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Nearly neutral theory of molecular evolution

Index Nearly neutral theory of molecular evolution

The nearly neutral theory of molecular evolution is a modification of the neutral theory of molecular evolution that accounts for the fact that not all mutations are either so deleterious such that they can be ignored, or else neutral. [1]

15 relations: Amino acid, DNA sequencing, Effective population size, Fixation (population genetics), Generation time, Genetic drift, Genetic load, History of molecular evolution, Michael Lynch (geneticist), Molecular phylogenetics, Mutation, Neutral theory of molecular evolution, Non-coding DNA, Selection coefficient, Tomoko Ohta.

Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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DNA sequencing

DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule.

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Effective population size

The effective population size is "the number of individuals in a population who contribute offspring to the next generation," or all the breeding adults in that population.

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Fixation (population genetics)

In population genetics, fixation is the change in a gene pool from a situation where there exists at least two variants of a particular gene (allele) in a given population to a situation where only one of the alleles remains.

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Generation time

In population biology and demography, the generation time is the average time between two consecutive generations in the lineages of a population.

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Genetic drift

Genetic drift (also known as allelic drift or the Sewall Wright effect) is the change in the frequency of an existing gene variant (allele) in a population due to random sampling of organisms.

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Genetic load

Genetic load is the difference between the fitness of an average genotype in a population and the fitness of some reference genotype, which may be either the best present in a population, or may be the theoretically optimal genotype.

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History of molecular evolution

The history of molecular evolution starts in the early 20th century with "comparative biochemistry", but the field of molecular evolution came into its own in the 1960s and 1970s, following the rise of molecular biology.

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Michael Lynch (geneticist)

Michael Lynch (born 1951) is the Director of the Biodesign Institute for Mechanisms of Evolution at Arizona State University, Tempe, Arizona.

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Molecular phylogenetics

Molecular phylogenetics is the branch of phylogeny that analyzes genetic, hereditary molecular differences, predominately in DNA sequences, to gain information on an organism's evolutionary relationships.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Neutral theory of molecular evolution

The neutral theory of molecular evolution holds that at the molecular level most evolutionary changes and most of the variation within and between species is not caused by natural selection but by genetic drift of mutant alleles that are neutral.

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Non-coding DNA

In genomics and related disciplines, noncoding DNA sequences are components of an organism's DNA that do not encode protein sequences.

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Selection coefficient

In population genetics, a selection coefficient, usually denoted by the letter s, is a measure of differences in fitness.

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Tomoko Ohta

is a Japanese scientist working on population genetics/molecular evolution.

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Near neutrality, Near-neutrality, Nearly neutral, Nearly neutral theory, Nearly neutral theory of evolution.

References

[1] https://en.wikipedia.org/wiki/Nearly_neutral_theory_of_molecular_evolution

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