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Multiple sclerosis

Index Multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. [1]

242 relations: Action potential, Acupuncture, Acute myeloid leukemia, Adverse effect, Alemtuzumab, Allele, Alternative medicine, Amaurosis fugax, Antibody, Apoptosis, Astrogliosis, Ataxia, Augustus d'Este, Autoimmune disease, Autonomic nervous system, Autopsy, Axon, Balo concentric sclerosis, Basal ganglia, Biomarker, Biopsy, Blood–brain barrier, Blurred vision, Bradycardia, Brainstem, Capillary, CD20, CD68, Central nervous system, Cerebrospinal fluid, Cholesterol crystal, Chromosome, Chromosome 6, Chronic cerebrospinal venous insufficiency, Chronic pain, Clinically isolated syndrome, Clonus, Cognitive behavioral therapy, Combination therapy, Common cold, Contrast agent, Corticosteroid, Cure, Cytokine, Daclizumab, Demyelinating disease, Diabetes mellitus type 1, Diet (nutrition), Diffuse myelinoclastic sclerosis, Dimethyl fumarate, ..., Diplopia, Disabilities affecting intellectual abilities, Disability, Dysarthria, Dysphagia, Edema, Eduard von Rindfleisch, Electrophoresis, Encephalomyelitis, Epstein–Barr virus, Equator, Erectile dysfunction, Estriol, Evoked potential, Expanded Disability Status Scale, Fatigue, Fetuin, Fingolimod, Functional magnetic resonance imaging, Gadolinium, Gastroenteritis, Gene, Genetic predisposition, Genetics, Genome-wide association study, Glatiramer acetate, Glial scar, Gout, Grey matter, Heart failure, Helminthic therapy, Hepatotoxicity, Herbalism, Heredity, Herpesviridae, HLA-C, HLA-DQ6, HLA-DR15, HLA-DRB1, Hormone, Human brain, Human leukocyte antigen, Humanized antibody, Hutterites, Hygiene hypothesis, Hyperbaric medicine, Hypertension, Hypoesthesia, Iceland, Immune disorder, Immune-mediated inflammatory diseases, Immunology, Indigenous peoples of the Americas, Infertility, Inflammation, Inflammatory demyelinating diseases of the central nervous system, Influenza, Influenza-like illness, Intention tremor, Intercurrent disease in pregnancy, Interdisciplinarity, Interferon, Interferon beta-1a, Interferon beta-1b, Interleukin 6, Intravenous therapy, Inuit, JC virus, Jean Cruveilhier, Jean-Martin Charcot, KCNJ10, Lady Augusta Murray, Laquinimod, Lhermitte's sign, Lidwina, Life expectancy, Lipoatrophy, List of multiple sclerosis organizations, List of people with multiple sclerosis, Locus (genetics), Lumbar puncture, Lymphocyte, Lymphocytopenia, Macrophage, Macular edema, Magnetic resonance imaging, Magnetization transfer, Major depressive disorder, Major histocompatibility complex, Malignant multiple sclerosis, Marburg acute multiple sclerosis, Māori people, McDonald criteria, Measles, Medical cannabis, Medical imaging, Medical sign, Methylprednisolone, Microorganism, Mindfulness, Mitoxantrone, Monoclonal antibody, Multiple sclerosis functional composite, Multiple Sclerosis International Federation, Mumps, Myelin, N-Acetylaspartic acid, Natalizumab, National Multiple Sclerosis Society, Netherlands, Neurofilament, Neuroimaging, Neurology, Neuromyelitis optica, Neuron, Neuroprotection, Neurorehabilitation, Neutropenia, Nitric oxide, Nitric oxide synthase, Nun, Nystagmus, Ocrelizumab, Ofatumumab, Oligoclonal band, Oligodendrocyte, Optic nerve, Optic neuritis, Osteopontin, Ozanimod, Pain, Palestinians, Paolo Zamboni, Paresthesia, Parsi, Pathology, PEGylation, Pen name, Peripheral nervous system, Phenotype (clinical medicine), Physical therapy, Plasmapheresis, Poser criteria, Positron emission tomography, Prediction, Prince Augustus Frederick, Duke of Sussex, Progressive multifocal leukoencephalopathy, Pseudobulbar affect, Radioactive tracer, Reflexology, Relapse, Relaxation technique, Remyelination, Rituximab, Robert Carswell (pathologist), Rubella, Sami people, Sardinian people, Schiedam, Schumacher criteria, Science (journal), Sensation (psychology), Sensory neuron, Sequela, Sicily, Solvent, Spasm, Spinal cord, Stem-cell therapy, Stress (biology), Suicide, Symptom, Systemic lupus erythematosus, T cell, Tau protein, Telegraphic speech, Teratology, Teriflunomide, Tobacco smoking, Toxin, Twin, Uhthoff's phenomenon, Uric acid, Vaccine, Ventricular system, Viral disease, Visual impairment, Vitamin D, W. N. P. Barbellion, WebMD, White matter, Yoga. Expand index (192 more) »

Action potential

In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.

