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NADH:ubiquinone oxidoreductase (H+-translocating)

Index NADH:ubiquinone oxidoreductase (H+-translocating)

NADH:ubiquinone oxidoreductase (also referred to as Type I NADH dehydrogenase and mitochondrial Complex I especially in humans) is an enzyme of the respiratory chains of myriad organisms from bacteria to humans. [1]

123 relations: Acetogenin, Activation energy, Adenosine diphosphate ribose, Adenosine triphosphate, Annonaceae, Antiporter, Apoptosis, Asimina triloba, Bovinae, Coenzyme Q – cytochrome c reductase, Coenzyme Q10, Cofactor (biochemistry), Competitive inhibition, Cysteine, Cytochrome c oxidase, Derris, Dihydroorotate dehydrogenase, DTNB, Electrochemical potential, Electron, Electron paramagnetic resonance, Electron transport chain, Electron-transferring flavoprotein, Enzyme, Escherichia coli, Fabaceae, Faboideae, Flavin adenine dinucleotide, Flavin group, Flavin mononucleotide, Flutamide, Glycerol-3-phosphate dehydrogenase, Heme, Hepatotoxicity, Human, Hydrogen peroxide, Hypoxia (medical), Iron–sulfur cluster, Isoflavonoid, Leber's hereditary optic neuropathy, Leigh syndrome, Loganiaceae, Lonchocarpus, Malic acid, Mammal, Metformin, Mitochondrial disease, Mitochondrial DNA, Mitochondrion, Mrp superfamily, ..., MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, Myocardial infarction, N-Ethylmaleimide, NADH dehydrogenase (ubiquinone), alpha 1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFAF1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, Nefazodone, Nicotinamide adenine dinucleotide, Nitric oxide, Oxaloacetic acid, Paracoccus denitrificans, Parkinson's disease, Peroxynitrite, Pfam, Piericidin A, Programmed cell death, Proton pump, Reactive oxygen species, Reperfusion injury, Rhodothermus marinus, Rotenone, Schizosaccharomyces pombe, Semiquinone, Stroke, Succinate dehydrogenase, Succinic acid, Superoxide, Ubiquinol, UniProt, Water potential. Expand index (73 more) »

Acetogenin

Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae.

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Activation energy

In chemistry and physics, activation energy is the energy which must be available to a chemical or nuclear system with potential reactants to result in: a chemical reaction, nuclear reaction, or other various other physical phenomena.

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Adenosine diphosphate ribose

Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase.

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Adenosine triphosphate

Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.

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Annonaceae

The Annonaceae are a family, the custard apple family, of flowering plants consisting of trees, shrubs, or rarely lianas.

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Antiporter

An antiporter (also called exchanger or counter-transporter) is a cotransporter and integral membrane protein involved in secondary active transport of two or more different molecules or ions across a phospholipid membrane such as the plasma membrane in opposite directions.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Asimina triloba

Asimina triloba, the papaw, pawpaw, paw paw, paw-paw, common pawpaw, Quaker delight, or hillbilly mango is a small deciduous tree native to the eastern United States and Canada, producing a large, yellowish-green to brown fruit.

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Bovinae

The biological subfamily Bovinae includes a diverse group of 10 genera of medium to large-sized ungulates, including domestic cattle, bison, African buffalo, the water buffalo, the yak, and the four-horned and spiral-horned antelopes.

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Coenzyme Q – cytochrome c reductase

The coenzyme Q: cytochrome c – oxidoreductase, sometimes called the cytochrome bc1 complex, and at other times complex III, is the third complex in the electron transport chain, playing a critical role in biochemical generation of ATP (oxidative phosphorylation).

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Coenzyme Q10

Coenzyme Q10, also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10, CoQ, or Q10 is a coenzyme that is ubiquitous in animals and most bacteria (hence the name ubiquinone).

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Competitive inhibition

Competitive inhibition is a form of enzyme inhibition where binding of an inhibitor prevents binding of the target molecule of the enzyme, also known as the substrate.

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Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Cytochrome c oxidase

The enzyme cytochrome c oxidase or Complex IV, is a large transmembrane protein complex found in bacteria, archaea, and in eukaryotes in their mitochondria.

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Derris

Derris is genus of leguminous plants found in Southeast Asia and the southwest Pacific islands, including New Guinea.

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Dihydroorotate dehydrogenase

Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16.

