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Nonsteroidal antiandrogen

Index Nonsteroidal antiandrogen

A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure. [1]

Table of Contents

  1. 86 relations: Acne, Alcohol intolerance, Androgen, Androgen receptor, Androgen synthesis inhibitor, Androgen-dependent condition, Antiandrogen, Antigonadotropin, Anxiety, Apalutamide, Benign prostatic hyperplasia, Bicalutamide, Binding selectivity, Biological half-life, Biological target, Central nervous system, Chemical structure, Cimetidine, Cioteronel, Clinical trial, Congenital adrenal hyperplasia, Cytochrome P450, Czech Republic, Darolutamide, Dihydrotestosterone, Discovery and development of antiandrogens, Distribution (pharmacology), Drug interaction, Efficacy, Elevated transaminases, Enzalutamide, Enzyme, Enzyme inducer, Enzyme inhibitor, Estradiol, Feminizing hormone therapy, Flutamide, GABAA receptor, Generic drug, Glucocorticoid, Gynecomastia, H2 receptor antagonist, Hepatotoxicity, Hirsutism, Histamine, Hyperandrogenism, Inocoterone acetate, Insomnia, Interstitial lung disease, Ketoconazole, ... Expand index (36 more) »

  2. Antiandrogens
  3. Hair loss medications
  4. Hair removal
  5. Sex hormones

Acne

Acne, also known as acne vulgaris, is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles.

See Nonsteroidal antiandrogen and Acne

Alcohol intolerance

Alcohol intolerance is due to a genetic polymorphism of the aldehyde dehydrogenase enzyme, which is responsible for the metabolism of acetaldehyde (produced from the metabolism of alcohol by alcohol dehydrogenase).

See Nonsteroidal antiandrogen and Alcohol intolerance

Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. Nonsteroidal antiandrogen and androgen are sex hormones.

See Nonsteroidal antiandrogen and Androgen

Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus.

See Nonsteroidal antiandrogen and Androgen receptor

Androgen synthesis inhibitor

An androgen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of androgens, such as testosterone and dihydrotestosterone (DHT).

See Nonsteroidal antiandrogen and Androgen synthesis inhibitor

Androgen-dependent condition

An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body.

See Nonsteroidal antiandrogen and Androgen-dependent condition

Antiandrogen

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. Nonsteroidal antiandrogen and Antiandrogen are anti-acne preparations, antiandrogens, hair loss medications, hair removal, Hormonal antineoplastic drugs and sex hormones.

See Nonsteroidal antiandrogen and Antiandrogen

Antigonadotropin

An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

See Nonsteroidal antiandrogen and Antigonadotropin

Anxiety

Anxiety is an emotion which is characterised by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events.

See Nonsteroidal antiandrogen and Anxiety

Apalutamide

Apalutamide, sold under the brand name Erleada among others, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer. Nonsteroidal antiandrogen and Apalutamide are Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Apalutamide

Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland.

See Nonsteroidal antiandrogen and Benign prostatic hyperplasia

Bicalutamide

Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer. Nonsteroidal antiandrogen and Bicalutamide are anti-acne preparations, antiandrogens, hair loss medications, hair removal, Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Bicalutamide

Binding selectivity

In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

See Nonsteroidal antiandrogen and Binding selectivity

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Nonsteroidal antiandrogen and Biological half-life

Biological target

A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.

See Nonsteroidal antiandrogen and Biological target

Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.

See Nonsteroidal antiandrogen and Central nervous system

Chemical structure

A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds.

See Nonsteroidal antiandrogen and Chemical structure

Cimetidine

Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production. Nonsteroidal antiandrogen and Cimetidine are nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Cimetidine

Cioteronel

Cioteronel (developmental code name CPC-10997; former tentative brand names Cyoctol, X-Andron) is a nonsteroidal antiandrogen (NSAA) that was never marketed. Nonsteroidal antiandrogen and Cioteronel are anti-acne preparations and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Cioteronel

Clinical trial

Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison.

See Nonsteroidal antiandrogen and Clinical trial

Congenital adrenal hyperplasia

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis.

See Nonsteroidal antiandrogen and Congenital adrenal hyperplasia

Cytochrome P450

Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.

See Nonsteroidal antiandrogen and Cytochrome P450

Czech Republic

The Czech Republic, also known as Czechia, is a landlocked country in Central Europe.

