.

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Autoimmunity

Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues.

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Avidity

In biochemistry, avidity refers to the accumulated strength of multiple affinities of individual non-covalent binding interactions, such as between a protein receptor and its ligand, and is commonly referred to as functional affinity.

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Axon

An axon (from Greek ἄξων áxōn, axis) or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that typically conducts electrical impulses known as action potentials, away from the nerve cell body.

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Azathioprine

Azathioprine (AZA), sold under the brand name Imuran among others, is an immunosuppressive medication.

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B cell

B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.

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Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).

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Bone marrow

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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Cerebrospinal fluid

Cerebrospinal fluid (CSF) is a clear, colorless body fluid found in the brain and spinal cord.

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Chameleon

Chameleons or chamaeleons (family Chamaeleonidae) are a distinctive and highly specialized clade of Old World lizards with 202 species described as of June 2015.

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Chemokine

Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells.

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Ciclosporin

Ciclosporin, also spelled cyclosporine and cyclosporin, is an immunosuppressant medication and natural product.

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Circulatory system

The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.

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Clonal anergy

Anergy is a term in immunobiology that describes a lack of reaction by the body's defense mechanisms to foreign substances, and consists of a direct induction of peripheral lymphocyte tolerance.

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Clonal deletion

Clonal deletion is the removal through apoptosis of B cells and T cells that have expressed receptors for self before developing into fully immunocompetent lymphocytes.

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Convergent evolution

Convergent evolution is the independent evolution of similar features in species of different lineages.

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Cross-reactivity

Cross-reactivity, in a general sense, applies to the reaction between two different species as opposed to self-reactivity.

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Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Electrostatics

Electrostatics is a branch of physics that studies electric charges at rest.

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Epitope

An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells.

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Epstein–Barr virus

The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.

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Escherichia coli

Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).

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Etiology

Etiology (alternatively aetiology or ætiology) is the study of causation, or origination.

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Eukaryote

Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).

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Fetus

A fetus is a stage in the prenatal development of viviparous organisms.

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Gp41

Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV).

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Hepatitis B

Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver.

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Herpes simplex virus

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the herpesvirus family, Herpesviridae, that infect humans.

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HIV/AIDS

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).

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Homology (chemistry)

In chemistry, homology is the appearance of homologues.

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Horizontal gene transfer

Horizontal gene transfer (HGT) or lateral gene transfer (LGT) is the movement of genetic material between unicellular and/or multicellular organisms other than by the ("vertical") transmission of DNA from parent to offspring.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Immune tolerance

Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to substances or tissue that have the capacity to elicit an immune response in given organism.It is induced by prior exposure to that specific antigen.

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Immunosuppressive drug

Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system.

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Klaus Rajewsky

Klaus Rajewsky (born 12 November 1936 in Frankfurt) is a German immunologist, renowned for his work on B cells.

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Lysine

Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.

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Macrophage

Macrophages (big eaters, from Greek μακρός (makrós).

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Major histocompatibility complex

The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.

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Mantis

Mantises are an order (Mantodea) of insects that contains over 2,400 species in about 430 genera in 15 families.

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Mitogen

A mitogen is a chemical substance that encourages a cell to commence cell division, triggering mitosis.

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Myasthenia gravis

Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness.

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Myelin

Myelin is a lipid-rich substance that surrounds the axon of some nerve cells, forming an electrically insulating layer.

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Myelin oligodendrocyte glycoprotein

Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system (CNS).

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Pathogen

In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.

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Pathogenesis

The pathogenesis of a disease is the biological mechanism (or mechanisms) that leads to the diseased state.

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Peptide

Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Proteolipid protein 1

Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP).

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Subtypes of HIV

One of the obstacles to treatment of the human immunodeficiency virus is its high genetic variability.

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Superantigen

Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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T-cell receptor

The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

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UniProt

UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects.

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V(D)J recombination

V(D)J recombination is the unique mechanism of genetic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation.

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Virus

A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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Redirects here:

Antigenic mimickry, Antigenic mimicry.

References

[1] https://en.wikipedia.org/wiki/Molecular_mimicry

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