Morphine-6-glucuronide

Morphine-6-glucuronide (M6G) is a major active metabolite of morphine. ^[1]

Analgesic

An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.

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Codeine-6-glucuronide (C6G) is a major active metabolite of codeine and may be responsible for as much as 60% of the analgesic effects of codeine. Morphine-6-glucuronide and codeine-6-glucuronide are Glucuronide esters, mu-opioid receptor agonists, opioid metabolites and Phenols.

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High-performance liquid chromatography

High-performance liquid chromatography (HPLC), formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify specific components in mixtures.

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Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

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Kidney failure

Kidney failure, also known as end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as either acute kidney failure, which develops rapidly and may resolve; and chronic kidney failure, which develops slowly and can often be irreversible.

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Kidney transplantation

Kidney transplant or renal transplant is the organ transplant of a kidney into a patient with end-stage kidney disease (ESRD).

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Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Morphine

Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum). Morphine-6-glucuronide and Morphine are mu-opioid receptor agonists.

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Morphine-3-glucuronide

Morphine-3-glucuronide is a metabolite of morphine produced by UGT2B7. Morphine-6-glucuronide and morphine-3-glucuronide are Glucuronide esters and opioid metabolites.

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Morphine-N-oxide

Morphine-N-oxide (genomorphine) is an active opioid metabolite of morphine. Morphine-6-glucuronide and morphine-N-oxide are mu-opioid receptor agonists, opioid metabolites and Phenols.

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St Bartholomew's Hospital

St Bartholomew's Hospital, commonly known as Barts, is a teaching hospital located in the City of London.

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UGT2B7

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

See Morphine-6-glucuronide and UGT2B7

References

[1] https://en.wikipedia.org/wiki/Morphine-6-glucuronide

Also known as M6G, Morphine glucuronide.

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