Norbuprenorphine-3-glucuronide

Norbuprenorphine-3-glucuronide (N3G) is a major active metabolite of the opioid modulator buprenorphine. ^[1]

19 relations: Active metabolite, Agonist, Analgesic, Animal locomotion, Blood–brain barrier, Buprenorphine, Buprenorphine-3-glucuronide, Hydrophile, Ligand (biochemistry), Morphine-3-glucuronide, Nociceptin receptor, Norbuprenorphine, Opioid modulator, P-glycoprotein, Receptor antagonist, Respiratory rate, Sedation, Substrate (chemistry), Tidal volume.
Glucuronide esters
Opioid metabolites

Active metabolite

An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical.

See Norbuprenorphine-3-glucuronide and Active metabolite

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

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Analgesic

An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.

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Animal locomotion

In ethology, animal locomotion is any of a variety of methods that animals use to move from one place to another.

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The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.

See Norbuprenorphine-3-glucuronide and Blood–brain barrier

Buprenorphine

Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. Norbuprenorphine-3-glucuronide and Buprenorphine are Ethers, Phenols and Tertiary alcohols.

See Norbuprenorphine-3-glucuronide and Buprenorphine

Buprenorphine-3-glucuronide

Buprenorphine-3-glucuronide (B3G) is a major active metabolite of the opioid modulator buprenorphine. Norbuprenorphine-3-glucuronide and buprenorphine-3-glucuronide are Glucuronide esters, human drug metabolites, opioid metabolites and Tertiary alcohols.

See Norbuprenorphine-3-glucuronide and Buprenorphine-3-glucuronide

Hydrophile

A hydrophile is a molecule or other molecular entity that is attracted to water molecules and tends to be dissolved by water.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Morphine-3-glucuronide

Morphine-3-glucuronide is a metabolite of morphine produced by UGT2B7. Norbuprenorphine-3-glucuronide and morphine-3-glucuronide are Glucuronide esters, opioid metabolites and Peripherally selective drugs.

See Norbuprenorphine-3-glucuronide and Morphine-3-glucuronide

Nociceptin receptor

The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene.

See Norbuprenorphine-3-glucuronide and Nociceptin receptor

Norbuprenorphine

Norbuprenorphine is a major active metabolite of the opioid modulator buprenorphine. Norbuprenorphine-3-glucuronide and Norbuprenorphine are Ethers, human drug metabolites, kappa-opioid receptor agonists, nervous system drug stubs, opioid metabolites, Peripherally selective drugs, Phenols and Tertiary alcohols.

See Norbuprenorphine-3-glucuronide and Norbuprenorphine

Opioid modulator

An opioid modulator (or opioid receptor modulator) is a drug which has mixed agonist and antagonist actions at different opioid receptors and thus cannot clearly be described as either an opioid agonist or antagonist.

See Norbuprenorphine-3-glucuronide and Opioid modulator

P-glycoprotein

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

See Norbuprenorphine-3-glucuronide and Receptor antagonist

Respiratory rate

The respiratory rate is the rate at which breathing occurs; it is set and controlled by the respiratory center of the brain.

See Norbuprenorphine-3-glucuronide and Respiratory rate

Sedation

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

See Norbuprenorphine-3-glucuronide and Sedation

Substrate (chemistry)

In chemistry, the term substrate is highly context-dependent.

See Norbuprenorphine-3-glucuronide and Substrate (chemistry)

Tidal volume

Tidal volume (symbol VT or TV) is the volume of air inspired and expired with each passive breath.

See Norbuprenorphine-3-glucuronide and Tidal volume

References

[1] https://en.wikipedia.org/wiki/Norbuprenorphine-3-glucuronide

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