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Acupuncture is a form of alternative medicine in which thin needles are inserted into the body.

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Acute myeloid leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.

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Adverse effect

In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery.

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Alemtuzumab is a drug used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma under the trade names Campath, MabCampath and Campath-1H, and in the treatment of multiple sclerosis as Lemtrada.

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An allele is a variant form of a given gene.

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Alternative medicine

Alternative medicine, fringe medicine, pseudomedicine or simply questionable medicine is the use and promotion of practices which are unproven, disproven, impossible to prove, or excessively harmful in relation to their effect — in the attempt to achieve the healing effects of medicine.--> --> --> They differ from experimental medicine in that the latter employs responsible investigation, and accepts results that show it to be ineffective. The scientific consensus is that alternative therapies either do not, or cannot, work. In some cases laws of nature are violated by their basic claims; in some the treatment is so much worse that its use is unethical. Alternative practices, products, and therapies range from only ineffective to having known harmful and toxic effects.--> Alternative therapies may be credited for perceived improvement through placebo effects, decreased use or effect of medical treatment (and therefore either decreased side effects; or nocebo effects towards standard treatment),--> or the natural course of the condition or disease. Alternative treatment is not the same as experimental treatment or traditional medicine, although both can be misused in ways that are alternative. Alternative or complementary medicine is dangerous because it may discourage people from getting the best possible treatment, and may lead to a false understanding of the body and of science.-->---> Alternative medicine is used by a significant number of people, though its popularity is often overstated.--> Large amounts of funding go to testing alternative medicine, with more than US$2.5 billion spent by the United States government alone.--> Almost none show any effect beyond that of false treatment,--> and most studies showing any effect have been statistical flukes. Alternative medicine is a highly profitable industry, with a strong lobby. This fact is often overlooked by media or intentionally kept hidden, with alternative practice being portrayed positively when compared to "big pharma". --> The lobby has successfully pushed for alternative therapies to be subject to far less regulation than conventional medicine.--> Alternative therapies may even be allowed to promote use when there is demonstrably no effect, only a tradition of use. Regulation and licensing of alternative medicine and health care providers varies between and within countries. Despite laws making it illegal to market or promote alternative therapies for use in cancer treatment, many practitioners promote them.--> Alternative medicine is criticized for taking advantage of the weakest members of society.--! Terminology has shifted over time, reflecting the preferred branding of practitioners.. Science Based Medicine--> For example, the United States National Institutes of Health department studying alternative medicine, currently named National Center for Complementary and Integrative Health, was established as the Office of Alternative Medicine and was renamed the National Center for Complementary and Alternative Medicine before obtaining its current name. Therapies are often framed as "natural" or "holistic", in apparent opposition to conventional medicine which is "artificial" and "narrow in scope", statements which are intentionally misleading. --> When used together with functional medical treatment, alternative therapies do not "complement" (improve the effect of, or mitigate the side effects of) treatment.--> Significant drug interactions caused by alternative therapies may instead negatively impact functional treatment, making it less effective, notably in cancer.--> Alternative diagnoses and treatments are not part of medicine, or of science-based curricula in medical schools, nor are they used in any practice based on scientific knowledge or experience.--> Alternative therapies are often based on religious belief, tradition, superstition, belief in supernatural energies, pseudoscience, errors in reasoning, propaganda, fraud, or lies.--> Alternative medicine is based on misleading statements, quackery, pseudoscience, antiscience, fraud, and poor scientific methodology. Promoting alternative medicine has been called dangerous and unethical.--> Testing alternative medicine that has no scientific basis has been called a waste of scarce research resources.--> Critics state that "there is really no such thing as alternative medicine, just medicine that works and medicine that doesn't",--> that the very idea of "alternative" treatments is paradoxical, as any treatment proven to work is by definition "medicine".-->.

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Amaurosis fugax

Amaurosis fugax (Latin fugax meaning fleeting, Greek amaurosis meaning darkening, dark, or obscure) is a painless temporary loss of vision in one or both eyes.

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An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Astrogliosis (also known as astrocytosis or referred to as reactive astrocytosis) is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons from CNS trauma, infection, ischemia, stroke, autoimmune responses, and neurodegenerative disease.

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Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that includes gait abnormality.

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Augustus d'Este

Sir Augustus Frederick d'Este, KCH (13 January 1794 – 28 December 1848) was a relative of the British royal family and the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made.

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Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.

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Autonomic nervous system

The autonomic nervous system (ANS), formerly the vegetative nervous system, is a division of the peripheral nervous system that supplies smooth muscle and glands, and thus influences the function of internal organs.

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An autopsy (post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a highly specialized surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause and manner of death or to evaluate any disease or injury that may be present for research or educational purposes.