See Nonsteroidal antiandrogen and Czech Republic

Darolutamide

Darolutamide, sold under the brand name Nubeqa, is an antiandrogen medication which is used in the treatment of non-metastatic castration-resistant prostate cancer in men. Nonsteroidal antiandrogen and Darolutamide are Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Darolutamide

Dihydrotestosterone

Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition. Nonsteroidal antiandrogen and Dihydrotestosterone are sex hormones.

See Nonsteroidal antiandrogen and Dihydrotestosterone

Discovery and development of antiandrogens

The first antiandrogen was discovered in the 1960s. Nonsteroidal antiandrogen and discovery and development of antiandrogens are antiandrogens.

See Nonsteroidal antiandrogen and Discovery and development of antiandrogens

Distribution (pharmacology)

Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.

See Nonsteroidal antiandrogen and Distribution (pharmacology)

Drug interaction

In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs.

See Nonsteroidal antiandrogen and Drug interaction

Efficacy

Efficacy is the ability to perform a task to a satisfactory or expected degree.

See Nonsteroidal antiandrogen and Efficacy

Elevated transaminases

In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver dysfunction.

See Nonsteroidal antiandrogen and Elevated transaminases

Enzalutamide

Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer. Nonsteroidal antiandrogen and Enzalutamide are Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Enzalutamide

Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

See Nonsteroidal antiandrogen and Enzyme

Enzyme inducer

An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme.

See Nonsteroidal antiandrogen and Enzyme inducer

Enzyme inhibitor

An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.

See Nonsteroidal antiandrogen and Enzyme inhibitor

Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. Nonsteroidal antiandrogen and Estradiol are sex hormones.

See Nonsteroidal antiandrogen and Estradiol

Feminizing hormone therapy

Feminizing hormone therapy, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to change the secondary sex characteristics of transgender people from masculine or androgynous to feminine.

See Nonsteroidal antiandrogen and Feminizing hormone therapy

Flutamide

Flutamide, sold under the brand name Eulexin among others, is a nonsteroidal antiandrogen (NSAA) which is used primarily to treat prostate cancer. Nonsteroidal antiandrogen and Flutamide are anti-acne preparations, hair loss medications, hair removal, Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Flutamide

GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

See Nonsteroidal antiandrogen and GABAA receptor

Generic drug

A generic drug (or simply generic) is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents.

See Nonsteroidal antiandrogen and Generic drug

Glucocorticoid

Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.

See Nonsteroidal antiandrogen and Glucocorticoid

Gynecomastia

Gynecomastia (also spelled gynaecomastia) is the abnormal non-cancerous enlargement of one or both breasts in males due to the growth of breast tissue as a result of a hormone imbalance between estrogens and androgens.

See Nonsteroidal antiandrogen and Gynecomastia

H2 receptor antagonist

H2 antagonists, sometimes referred to as H2RAs and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the stomach.

See Nonsteroidal antiandrogen and H2 receptor antagonist

Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

See Nonsteroidal antiandrogen and Hepatotoxicity

Hirsutism

Hirsutism is excessive body hair on parts of the body where hair is normally absent or minimal.

See Nonsteroidal antiandrogen and Hirsutism

Histamine

Histamine is an organic nitrogenous compound involved in local immune responses communication, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.

See Nonsteroidal antiandrogen and Histamine

Hyperandrogenism

Hyperandrogenism is a medical condition characterized by high levels of androgens.

See Nonsteroidal antiandrogen and Hyperandrogenism

Inocoterone acetate

Inocoterone acetate (developmental code names RU-38882, RU-882) is a steroid-like nonsteroidal antiandrogen (NSAA) that was developed for topical administration to treat acne but was never marketed. Nonsteroidal antiandrogen and Inocoterone acetate are anti-acne preparations and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Inocoterone acetate

Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

See Nonsteroidal antiandrogen and Insomnia

Interstitial lung disease

Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of respiratory diseases affecting the interstitium (the tissue) and space around the alveoli (air sacs) of the lungs.

See Nonsteroidal antiandrogen and Interstitial lung disease

Ketoconazole

Ketoconazole, sold under the brand name Nizoral among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. Nonsteroidal antiandrogen and Ketoconazole are hair loss medications, Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Ketoconazole

Metabolism

Metabolism (from μεταβολή metabolÄ“, "change") is the set of life-sustaining chemical reactions in organisms.