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DTNB

Beta dystrobrevin also known as DTNB is a protein which in humans is encoded by the DTNB gene.

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Electrochemical potential

In electrochemistry, the electrochemical potential,, sometimes abbreviated to ECP, is a thermodynamic measure of chemical potential that does not omit the energy contribution of electrostatics.

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Electron

The electron is a subatomic particle, symbol or, whose electric charge is negative one elementary charge.

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Electron paramagnetic resonance

Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials with unpaired electrons.

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Electron transport chain

An electron transport chain (ETC) is a series of complexes that transfer electrons from electron donors to electron acceptors via redox (both reduction and oxidation occurring simultaneously) reactions, and couples this electron transfer with the transfer of protons (H+ ions) across a membrane.

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Electron-transferring flavoprotein

An electron transfer flavoprotein (ETF) or electron transfer flavoprotein complex (CETF) is a flavoprotein located on the matrix face of the inner mitochondrial membrane and functions as a specific electron acceptor for primary dehydrogenases, transferring the electrons to terminal respiratory systems such as electron-transferring-flavoprotein dehydrogenase.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Escherichia coli

Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).

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Fabaceae

The Fabaceae or Leguminosae, Article 18.5 states: "The following names, of long usage, are treated as validly published:....Leguminosae (nom. alt.: Fabaceae; type: Faba Mill.);...

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Faboideae

The Faboideae are a subfamily of the flowering plant family Fabaceae or Leguminosae.

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Flavin adenine dinucleotide

In biochemistry, flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

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Flavin group

Flavin (from Latin flavus, "yellow") is the common name for a group of organic compounds based on pteridine, formed by the tricyclic heterocycle isoalloxazine.

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Flavin mononucleotide

Flavin mononucleotide (FMN), or riboflavin-5′-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors.

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Flutamide

Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer.

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Glycerol-3-phosphate dehydrogenase

Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate (a.k.a. glycerone phosphate, outdated) to sn-glycerol 3-phosphate.

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Heme

Heme or haem is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands.

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

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Human

Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.

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Hydrogen peroxide

Hydrogen peroxide is a chemical compound with the formula.

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Hypoxia (medical)

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.

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Iron–sulfur cluster

Iron–sulfur clusters are molecular ensembles of iron and sulfide.

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Isoflavonoid

Isoflavonoids are a class of flavonoid phenolic compounds, many of which are biologically active.

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Leber's hereditary optic neuropathy

Leber's hereditary optic neuropathy (LHON) or Leber hereditary optic atrophy is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; this affects predominantly young adult males.

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Leigh syndrome

Leigh syndrome (also called Leigh disease and subacute necrotizing encephalomyelopathy) is an under-recognized inherited neurometabolic disorder that affects the central nervous system.

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Loganiaceae

The Loganiaceae are a family of flowering plants classified in order Gentianales.

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Lonchocarpus

Lonchocarpus is a plant genus in the legume family (Fabaceae).

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Malic acid

Malic acid is an organic compound with the molecular formula C4H6O5.

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Mammal

Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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Metformin

Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight.

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Mitochondrial disease

Mitochondrial diseases are a group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for the cell.

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Mitochondrial DNA

Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, adenosine triphosphate (ATP).

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Mrp superfamily

The Na+ Transporting Mrp Superfamily is a superfamily of integral membrane transport proteins.

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MT-ND1

NADH-ubiquinone oxidoreductase chain 1 is a protein that in humans is encoded by the mitochondrial gene MT-ND1.

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MT-ND2

Mitochondrially encoded NADH dehydrogenase 2 is protein that in humans is encoded by the mitochondrial gene MT-ND2 gene.

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MT-ND3

Mitochondrially encoded NADH dehydrogenase 3 is a protein that in humans is encoded by the mitochondrial gene MT-ND3.

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MT-ND4

NADH-ubiquinone oxidoreductase chain 4 is a protein that in humans is encoded by the mitochondrial gene MT-ND4.

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MT-ND4L

NADH-ubiquinone oxidoreductase chain 4L is a protein that in humans is encoded by the mitochondrial gene MT-ND4L.

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MT-ND5

NADH-ubiquinone oxidoreductase chain 5 is a protein that in humans is encoded by the mitochondrial gene MT-ND5.

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MT-ND6

NADH-ubiquinone oxidoreductase chain 6 is a protein that in humans is encoded by the mitochondrial MT-ND6 gene.