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An axon (from Greek ἄξων áxōn, axis) or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that typically conducts electrical impulses known as action potentials, away from the nerve cell body.

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Balo concentric sclerosis

Balo concentric sclerosis is a disease in which the white matter of the brain appears damaged in concentric layers, leaving the axis cylinder intact.

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Basal ganglia

The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.

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A biomarker, or biological marker, generally refers to a measurable indicator of some biological state or condition.

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A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease.

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Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).

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Blurred vision

Blurred vision is an ocular symptom.

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Bradycardia is a condition wherein an individual has a very slow heart rate, typically defined as a resting heart rate of under 60 beats per minute (BPM) in adults.

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The brainstem (or brain stem) is the posterior part of the brain, adjoining and structurally continuous with the spinal cord.

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A capillary is a small blood vessel from 5 to 10 micrometres (µm) in diameter, and having a wall one endothelial cell thick.

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B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity.

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CD68 ('''C'''luster of '''D'''ifferentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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Cerebrospinal fluid

Cerebrospinal fluid (CSF) is a clear, colorless body fluid found in the brain and spinal cord.

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Cholesterol crystal

A cholesterol crystal is a solid, crystalline form of cholesterol found in gallstones and atherosclerosis.

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A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.

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Chromosome 6

Chromosome 6 is one of the 23 pairs of chromosomes in humans.

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Chronic cerebrospinal venous insufficiency

Chronic cerebrospinal venous insufficiency (CCSVI or CCVI) is a term developed by Italian researcher Paolo Zamboni in 2008 to describe compromised flow of blood in the veins draining the central nervous system.

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Chronic pain

Chronic pain is pain that lasts a long time.

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Clinically isolated syndrome

A clinically isolated syndrome (CIS) is a clinical situation of an individual's first neurological episode, caused by inflammation or demyelination of nerve tissue.

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Clonus (from the Greek for "violent, confused motion") is a series of involuntary, rhythmic, muscular contractions and relaxations.

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Cognitive behavioral therapy

Cognitive-behavioral therapy (CBT) is a psycho-social intervention that is the most widely used evidence-based practice aimed at improving mental health.

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Combination therapy

Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone).

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Common cold

The common cold, also known simply as a cold, is a viral infectious disease of the upper respiratory tract that primarily affects the nose.

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Contrast agent

A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging.

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Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.

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A cure is a substance or procedure that ends a medical condition, such as a medication, a surgical operation, a change in lifestyle or even a philosophical mindset that helps end a person's sufferings; or the state of being healed, or cured.

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Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Daclizumab (trade name Zinbryta, by Biogen) is a therapeutic humanized monoclonal antibody which was used for the treatment of adults with relapsing forms of multiple sclerosis (MS).

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Demyelinating disease

A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged.

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Diabetes mellitus type 1

Diabetes mellitus type 1, also known as type 1 diabetes, is a form of diabetes mellitus in which not enough insulin is produced.

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Diet (nutrition)

In nutrition, diet is the sum of food consumed by a person or other organism.

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Diffuse myelinoclastic sclerosis

Diffuse myelinoclastic sclerosis, sometimes referred to as Schilder's disease, is a very infrequent neurodegenerative disease that presents clinically as pseudotumoural demyelinating lesions, that make its diagnosis difficult.

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Dimethyl fumarate

Dimethyl fumarate (DMF) is the methyl ester of fumaric acid.

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Diplopia, commonly known as double vision, is the simultaneous perception of two images of a single object that may be displaced horizontally, vertically, diagonally (i.e., both vertically and horizontally), or rotationally in relation to each other.

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Disabilities affecting intellectual abilities

There are a variety of medical conditions affecting cognitive ability.

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A disability is an impairment that may be cognitive, developmental, intellectual, mental, physical, sensory, or some combination of these.

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Dysarthria is a motor speech disorder resulting from neurological injury of the motor component of the motor-speech system and is characterized by poor articulation of phonemes.

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Dysphagia is the medical term for the symptom of difficulty in swallowing.

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Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.

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Eduard von Rindfleisch

Georg Eduard von Rindfleisch (15 December 1836 – 6 December 1908) was a German pathologist and histologist.

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Electrophoresis (from the Greek "Ηλεκτροφόρηση" meaning "to bear electrons") is the motion of dispersed particles relative to a fluid under the influence of a spatially uniform electric field.

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Encephalomyelitis is inflammation of the brain and spinal cord.

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Epstein–Barr virus

The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.

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An equator of a rotating spheroid (such as a planet) is its zeroth circle of latitude (parallel).

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Erectile dysfunction

Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity.

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Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone.

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Evoked potential

An evoked potential or evoked response is an electrical potential recorded from the nervous system of a human or other animal following presentation of a stimulus, as distinct from spontaneous potentials as detected by electroencephalography (EEG), electromyography (EMG), or other electrophysiologic recording method.

