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Metapristone

Index Metapristone

Metapristone (developmental code name RU-42633; also known as desmethylmifepristone) is the major metabolite of mifepristone (RU-486, RU-38486) and a selective progesterone receptor modulator (SPRM) which itself was never marketed. [1]

13 relations: Cancer, Chemotherapy, CYP3A4, Demethylation, Enzyme, Glucocorticoid receptor, Ligand (biochemistry), Liver, Metabolite, Metastasis, Mifepristone, Progesterone receptor, Selective progesterone receptor modulator.

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.

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Demethylation

Demethylation is the chemical process resulting in the removal of a methyl group (CH3) from a molecule.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Glucocorticoid receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Metabolite

A metabolite is the intermediate end product of metabolism.

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Metastasis

Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor.

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Mifepristone

Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol, to bring about an abortion.

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Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

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Selective progesterone receptor modulator

A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor.

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Redirects here:

C28H33NO2, Demethylmifepristone, Desmethylmifepristone, Monodemethylmifepristone, Monodesmethylmifepristone, N-Demethylmifepristone, N-Desmethylmifepristone, N-demethylmifepristone, N-desmethylmifepristone, R 42,633, R 42633, R-42,633, R-42633, R42633, RU 42,633, RU 42633, RU-42,633, RU-42633, RU42633.

References

[1] https://en.wikipedia.org/wiki/Metapristone

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