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Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter. [1]

185 relations: Abdomen, Acetylcholine, Action potential, Adenylyl cyclase, Adipose tissue, Adrenal gland, Adrenal medulla, Adrenaline, Adrenergic receptor, Alcohol dependence, Alpha blocker, Alpha-1 adrenergic receptor, Alpha-1 blocker, Alpha-2 adrenergic receptor, Alpha-2 blocker, Amino acid, Amphetamine, Angina, Antidepressant, Antipsychotic, Aromatic L-amino acid decarboxylase, Arousal, Artery, Arturo Rosenblueth, Atomoxetine, Atrial fibrillation, Attention deficit hyperactivity disorder, Benign prostatic hyperplasia, Beta blocker, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Beta-3 adrenergic receptor, Biosynthesis, Bladder stone, Blood pressure, Brain, Brown adipose tissue, Calcium, Catechol-O-methyltransferase, Catecholamine, Chemical synapse, Clonidine, Cnidaria, Cofactor (biochemistry), Ctenophora, Cyclic adenosine monophosphate, Cytosol, Demethylation, Deuterostome, Diabetes mellitus, ..., Dietary supplement, Dopamine, Dopamine beta-hydroxylase, Enteric nervous system, Enzyme, Erectile dysfunction, Exocytosis, Ferrous, Fight-or-flight response, Fluid replacement, G protein–coupled receptor, Gastrointestinal physiology, General anaesthesia, Generalized anxiety disorder, Gi alpha subunit, Gigantocellular reticular nucleus, Glaucoma, Glucagon, Gluconeogenesis, Glucose, Glycogenolysis, Gq alpha subunit, Gs alpha subunit, Guanfacine, Heart failure, Heart rate, Hemodynamics, Hormone, Human body, Hypertension, Hypothalamic–pituitary–adrenal axis, Immune system, Inositol trisphosphate, International nonproprietary name, International Olympic Committee, Iris dilator muscle, Isoprenaline, Ketamine, Kidney, L-DOPA, Lancelet, Lipolysis, Liver, Locus coeruleus, Lymph node, Marfan syndrome, Metabolic pathway, Metabolite, Methyl group, Methylphenidate, Migraine, Monoamine neurotransmitter, Monoamine oxidase, Monoamine oxidase A, Monoamine oxidase inhibitor, Mydriasis, Neurotransmitter, Nor-, Noradrenergic cell group A1, Noradrenergic cell group A2, Noradrenergic cell group A4, Noradrenergic cell group A5, Noradrenergic cell group A6, Noradrenergic cell group A7, Noradrenergic cell groups, Norepinephrine, Norepinephrine (medication), Norepinephrine transporter, Octopamine (neurotransmitter), Organic compound, Over-the-counter drug, Oxygen, Pancreas, Panic disorder, Parasympathetic nervous system, Paravertebral ganglia, Parkinson's disease, Pausinystalia johimbe, Phenethylamine, Phentolamine, Phenylalanine, Phenylalanine hydroxylase, Phenylethanolamine N-methyltransferase, Pheochromocytoma, Phospholipase C, Placozoa, Pons, Postganglionic nerve fibers, Posttraumatic stress disorder, Premedication, Prevertebral ganglia, Protostome, Protozoa, Pure autonomic failure, Pyridoxal phosphate, Reactive hypoglycemia, Receptor (biochemistry), Renin, Reuptake, S-Adenosyl methionine, Second messenger system, Septic shock, Serotonin, Skeletal muscle, Solitary nucleus, Spinal cord, Spleen, Stage fright, Stimulant, Stomach, Stress (biology), Surviving Sepsis Campaign, Sympathetic ganglion, Sympathetic nervous system, Sympathoadrenal system, Sympatholytic, Sympathomimetic drug, Synaptic vesicle, Tetrahydrobiopterin, Thymus, Tricyclic antidepressant, Tyrosine, Tyrosine hydroxylase, Ulf von Euler, Vanillylmandelic acid, Vasopressin, Vesicle (biology and chemistry), Vesicular monoamine transporter, Veterinary surgery, Vitamin C, Walter Bradford Cannon, Xylazine, Yohimbine, Zénon Bacq, 3-Methoxy-4-hydroxyphenylglycol. Expand index (135 more) »


The abdomen (less formally called the belly, stomach, tummy or midriff) constitutes the part of the body between the thorax (chest) and pelvis, in humans and in other vertebrates.