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Expanded Disability Status Scale

The Kurtzke Expanded Disability Status Scale (EDSS) is a method of quantifying disability in multiple sclerosis.

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Fatigue is a subjective feeling of tiredness that has a gradual onset.

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Fetuins are blood proteins that are made in the liver and secreted into the bloodstream.

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Fingolimod (INN, trade name Gilenya, Novartis) is an immunomodulating drug, mostly used for treating multiple sclerosis (MS).

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Functional magnetic resonance imaging

Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow.

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Gadolinium is a chemical element with symbol Gd and atomic number 64.

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Gastroenteritis, also known as infectious diarrhea, is inflammation of the gastrointestinal tract -- the stomach and small intestine.

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Genetic predisposition

A genetic predisposition is a genetic characteristic which influences the possible phenotypic development of an individual organism within a species or population under the influence of environmental conditions.

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Genetics is the study of genes, genetic variation, and heredity in living organisms.

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Genome-wide association study

In genetics, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait.

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Glatiramer acetate

Glatiramer acetate (also known as Copolymer 1, Cop-1, or Copaxone) is an immunomodulator medication currently used to treat multiple sclerosis.

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Glial scar

Glial scar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system.

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Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint.

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Grey matter

Grey matter (or gray matter) is a major component of the central nervous system, consisting of neuronal cell bodies, neuropil (dendrites and myelinated as well as unmyelinated axons), glial cells (astrocytes and oligodendrocytes), synapses, and capillaries.

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Heart failure

Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.

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Helminthic therapy

Helminthic therapy, an experimental type of immunotherapy, is the treatment of autoimmune diseases and immune disorders by means of deliberate infestation with a helminth or with the ova of a helminth.

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Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

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Herbalism (also herbal medicine or phytotherapy) is the study of botany and use of plants intended for medicinal purposes or for supplementing a diet.

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Heredity is the passing on of traits from parents to their offspring, either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic information of their parents.

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Herpesviridae is a large family of DNA viruses that cause diseases in animals, including humans.

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HLA-C belongs to the MHC (human.

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HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group.

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HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products.

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HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene.

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A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Human brain

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system.

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Human leukocyte antigen

The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans.

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Humanized antibody

Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants produced naturally in humans.

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Hutterites (Hutterer) are an ethnoreligious group that is a communal branch of Anabaptists who, like the Amish and Mennonites, trace their roots to the Radical Reformation of the 16th century.

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Hygiene hypothesis

In medicine, the hygiene hypothesis states a lack of early childhood exposure to infectious agents, symbiotic microorganisms (such as the gut flora or probiotics), and parasites increases susceptibility to allergic diseases by suppressing the natural development of the immune system.

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Hyperbaric medicine

Hyperbaric medicine is medical treatment in which an ambient pressure greater than sea level atmospheric pressure is a necessary component.

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Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Hypoesthesia (also spelled as hypesthesia) is a common side effect of various medical conditions which manifests as a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli.

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Iceland is a Nordic island country in the North Atlantic, with a population of and an area of, making it the most sparsely populated country in Europe.

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Immune disorder

An immune disorder is a dysfunction of the immune system.

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Immune-mediated inflammatory diseases

An immune-mediated inflammatory disease (IMID) is any of a group of conditions or diseases that lack a definitive etiology, but which are characterized by common inflammatory pathways leading to inflammation, and which may result from, or be triggered by, a dysregulation of the normal immune response.

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Immunology is a branch of biology that covers the study of immune systems in all organisms.

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Indigenous peoples of the Americas

The indigenous peoples of the Americas are the pre-Columbian peoples of the Americas and their descendants. Although some indigenous peoples of the Americas were traditionally hunter-gatherers—and many, especially in the Amazon basin, still are—many groups practiced aquaculture and agriculture. The impact of their agricultural endowment to the world is a testament to their time and work in reshaping and cultivating the flora indigenous to the Americas. Although some societies depended heavily on agriculture, others practiced a mix of farming, hunting and gathering. In some regions the indigenous peoples created monumental architecture, large-scale organized cities, chiefdoms, states and empires. Many parts of the Americas are still populated by indigenous peoples; some countries have sizable populations, especially Belize, Bolivia, Canada, Chile, Ecuador, Greenland, Guatemala, Guyana, Mexico, Panama and Peru. At least a thousand different indigenous languages are spoken in the Americas. Some, such as the Quechuan languages, Aymara, Guaraní, Mayan languages and Nahuatl, count their speakers in millions. Many also maintain aspects of indigenous cultural practices to varying degrees, including religion, social organization and subsistence practices. Like most cultures, over time, cultures specific to many indigenous peoples have evolved to incorporate traditional aspects but also cater to modern needs. Some indigenous peoples still live in relative isolation from Western culture, and a few are still counted as uncontacted peoples.

