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Tesofensine

Index Tesofensine

Tesofensine (NS2330) is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is being developed for the treatment of obesity. [1]

21 relations: Alzheimer's disease, Anorectic, Antidepressant, Brain-derived neurotrophic factor, Cholinergic, Cognition, CYP3A4, Dopamine transporter, Food and Drug Administration, IC50, List of Latin phrases (I), Neurotransmission, Norepinephrine transporter, Obesity, Open-label trial, Overweight, Parkinson's disease, Phenyltropane, Placebo-controlled study, Serotonin transporter, Serotonin–norepinephrine–dopamine reuptake inhibitor.

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Anorectic

An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss.

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Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Brain-derived neurotrophic factor

Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene.

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Cholinergic

In general, the word choline refers to the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation.

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Cognition

Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

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CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.

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Dopamine transporter

The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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IC50

The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.

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List of Latin phrases (I)

Additional sources.

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Neurotransmission

Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).

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Norepinephrine transporter

The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.

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Obesity

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Open-label trial

An open-label trial, or open trial, is a type of clinical trial in which both the researchers and participants know which treatment is being administered.

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Overweight

Being overweight or fat is having more body fat than is optimally healthy.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Phenyltropane

Phenyltropanes (PTs) were originally developed to reduce cocaine addiction and dependency.

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Placebo-controlled study

Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham "placebo" treatment which is specifically designed to have no real effect.

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Serotonin transporter

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.

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Serotonin–norepinephrine–dopamine reuptake inhibitor

A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine.

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Redirects here:

C17H23Cl2NO, NS-2330, NS2330.

References

[1] https://en.wikipedia.org/wiki/Tesofensine

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