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Neurotoxicity

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Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. [1]

57 relations: Alzheimer's disease, Amyloid beta, Apoptosis, Batrachotoxin, Bcl-2, Bcl-2-associated death promoter, Brain damage, C-Jun N-terminal kinases, Central nervous system, Chemotherapy, Classical compound, Clearance (pharmacology), Cytotoxicity, Dopamine, Excitotoxicity, Extracellular signal–regulated kinases, G0 phase, Glutamate receptor, Glutamate transporter, Glutamic acid, Heavy metals, Hydrogen peroxide, Hydroxy group, Mitochondrion, Mitogen-activated protein kinase, Multiple chemical sensitivity, N-Methyl-D-aspartic acid, Nephrotoxicity, Nervous system, Nervous tissue, Neurocognitive, Neurodegeneration, Neuron, Neurotoxin, Neurotransmission, Nicotine, Nicotinic acetylcholine receptor, Nitric oxide, Nitric oxide synthase, Organ transplantation, Ototoxicity, Oxidative phosphorylation, Oxidative stress, Penitrem A, Peripheral nervous system, Pesticide, Pharmacotherapy, Protein kinase B, Radiation therapy, Radical (chemistry), ..., Reactive oxygen species, Recreational drug use, Senile plaques, Solvent, Superoxide, Tetrahydrobiopterin, Toxicity. Expand index (7 more) »

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Amyloid beta

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Batrachotoxin

Batrachotoxin (BTX) is an extremely potent cardiotoxic and neurotoxic steroidal alkaloid found in certain species of frogs (poison dart frog), melyrid beetles, and birds (the pitohui, blue-capped ifrit, and little shrikethrush).

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Bcl-2

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.

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Bcl-2-associated death promoter

The Bcl-2-associated death promoter (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis.

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Brain damage

Brain damage or brain injury (BI) is the destruction or degeneration of brain cells.

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C-Jun N-terminal kinases

c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Christmas

Christmas is an annual festival commemorating the birth of Jesus Christ,Martindale, Cyril Charles.

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Christmas and holiday season

The Christmas season, also called the festive season, or the holiday season (mainly in the U.S. and Canada; often simply called the holidays),, is an annually recurring period recognized in many Western and Western-influenced countries that is generally considered to run from late November to early January.

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Christmas Eve

Christmas Eve is the evening or entire day before Christmas Day, the festival commemorating the birth of Jesus.

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Christmas traditions

Christmas traditions vary from country to country.

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Classical compound

Classical compounds and neoclassical compounds are compound words composed from combining forms (which act as affixes or stems) derived from classical Latin or ancient Greek roots.

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Clearance (pharmacology)

In pharmacology, the clearance is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time; the usual units are mL/min.

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Cytotoxicity

Cytotoxicity is the quality of being toxic to cells.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Excitotoxicity

Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.

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Extracellular signal–regulated kinases

In molecular biology, extracellular signal–regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.

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G0 phase

The G0 phase describes a cellular state outside of the replicative cell cycle.

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Glutamate receptor

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.

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Glutamate transporter

Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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Heavy metals

Heavy metals are generally defined as metals with relatively high densities, atomic weights, or atomic numbers.

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Hydrogen peroxide

Hydrogen peroxide is a chemical compound with the formula.

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Hydroxy group

A hydroxy or hydroxyl group is the entity with the formula OH.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Mitogen-activated protein kinase

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).

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Multiple chemical sensitivity

Multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI), is a disputed chronic condition characterized by symptoms that the affected person attributes to low-level exposures to commonly used chemicals.

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N-Methyl-D-aspartic acid

N-Methyl-D-aspartic acid or N-Methyl-D-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

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Nephrotoxicity

Nephrotoxicity is toxicity in the kidneys.

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Nervous system

The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body.

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Nervous tissue

Nervous tissue or nerve tissue is the main tissue component of the two parts of the nervous system; the brain and spinal cord of the central nervous system (CNS), and the branching peripheral nerves of the peripheral nervous system (PNS), which regulates and controls bodily functions and activity.

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Neurocognitive

Neurocognitive functions are cognitive functions closely linked to the function of particular areas, neural pathways, or cortical networks in the brain substrate layers of neurological matrix at the cellular molecular level.

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Neurodegeneration

Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.

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Neuron

A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

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Neurotoxin

Neurotoxins are toxins that are poisonous or destructive to nerve tissue (causing neurotoxicity).

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Neurotransmission

Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).

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New Year

New Year is the time or day at which a new calendar year begins and the calendar's year count increments by one.

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New Year's Day

New Year's Day, also called simply New Year's or New Year, is observed on January 1, the first day of the year on the modern Gregorian calendar as well as the Julian calendar.

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New Year's Eve

In the Gregorian calendar, New Year's Eve (also known as Old Year's Day or Saint Sylvester's Day in many countries), the last day of the year, is on 31 December which is the seventh day of Christmastide.

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Nicotine

Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants.

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Nicotinic acetylcholine receptor

Nicotinic acetylcholine receptors, or nAChRs, are receptor proteins that respond to the neurotransmitter acetylcholine.

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Nitric oxide

Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.

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Nitric oxide synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.

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Organ transplantation

Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ.

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Ototoxicity

Ototoxicity is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug.

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Oxidative phosphorylation

Oxidative phosphorylation (or OXPHOS in short) (UK, US) is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing energy which is used to produce adenosine triphosphate (ATP).

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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Penitrem A

Penitrem A (tremortin) is an indol-diterpenoid mycotoxin produced by certain species of Aspergillus, ''Claviceps'', and Penicillium, which can be found growing on various plant species such as ryegrass.

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Peripheral nervous system

The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).

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Pesticide

Pesticides are substances that are meant to control pests, including weeds.

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Pharmacotherapy

Pharmacotherapy is therapy using pharmaceutical drugs, as distinguished from therapy using surgery (surgical therapy), radiation (radiation therapy), movement (physical therapy), or other modes.

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Protein kinase B

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.

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Radiation therapy

Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator.

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Radical (chemistry)

In chemistry, a radical (more precisely, a free radical) is an atom, molecule, or ion that has an unpaired valence electron.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Recreational drug use

Recreational drug use is the use of a psychoactive drug to induce an altered state of consciousness for pleasure, by modifying the perceptions, feelings, and emotions of the user.

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Senile plaques

Senile plaques (also known as neuritic plaques) are extracellular deposits of amyloid beta in the grey matter of the brain.

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Solvent

A solvent (from the Latin solvō, "loosen, untie, solve") is a substance that dissolves a solute (a chemically distinct liquid, solid or gas), resulting in a solution.

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Superoxide

A superoxide is a compound that contains the superoxide anion, which has the chemical formula.

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Tetrahydrobiopterin

Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases.

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Toxicity

Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.

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2018

2018 has been designated as the third International Year of the Reef by the International Coral Reef Initiative.

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2019

2019 (MMXIX) will be a common year starting on Tuesday of the Gregorian calendar, the 2019th year of the Common Era (CE) and Anno Domini (AD) designations, the 19th year of the 3rd millennium, the 19th year of the 21st century, and the 10th and last year of the 2010s decade.

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Glial cell toxicity, Neurotoxic, Neurotoxicant, Neurotoxicity syndromes.

References

[1] https://en.wikipedia.org/wiki/Neurotoxicity

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