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Infertility is the inability of a person, animal or plant to reproduce by natural means.

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Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Inflammatory demyelinating diseases of the central nervous system

Inflammatory demyelinating diseases (IDDs), sometimes called Idiopathic (IIDDs) because the unknown etiology of some of them, and sometimes known as borderline forms of multiple sclerosis, is a collection of multiple sclerosis variants, sometimes considered different diseases, but considered by others to form a spectrum differing only in terms of chronicity, severity, and clinical course.

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Influenza, commonly known as "the flu", is an infectious disease caused by an influenza virus.

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Influenza-like illness

Influenza-like illness (ILI), also known as acute respiratory infection (ARI) and flu-like syndrome/symptoms, is a medical diagnosis of possible influenza or other illness causing a set of common symptoms.

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Intention tremor

Intention tremor, also known as cerebellar tremor, is a dyskinetic disorder characterized by a broad, coarse, and low frequency (below 5 Hz) tremor.

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Intercurrent disease in pregnancy

An intercurrent (or concurrent, concomitant or, in most cases, pre-existing) disease in pregnancy is a disease that is not directly caused by the pregnancy (in contrast to a complication of pregnancy), but which may become worse or be a potential risk to the pregnancy (such as causing pregnancy complications).

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Interdisciplinarity or interdisciplinary studies involves the combining of two or more academic disciplines into one activity (e.g., a research project).

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Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells.

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Interferon beta-1a

Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS).

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Interferon beta-1b

Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS).

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Interleukin 6

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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The Inuit (ᐃᓄᐃᑦ, "the people") are a group of culturally similar indigenous peoples inhabiting the Arctic regions of Greenland, Canada and Alaska.

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JC virus

The JC virus or John Cunningham virus is a type of human polyomavirus (formerly known as papovavirus).

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Jean Cruveilhier

Jean Cruveilhier (February 9, 1791 – March 7, 1874) was a French anatomist and pathologist.

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Jean-Martin Charcot

Jean-Martin Charcot (29 November 1825 – 16 August 1893) was a French neurologist and professor of anatomical pathology.

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ATP-sensitive inward rectifier potassium channel 10 is a protein that in humans is encoded by the KCNJ10 gene.

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Lady Augusta Murray

Lady Augusta Murray (27 January 1768 – 5 March 1830) was the first wife of Prince Augustus Frederick, Duke of Sussex, the sixth son of George III.

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Laquinimod is an experimental immunomodulator developed by Active Biotech and Teva.

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Lhermitte's sign

Lhermitte's phenomenon or the Lhermitte phenomenon, sometimes called the barber chair phenomenon, is an uncomfortable electrical sensation that runs through the back and into the limbs.

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Lidwina (Lydwine, Lydwid, Lidwid, Liduina of Schiedam) was a Dutch mystic who is honored as a saint by the Catholic Church.

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Life expectancy

Life expectancy is a statistical measure of the average time an organism is expected to live, based on the year of its birth, its current age and other demographic factors including gender.

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Lipoatrophy is the term describing the localized loss of fat tissue.

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List of multiple sclerosis organizations

List of Multiple Sclerosis Organizations in different countries around the world.

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List of people with multiple sclerosis

This is a list of people with multiple sclerosis with sources and explanations.

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Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

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Lumbar puncture

Lumbar puncture (LP), also known as a spinal tap, is a medical procedure in which a needle is inserted into the spinal canal, most commonly to collect cerebrospinal fluid (CSF) for diagnostic testing.

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A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Lymphocytopenia, or lymphopenia, is the condition of having an abnormally low level of lymphocytes in the blood.

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Macrophages (big eaters, from Greek μακρός (makrós).

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Macular edema

Macular edema occurs when fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken and swell (edema).

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Magnetic resonance imaging

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body in both health and disease.

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Magnetization transfer

Magnetization transfer (MT), in NMR and MRI, refers to the transfer of nuclear spin polarization and/or spin coherence from one population of nuclei to another population of nuclei, and to techniques that make use of these phenomena.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Major histocompatibility complex

The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.

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Malignant multiple sclerosis

The term malignant multiple sclerosis is used to describe MS patients who reach significant level of disability in a short period of time.

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Marburg acute multiple sclerosis

Marburg acute multiple sclerosis, also known as Marburg multiple sclerosis or acute fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases.

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Māori people

The Māori are the indigenous Polynesian people of New Zealand.

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McDonald criteria

The McDonald criteria are diagnostic criteria for multiple sclerosis (MS).

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Measles is a highly contagious infectious disease caused by the measles virus.

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Medical cannabis

Medical cannabis, or medical marijuana, is cannabis and cannabinoids that are recommended by doctors for their patients.

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Medical imaging

Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology).

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Medical sign

A medical sign is an objective indication of some medical fact or characteristic that may be detected by a patient or anyone, especially a physician, before or during a physical examination of a patient.