See Nonsteroidal antiandrogen and Metabolism

Mineralocorticoid receptor antagonist

A mineralocorticoid receptor antagonist (MRA or MCRA) or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors.

See Nonsteroidal antiandrogen and Mineralocorticoid receptor antagonist

Mutation

In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA.

See Nonsteroidal antiandrogen and Mutation

N-Terminal domain antiandrogen

N-Terminal domain antiandrogens are a novel type of antiandrogen that bind to the ''N''-terminal domain of the androgen receptor (AR) instead of the ligand-binding domain (where all currently-available antiandrogens bind) and disrupt interactions between the AR and its coregulatory binding partners, thereby blocking AR-mediated gene transcription. Nonsteroidal antiandrogen and n-Terminal domain antiandrogen are antiandrogens.

See Nonsteroidal antiandrogen and N-Terminal domain antiandrogen

Nausea

Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit.

See Nonsteroidal antiandrogen and Nausea

Nilutamide

Nilutamide, sold under the brand names Nilandron and Anandron, is a nonsteroidal antiandrogen (NSAA) which is used in the treatment of prostate cancer. Nonsteroidal antiandrogen and Nilutamide are Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Nilutamide

Nonsteroidal

A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative.

See Nonsteroidal antiandrogen and Nonsteroidal

Nonsteroidal estrogen

A nonsteroidal estrogen is an estrogen with a nonsteroidal chemical structure. Nonsteroidal antiandrogen and nonsteroidal estrogen are sex hormones.

See Nonsteroidal antiandrogen and Nonsteroidal estrogen

Over-the-counter drug

Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescription.

See Nonsteroidal antiandrogen and Over-the-counter drug

Patent

A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention.

See Nonsteroidal antiandrogen and Patent

Pattern hair loss

Pattern hair loss (also known as androgenetic alopecia (AGA)) is a hair loss condition that primarily affects the top and front of the scalp.

See Nonsteroidal antiandrogen and Pattern hair loss

Pharmacovigilance

Pharmacovigilance (PV, or PhV), also known as drug safety, is the pharmaceutical science relating to the "collection, detection, assessment, monitoring, and prevention" of adverse effects with pharmaceutical products.

See Nonsteroidal antiandrogen and Pharmacovigilance

Polycystic ovary syndrome

Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age.

See Nonsteroidal antiandrogen and Polycystic ovary syndrome

Potency (pharmacology)

In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.

See Nonsteroidal antiandrogen and Potency (pharmacology)

Precocious puberty

In medicine, precocious puberty is puberty occurring at an unusually early age.

See Nonsteroidal antiandrogen and Precocious puberty

Priapism

Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after stimulation has ended.

See Nonsteroidal antiandrogen and Priapism

Progestogen

Progestogens, also sometimes written progestins, progestagens or gestagens, are a class of natural or synthetic steroid hormones that bind to and activate the progesterone receptors (PR). Nonsteroidal antiandrogen and Progestogen are sex hormones.

See Nonsteroidal antiandrogen and Progestogen

Prostate cancer

Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.

See Nonsteroidal antiandrogen and Prostate cancer

Proxalutamide

Proxalutamide (developmental code name GT-0918) is a nonsteroidal antiandrogen (NSAA) – specifically, a selective high-affinity silent antagonist of the androgen receptor (AR) – which is under development by Suzhou Kintor Pharmaceuticals, inc., a subsidiary of Kintor Pharmaceutical Limited, for the potential treatment of COVID-19, prostate cancer, and breast cancer. Nonsteroidal antiandrogen and Proxalutamide are Hormonal antineoplastic drugs and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Proxalutamide

Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

See Nonsteroidal antiandrogen and Receptor antagonist

RU-58841

RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA) which was initially developed in the 1980s by Roussel Uclaf, the French pharmaceutical company from which it received its name. Nonsteroidal antiandrogen and rU-58841 are anti-acne preparations, hair loss medications, hair removal and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and RU-58841

Sebaceous gland

A sebaceous gland or oil gland is a microscopic exocrine gland in the skin that opens into a hair follicle to secrete an oily or waxy matter, called sebum, which lubricates the hair and skin of mammals.