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Myocardial infarction

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.

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N-Ethylmaleimide

N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid.

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NADH dehydrogenase (ubiquinone), alpha 1

NADH dehydrogenase 1 alpha subcomplex subunit 1 is a protein that in humans is encoded by the NDUFA1 gene.

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NDUFA10

NADH dehydrogenase 1 alpha subcomplex subunit 10 is an enzyme that in humans is encoded by the NDUFA10 gene.

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NDUFA11

NADH dehydrogenase 1 alpha subcomplex subunit 11 is an enzyme that in humans is encoded by the NDUFA11 gene.

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NDUFA12

NADH dehydrogenase 1 alpha subcomplex subunit 12 is an enzyme that in humans is encoded by the NDUFA12 gene.

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NDUFA13

NADH dehydrogenase 1 alpha subcomplex subunit 13 is an enzyme that in humans is encoded by the NDUFA13 gene.

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NDUFA2

NADH dehydrogenase 1 alpha subcomplex subunit 2 is a protein that in humans is encoded by the NDUFA2 gene.

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NDUFA3

NADH dehydrogenase 1 alpha subcomplex subunit 3 is a protein that in humans is encoded by the NDUFA3 gene.

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NDUFA4

NDUFA4, mitochondrial complex associated is a protein that in humans is encoded by the NDUFA4 gene.

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NDUFA4L2

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 is a protein that in humans is encoded by the NDUFA4L2 gene.

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NDUFA5

NADH dehydrogenase 1 alpha subcomplex subunit 5 is an enzyme that in humans is encoded by the NDUFA5 gene.

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NDUFA6

NADH dehydrogenase 1 alpha subcomplex subunit 6 is an enzyme that in humans is encoded by the NDUFA6 gene.

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NDUFA7

NADH dehydrogenase 1 alpha subcomplex subunit 7 is an enzyme that in humans is encoded by the NDUFA7 gene.

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NDUFA8

NADH dehydrogenase 1 alpha subcomplex subunit 8 is an enzyme that in humans is encoded by the NDUFA8 gene.

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NDUFA9

NADH dehydrogenase 1 alpha subcomplex subunit 9 is an enzyme that in humans is encoded by the NDUFA9 gene.

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NDUFAB1

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa is a protein that in humans is encoded by the NDUFAB1 gene.

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NDUFAF1

Complex I intermediate-associated protein 30, mitochondrial is a protein that in humans is encoded by the NDUFAF1 gene.

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NDUFB1

NADH dehydrogenase 1 beta subcomplex subunit 1 is an enzyme that in humans is encoded by the NDUFB1 gene.

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NDUFB10

NADH dehydrogenase 1 beta subcomplex subunit 10 is an enzyme that in humans is encoded by the NDUFB10 gene.

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NDUFB11

NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NADH-ubiquinone oxidoreductase ESSS subunit) is an enzyme that in humans is encoded by the NDUFB11 gene.

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NDUFB2

NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial is an enzyme that in humans is encoded by the NDUFB2 gene.

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NDUFB3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa is a protein that in humans is encoded by the NDUFB3 gene.

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NDUFB4

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa is a protein that in humans is encoded by the NDUFB4 gene.

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NDUFB5

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa is a protein that in humans is encoded by the NDUFB5 gene.

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NDUFB6

NADH dehydrogenase 1 beta subcomplex subunit 6, also known as complex I-B17, is a protein that in humans is encoded by the NDUFB6 gene.

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NDUFB7

NADH dehydrogenase 1 beta subcomplex subunit 7, also known as complex I-B18, is an enzyme that in humans is encoded by the NDUFB7 gene.

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NDUFB8

NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial is an enzyme that in humans is encoded by the NDUFB8 gene.

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NDUFB9

NADH dehydrogenase 1 beta subcomplex subunit 9 is an enzyme that in humans is encoded by the NDUFB9 gene.

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NDUFC1

NADH dehydrogenase 1 subunit C1, mitochondrial is an enzyme that in humans is encoded by the NDUFC1 gene.

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NDUFC2

NADH dehydrogenase 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene.

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NDUFS1

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial is an enzyme that in humans is encoded by the NDUFS1 gene.

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NDUFS2

NADH dehydrogenase iron-sulfur protein 2, mitochondrial also known as NADH-ubiquinone oxidoreductase 49 kDa subunit is an enzyme that in humans is encoded by the NDUFS2 gene.