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Methylprednisolone, sold under the brand names Depo-Medrol and Solu-Medrol among others, is a corticosteroid medication used to suppress the immune system and decrease inflammation.

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A microorganism, or microbe, is a microscopic organism, which may exist in its single-celled form or in a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from 6th century BC India and the 1st century BC book On Agriculture by Marcus Terentius Varro. Microbiology, the scientific study of microorganisms, began with their observation under the microscope in the 1670s by Antonie van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera and anthrax. Microorganisms include all unicellular organisms and so are extremely diverse. Of the three domains of life identified by Carl Woese, all of the Archaea and Bacteria are microorganisms. These were previously grouped together in the two domain system as Prokaryotes, the other being the eukaryotes. The third domain Eukaryota includes all multicellular organisms and many unicellular protists and protozoans. Some protists are related to animals and some to green plants. Many of the multicellular organisms are microscopic, namely micro-animals, some fungi and some algae, but these are not discussed here. They live in almost every habitat from the poles to the equator, deserts, geysers, rocks and the deep sea. Some are adapted to extremes such as very hot or very cold conditions, others to high pressure and a few such as Deinococcus radiodurans to high radiation environments. Microorganisms also make up the microbiota found in and on all multicellular organisms. A December 2017 report stated that 3.45 billion year old Australian rocks once contained microorganisms, the earliest direct evidence of life on Earth. Microbes are important in human culture and health in many ways, serving to ferment foods, treat sewage, produce fuel, enzymes and other bioactive compounds. They are essential tools in biology as model organisms and have been put to use in biological warfare and bioterrorism. They are a vital component of fertile soils. In the human body microorganisms make up the human microbiota including the essential gut flora. They are the pathogens responsible for many infectious diseases and as such are the target of hygiene measures.

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Mindfulness is the psychological process of bringing one's attention to experiences occurring in the present moment,Mindfulness Training as a Clinical Intervention: A Conceptual and Empirical Review, by Ruth A. Baer, available at http://www.wisebrain.org/papers/MindfulnessPsyTx.pdf which can be developed through the practice of meditation and other training.

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Mitoxantrone (INN, BAN, USAN; also known as Mitozantrone in Australia; trade name Novantrone) is an anthracenedione antineoplastic agent.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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Multiple sclerosis functional composite

The multiple sclerosis functional composite is a method of measuring the severity of multiple sclerosis primarily used in research.

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Multiple Sclerosis International Federation

The Multiple Sclerosis International Federation (MSIF) was established in 1967 as an international body linking the activities of National MS societies around the world.

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Mumps is a viral disease caused by the mumps virus.

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Myelin is a lipid-rich substance that surrounds the axon of some nerve cells, forming an electrically insulating layer.

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N-Acetylaspartic acid

N-Acetylaspartic acid, or N-acetylaspartate (NAA), is a derivative of aspartic acid with a formula of C6H9NO5 and a molecular weight of 175.139.

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Natalizumab is a humanized monoclonal antibody against the cell adhesion molecule α4-integrin.

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National Multiple Sclerosis Society

The National Multiple Sclerosis Society (NMSS) is a non-profit organization based in New York City with chapters located throughout the United States.

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The Netherlands (Nederland), often referred to as Holland, is a country located mostly in Western Europe with a population of seventeen million.

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Neurofilaments (NF) are intermediate filaments found in the cytoplasm of neurons.

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Neuroimaging or brain imaging is the use of various techniques to either directly or indirectly image the structure, function/pharmacology of the nervous system.

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Neurology (from νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is a branch of medicine dealing with disorders of the nervous system.

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Neuromyelitis optica

Neuromyelitis optica (NMO), also known as Devic's disease or Devic's syndrome, is a heterogeneous condition consisting of the inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis).

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A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

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Neuroprotection refers to the relative preservation of neuronal structure and/or function.

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Neurorehabilitation is a complex medical process which aims to aid recovery from a nervous system injury, and to minimize and/or compensate for any functional alterations resulting from it.

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Neutropenia or neutropaenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.

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Nitric oxide

Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.

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Nitric oxide synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.

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A nun is a member of a religious community of women, typically living under vows of poverty, chastity, and obedience in the enclosure of a monastery.

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Nystagmus is a condition of involuntary (or voluntary, in rare cases) eye movement, acquired in infancy or later in life, that may result in reduced or limited vision.

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Ocrelizumab (trade name Ocrevus) is a humanized anti-CD20 monoclonal antibody.

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Ofatumumab (trade name Arzerra, also known as HuMax-CD20) is a fully human monoclonal antibody (for the CD20 protein) which appears to inhibit early-stage B lymphocyte activation.

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Oligoclonal band

Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patient's blood serum, or cerebrospinal fluid (CSF) is analyzed.

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Oligodendrocytes, or oligodendroglia,.

