Morphine-3-glucuronide

Morphine-3-glucuronide is a metabolite of morphine produced by UGT2B7. ^[1]

21 relations: Agonist, Blood–brain barrier, Buprenorphine-3-glucuronide, Coma, Convulsant, GABA receptor, Glycine receptor, Hallucination, Hyperalgesia, Kidney failure, Metabolite, Morphine, Morphine-6-glucuronide, Morphine-N-oxide, Opioid receptor, P-glycoprotein, Probenecid, Psychomotor agitation, Seizure, UGT2B7, 3-Monoacetylmorphine.
Glucuronide esters
Opioid metabolites

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.

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Buprenorphine-3-glucuronide

Buprenorphine-3-glucuronide (B3G) is a major active metabolite of the opioid modulator buprenorphine. Morphine-3-glucuronide and buprenorphine-3-glucuronide are Analgesic stubs, Glucuronide esters, opioid metabolites and Secondary alcohols.

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Coma

A coma is a deep state of prolonged unconsciousness in which a person cannot be awakened, fails to respond normally to painful stimuli, light, or sound, lacks a normal wake-sleep cycle and does not initiate voluntary actions.

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Convulsant

A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. Morphine-3-glucuronide and convulsant are convulsants.

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GABA receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.

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Glycine receptor

The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine.

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Hallucination

A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality.

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Hyperalgesia

Hyperalgesia (or; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus.

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Kidney failure

Kidney failure, also known as end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as either acute kidney failure, which develops rapidly and may resolve; and chronic kidney failure, which develops slowly and can often be irreversible.

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Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Morphine

Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum). Morphine-3-glucuronide and Morphine are GABAA receptor negative allosteric modulators and glycine receptor antagonists.

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Morphine-6-glucuronide

Morphine-6-glucuronide (M6G) is a major active metabolite of morphine. Morphine-3-glucuronide and morphine-6-glucuronide are Glucuronide esters and opioid metabolites.

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Morphine-N-oxide

Morphine-N-oxide (genomorphine) is an active opioid metabolite of morphine. Morphine-3-glucuronide and morphine-N-oxide are Analgesic stubs and opioid metabolites.

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Opioid receptor

Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.

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P-glycoprotein

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.

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Probenecid

Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine.

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Psychomotor agitation

Psychomotor agitation is a symptom in various disorders and health conditions.

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Seizure

A seizure is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

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UGT2B7

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

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3-Monoacetylmorphine

3-Monoacetylmorphine (3-MAM) or 3-acetylmorphine is a less active metabolite of heroin (diacetylmorphine), the other two being morphine and more active 6-monoacetylmorphine (6-MAM). Morphine-3-glucuronide and 3-Monoacetylmorphine are opioid metabolites.

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References

[1] https://en.wikipedia.org/wiki/Morphine-3-glucuronide

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