See Nonsteroidal antiandrogen and Sebaceous gland

Seizure

A seizure is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

See Nonsteroidal antiandrogen and Seizure

Selective androgen receptor modulator

Selective androgen receptor modulators (SARMs) are a class of drugs that selectively activate the androgen receptor in specific tissues, promoting muscle and bone growth while having less effect on male reproductive tissues like the prostate gland.

See Nonsteroidal antiandrogen and Selective androgen receptor modulator

Seviteronel

Seviteronel (developmental codes VT-464 and, formerly, INO-464) is an experimental cancer medication which is under development by Viamet Pharmaceuticals and Innocrin Pharmaceuticals for the treatment of prostate cancer and breast cancer. Nonsteroidal antiandrogen and Seviteronel are nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Seviteronel

Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is unintended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

See Nonsteroidal antiandrogen and Side effect

Skin condition

A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands.

See Nonsteroidal antiandrogen and Skin condition

Slovakia

Slovakia (Slovensko), officially the Slovak Republic (Slovenská republika), is a landlocked country in Central Europe.

See Nonsteroidal antiandrogen and Slovakia

Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

See Nonsteroidal antiandrogen and Steroid

Steroidal antiandrogen

A steroidal antiandrogen (SAA) is an antiandrogen with a steroidal chemical structure. Nonsteroidal antiandrogen and steroidal antiandrogen are anti-acne preparations, antiandrogens, hair loss medications, hair removal, Hormonal antineoplastic drugs and sex hormones.

See Nonsteroidal antiandrogen and Steroidal antiandrogen

Testosterone

Testosterone is the primary male sex hormone and androgen in males. Nonsteroidal antiandrogen and Testosterone are sex hormones.

See Nonsteroidal antiandrogen and Testosterone

Topical medication

A topical medication is a medication that is applied to a particular place on or in the body.

See Nonsteroidal antiandrogen and Topical medication

Topilutamide

Topilutamide, known more commonly as fluridil and sold under the brand name Eucapil, is an antiandrogen medication which is used in the treatment of pattern hair loss in men and women. Nonsteroidal antiandrogen and Topilutamide are hair loss medications and nonsteroidal antiandrogens.

See Nonsteroidal antiandrogen and Topilutamide

Trans woman

A trans woman (short for transgender woman) is a woman who was assigned male at birth.

See Nonsteroidal antiandrogen and Trans woman

Vision disorder

A vision disorder is an impairment of the sense of vision.

See Nonsteroidal antiandrogen and Vision disorder

Vomiting

Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.

See Nonsteroidal antiandrogen and Vomiting

See also

Antiandrogens

Hair loss medications

Hair removal

Sex hormones

References

[1] https://en.wikipedia.org/wiki/Nonsteroidal_antiandrogen

Also known as First-generation NSAA, First-generation NSAAs, First-generation nonsteroidal antiandrogen, First-generation nonsteroidal antiandrogens, NSAAs, Non-steroid anti-androgen, Non-steroid anti-androgens, Non-steroid antiandrogen, Non-steroid antiandrogens, Non-steroidal Antiandrogen, Non-steroidal Antiandrogens, Non-steroidal androgen receptor antagonist, Non-steroidal androgen receptor antagonists, Non-steroidal anti-androgen, Non-steroidal anti-androgens, Nonsteroid anti-androgen, Nonsteroid anti-androgens, Nonsteroid antiandrogen, Nonsteroid antiandrogens, Nonsteroidal Antiandrogens, Nonsteroidal androgen receptor antagonist, Nonsteroidal androgen receptor antagonists, Nonsteroidal anti-androgen, Nonsteroidal anti-androgens, Second-generation NSAA, Second-generation NSAAs, Second-generation nonsteroidal antiandrogen, Second-generation nonsteroidal antiandrogens.

, Metabolism, Mineralocorticoid receptor antagonist, Mutation, N-Terminal domain antiandrogen, Nausea, Nilutamide, Nonsteroidal, Nonsteroidal estrogen, Over-the-counter drug, Patent, Pattern hair loss, Pharmacovigilance, Polycystic ovary syndrome, Potency (pharmacology), Precocious puberty, Priapism, Progestogen, Prostate cancer, Proxalutamide, Receptor antagonist, RU-58841, Sebaceous gland, Seizure, Selective androgen receptor modulator, Seviteronel, Side effect, Skin condition, Slovakia, Steroid, Steroidal antiandrogen, Testosterone, Topical medication, Topilutamide, Trans woman, Vision disorder, Vomiting.