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NDUFS3

NADH dehydrogenase iron-sulfur protein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFS3 gene on chromosome 11.

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NDUFS4

NADH dehydrogenase iron-sulfur protein 4, mitochondrial also known as NADH-ubiquinone oxidoreductase 18 kDa subunit is an enzyme that in humans is encoded by the NDUFS4 gene.

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NDUFS5

NADH dehydrogenase iron-sulfur protein 5 is an enzyme that in humans is encoded by the NDUFS5 gene.

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NDUFS6

NADH dehydrogenase iron-sulfur protein 6, mitochondrial is an enzyme that in humans is encoded by the NDUFS6 gene.

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NDUFS7

NADH dehydrogenase iron-sulfur protein 7, mitochondrial, also knowns as NADH-ubiquinone oxidoreductase 20 kDa subunit, is an enzyme that in humans is encoded by the NDUFS7 gene.

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NDUFS8

NADH dehydrogenase iron-sulfur protein 8, mitochondrial also known as NADH-ubiquinone oxidoreductase 23 kDa subunit is an enzyme that in humans is encoded by the NDUFS8 gene.

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NDUFV1

NADH dehydrogenase flavoprotein 1, mitochondrial is an enzyme that in humans is encoded by the NDUFV1 gene.

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NDUFV2

NADH dehydrogenase flavoprotein 2, mitochondrial is an enzyme that in humans is encoded by the NDUFV2 gene.

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NDUFV3

NADH dehydrogenase flavoprotein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFV3 gene.

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Nefazodone

Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant which was first marketed by Bristol-Myers Squibb in 1994 but has since largely been discontinued.

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Nicotinamide adenine dinucleotide

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.

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Nitric oxide

Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.

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Oxaloacetic acid

Oxaloacetic acid (also known as oxalacetic acid) is a crystalline organic compound with the chemical formula HO2CC(O)CH2CO2H.

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Paracoccus denitrificans

Paracoccus denitrificans, is a coccoid bacterium known for its nitrate reducing properties, its ability to replicate under conditions of hypergravity and for being a relative of the eukaryotic mitochondrion (endosymbiotic theory).

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Peroxynitrite

Peroxynitrite (sometimes called peroxonitrite) is an ion with the formula ONOO−.

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Pfam

Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models.

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Piericidin A

Piericidin A is an antibiotic agent.

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Programmed cell death

Programmed cell death (or PCD) is the death of a cell in any form, mediated by an intracellular program.

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Proton pump

A proton pump is an integral membrane protein that builds up a proton gradient across a biological membrane.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Reperfusion injury

Reperfusion injury or reperfusion insult, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).

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Rhodothermus marinus

Rhodothermus marinus is a species of bacteria.

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Rotenone

Rotenone is an odorless, colorless, crystalline isoflavone used as a broad-spectrum insecticide, piscicide, and pesticide.

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Schizosaccharomyces pombe

Schizosaccharomyces pombe, also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology.

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Semiquinone

Semiquinone (or ubisemiquinone) is a free radical resulting from the removal of one hydrogen atom with its electron during the process of dehydrogenation of a hydroquinone, such as hydroquinone itself or catechol, to a quinone or alternatively the addition of a single H atom to a quinone.

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Stroke

A stroke is a medical condition in which poor blood flow to the brain results in cell death.

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Succinate dehydrogenase

Succinate dehydrogenase (SDH) or succinate-coenzyme Q reductase (SQR) or respiratory Complex II is an enzyme complex, found in many bacterial cells and in the inner mitochondrial membrane of eukaryotes.

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Succinic acid

Succinic acid is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2.

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Superoxide

A superoxide is a compound that contains the superoxide anion, which has the chemical formula.

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Ubiquinol

Ubiquinol is an electron-rich (reduced) form of coenzyme Q10.

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UniProt

UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects.

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Water potential

Water potential is the potential energy of water per unit volume relative to pure water in reference conditions.

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Redirects here:

Complex I, EC 1.6.5.3, Mitochondrial complex I, NADH dehydrogenase (ubiquinone), NADH:ubiquinone reductase, NADH:ubiquinone reductase (H+-translocating), Nadh dehydrogenase.

References

[1] https://en.wikipedia.org/wiki/NADH:ubiquinone_oxidoreductase_(H%2B-translocating)

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