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Optic nerve

The optic nerve, also known as cranial nerve II, is a paired nerve that transmits visual information from the retina to the brain.

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Optic neuritis

Optic neuritis is a demyelinating inflammation of the optic nerve.

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Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).

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Ozanimod (RPC-1063) is an investigational immunomodulatory drug currently in phase III clinical trials for the therapy of relapsing multiple sclerosis (RMS) and ulcerative colitis (UC).

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Pain is a distressing feeling often caused by intense or damaging stimuli.

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The Palestinian people (الشعب الفلسطيني, ash-sha‘b al-Filasṭīnī), also referred to as Palestinians (الفلسطينيون, al-Filasṭīniyyūn, פָלַסְטִינִים) or Palestinian Arabs (العربي الفلسطيني, al-'arabi il-filastini), are an ethnonational group comprising the modern descendants of the peoples who have lived in Palestine over the centuries, including Jews and Samaritans, and who today are largely culturally and linguistically Arab.

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Paolo Zamboni

Paolo Zamboni (born 25 March 1957, Ferrara, Italy) is an Italian doctor who claims to have found in an unblinded preliminary study that in over 90% of the participants with multiple sclerosis there were problems in veins draining their brain, like stenosis or defective valves.

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Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.

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A Parsi (or Parsee) means "Persian" in the "Persian Language", which today mainly refers to a member of a Zoroastrian community, one of two (the other being Iranis) mainly located in India, with a few in Pakistan.

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Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering" and -logia (-λογία), "study of") is a significant field in modern medical diagnosis and medical research, concerned mainly with the causal study of disease, whether caused by pathogens or non-infectious physiological disorder.

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PEGylation (often styled pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated (pegylated).

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Pen name

A pen name (nom de plume, or literary double) is a pseudonym (or, in some cases, a variant form of a real name) adopted by an author and printed on the title page or by-line of their works in place of their "real" name.

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Peripheral nervous system

The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).

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Phenotype (clinical medicine)

In a nosological sense, the term phenotype can be used in clinical medicine for speaking about the presentation of a disease.

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Physical therapy

Physical therapy (PT), also known as physiotherapy, is one of the allied health professions that, by using mechanical force and movements (bio-mechanics or kinesiology), manual therapy, exercise therapy, and electrotherapy, remediates impairments and promotes mobility and function.

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Plasmapheresis (from the Greek πλάσμα—plasma, something molded, and ἀφαίρεσις—aphairesis, taking away) is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulation.

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Poser criteria

Poser criteria are diagnostic criteria for multiple sclerosis (MS).

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Positron emission tomography

Positron-emission tomography (PET) is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease.

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A prediction (Latin præ-, "before," and dicere, "to say"), or forecast, is a statement about a future event.

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Prince Augustus Frederick, Duke of Sussex

Prince Augustus Frederick, Duke of Sussex, (27 January 1773 – 21 April 1843) was the sixth son and ninth child of King George III and his consort Charlotte of Mecklenburg-Strelitz.

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Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is a rare and usually fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal).

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Pseudobulbar affect

Pseudobulbar affect (PBA), or emotional incontinence, is a type of emotional disturbance characterized by uncontrollable episodes of crying and/or laughing, or other emotional displays.

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Radioactive tracer

A radioactive tracer, or radioactive label, is a chemical compound in which one or more atoms have been replaced by a radionuclide so by virtue of its radioactive decay it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from reactants to products.

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Reflexology, also known as zone therapy, is an alternative medicine involving application of pressure to the feet and hands with specific thumb, finger, and hand techniques without the use of oil or lotion.

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In medicine, relapse or recidivism is a recurrence of a past (typically medical) condition.

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Relaxation technique

A relaxation technique (also known as relaxation training) is any method, process, procedure, or activity that helps a person to relax; to attain a state of increased calmness; or otherwise reduce levels of pain, anxiety, stress or anger.

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Remyelination is the process of propagating oligodendrocyte precursor cells to form oligodendrocytes to create new myelin sheaths on demyelinated axons in the CNS.

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Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer.

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Robert Carswell (pathologist)

Sir Robert Carswell (1793–1857) was a Scottish professor of pathology, who described and illustrated many of the clinical details of multiple sclerosis but did not identify it as a separate disease.

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Rubella, also known as German measles or three-day measles, is an infection caused by the rubella virus.

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Sami people

The Sami people (also known as the Sámi or the Saami) are a Finno-Ugric people inhabiting Sápmi, which today encompasses large parts of Norway and Sweden, northern parts of Finland, and the Murmansk Oblast of Russia.

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Sardinian people

The Sardinians, or also the Sards (Sardos or Sardus; Italian and Sassarese: Sardi; Catalan: Sards or Sardos; Gallurese: Saldi; Ligurian: Sordi), are the native people and ethnic group from which Sardinia, a western Mediterranean island and autonomous region of Italy, derives its name.

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Schiedam is a city and municipality in the province of South Holland in the Netherlands.

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Schumacher criteria

Multiple sclerosis, understood as a CNS condition, can be difficult to diagnose since its signs and symptoms may be similar to other medical problems.

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Science (journal)

Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.

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Sensation (psychology)

Sensation is the body's detection of external or internal stimulation (e.g., eyes detecting light waves, ears detecting sound waves).

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Sensory neuron

Sensory neurons also known as afferent neurons are neurons that convert a specific type of stimulus, via their receptors, into action potentials or graded potentials.

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A sequela (usually used in the plural, sequelae) is a pathological condition resulting from a disease, injury, therapy, or other trauma.

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Sicily (Sicilia; Sicìlia) is the largest island in the Mediterranean Sea.

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A solvent (from the Latin solvō, "loosen, untie, solve") is a substance that dissolves a solute (a chemically distinct liquid, solid or gas), resulting in a solution.

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A spasm is a sudden involuntary contraction of a muscle, a group of muscles, or a hollow organ such as the heart.

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Spinal cord

The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column.

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Stem-cell therapy

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.

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Stress (biology)

Physiological or biological stress is an organism's response to a stressor such as an environmental condition.

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Suicide is the act of intentionally causing one's own death.

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A symptom (from Greek σύμπτωμα, "accident, misfortune, that which befalls", from συμπίπτω, "I befall", from συν- "together, with" and πίπτω, "I fall") is a departure from normal function or feeling which is noticed by a patient, reflecting the presence of an unusual state, or of a disease.

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Systemic lupus erythematosus

Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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Tau protein

Tau proteins (or τ proteins, after the Greek letter with that name) are proteins that stabilize microtubules.

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Telegraphic speech

Telegraphic speech, according to linguistics and psychology, is speech during the two-word stage of language acquisition in children, which is laconic and efficient.

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Teratology is the study of abnormalities of physiological development.

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Teriflunomide (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide.

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Tobacco smoking

Tobacco smoking is the practice of smoking tobacco and inhaling tobacco smoke (consisting of particle and gaseous phases).

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A toxin (from toxikon) is a poisonous substance produced within living cells or organisms; synthetic toxicants created by artificial processes are thus excluded.

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Twins are two offspring produced by the same pregnancy.

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Uhthoff's phenomenon

Uhthoff's phenomenon (also known as Uhthoff's syndrome, Uhthoff's sign, and Uhthoff's symptom) is the worsening of neurologic symptoms in multiple sclerosis (MS) and other neurological, demyelinating conditions when the body gets overheated from hot weather, exercise, fever, or saunas and hot tubs.

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Uric acid

Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3.

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A vaccine is a biological preparation that provides active acquired immunity to a particular disease.

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Ventricular system

The ventricular system is a set of four interconnected cavities (ventricles) in the brain, where the cerebrospinal fluid (CSF) is produced.

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Viral disease

A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells.

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Visual impairment

Visual impairment, also known as vision impairment or vision loss, is a decreased ability to see to a degree that causes problems not fixable by usual means, such as glasses.

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Vitamin D

Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects.

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W. N. P. Barbellion

Wilhelm Nero Pilate Barbellion was the nom-de-plume of Bruce Frederick Cummings (7 September 1889 – 22 October 1919), an English diarist who was responsible for The Journal of a Disappointed Man.

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WebMD is an American corporation known primarily as an online publisher of news and information pertaining to human health and well-being.

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White matter

White matter refers to areas of the central nervous system (CNS) that are mainly made up of myelinated axons, also called tracts.

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Yoga (Sanskrit, योगः) is a group of physical, mental, and spiritual practices or disciplines which originated in ancient India.

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Action for Research into Multiple Sclerosis, Choreiform paralysis, Disseminated sclerosis, Encephalomyelitis disseminata, Herdsklerose, Insular sclerosis, La sclerose en plaques disseminées, La sclerose generalisée, La sclerose multiloculaire, Multilocular sclerosis, Multiple Sclerosis, Multiple hirnsklerose, Multiple inselformige sklerose, Multiple scelerosis, Multiple scelrosis, Multiple schlerosis, Multiple schlorosis, Multiple sklerose, Multiple sklerose des nervensystems, Polynesic sclerosis, Primary progressive multiple sclerosis, Primary-progressive MS, RRMS, Relapsing MS, Relapsing multiple sclerosis, Relapsing remitting MS, Relapsing remitting multiple sclerosis, Relapsing-remitting MS, Relapsing-remitting multiple sclerosis, Rhythmic chorea, Sclerose en plaques, Sclerose en plaques disseminees, Sclerosi in plache, Sclerosis Multiplex, Sclerosis disseminata, Sclerosis multiplex.


[1] https://en.wikipedia.org/wiki/Multiple_sclerosis

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