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Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals, including humans, as a neurotransmitter—a chemical message released by nerve cells to send signals to other cells.

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Action potential

In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.

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Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.

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Adipose tissue

In biology, adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes.

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Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

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Adrenal medulla

The adrenal medulla (medulla glandulae suprarenalis) is part of the adrenal gland.

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Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.

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Adrenergic receptor

The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).

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Alcohol dependence

Alcohol dependence is a previous psychiatric diagnosis in which an individual is physically or psychologically dependent upon alcohol (also known formally as ethanol).

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Alpha blocker

Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors).

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Alpha-1 adrenergic receptor

The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.

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Alpha-1 blocker

Alpha-1 blockers (also called alpha-adrenergic blocking agents) constitute a variety of drugs that block alpha-1-adrenergic receptors in arteries, smooth muscles, and central nervous system tissues.

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Alpha-2 adrenergic receptor

The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.

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Alpha-2 blocker

α2-blockers are a subset of the alpha blocker class of drugs and are antagonists to the α2 adrenergic receptor.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Amphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.

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Angina, also known as angina pectoris, is chest pain or pressure, usually due to not enough blood flow to the heart muscle.

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Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.

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Aromatic L-amino acid decarboxylase

Aromatic L-amino acid decarboxylase (AADC or AAAD), also known as DOPA decarboxylase (DDC), tryptophan decarboxylase, and 5-hydroxytryptophan decarboxylase, is a lyase enzyme.

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Arousal is the physiological and psychological state of being awoken or of sense organs stimulated to a point of perception.

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An artery (plural arteries) is a blood vessel that takes blood away from the heart to all parts of the body (tissues, lungs, etc).

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Arturo Rosenblueth

Arturo Rosenblueth Stearns (October 2, 1900 – September 20, 1970) was a Mexican researcher, physician and physiologist, who is known as one of the pioneers of cybernetics.

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Atomoxetine, sold under the brand name Strattera among others, is a norepinephrine (noradrenaline) reuptake inhibitor which is approved for the treatment of attention deficit hyperactivity disorder (ADHD).

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Atrial fibrillation

Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm characterized by rapid and irregular beating of the atria.

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Attention deficit hyperactivity disorder

Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.

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Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate.

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Beta blocker

Beta blockers, also written β-blockers, are a class of medications that are particularly used to manage abnormal heart rhythms, and to protect the heart from a second heart attack (myocardial infarction) after a first heart attack (secondary prevention).

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Beta-1 adrenergic receptor

The beta-1 adrenergic receptor (β1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it.

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Beta-2 adrenergic receptor

The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation.

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Beta-3 adrenergic receptor

The beta-3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it.

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Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.

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Bladder stone

A bladder stone is a stone found in the urinary bladder.

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Blood pressure

Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.

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The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

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Brown adipose tissue

Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat).

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Calcium is a chemical element with symbol Ca and atomic number 20.

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Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure.

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A catecholamine (CA) is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine.

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Chemical synapse

Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.

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Clonidine (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, tic disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions.

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Cnidaria is a phylum containing over 10,000 species of animals found exclusively in aquatic (freshwater and marine) environments: they are predominantly marine species.

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Ctenophora (singular ctenophore, or; from the Greek κτείς kteis 'comb' and φέρω pherō 'to carry'; commonly known as comb jellies) is a phylum of invertebrate animals that live in marine waters worldwide.

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Cyclic adenosine monophosphate

Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.

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The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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Demethylation is the chemical process resulting in the removal of a methyl group (CH3) from a molecule.

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Deuterostomes (taxonomic term: Deuterostomia; meaning "second mouth" in Greek) are any members of a superphylum of animals.

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Diabetes mellitus

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.

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Dietary supplement

A dietary supplement is a manufactured product intended to supplement the diet when taken by mouth as a pill, capsule, tablet, or liquid.

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Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Dopamine beta-hydroxylase

Dopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme that in humans is encoded by the DBH gene.

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Enteric nervous system

The enteric nervous system (ENS) or intrinsic nervous system is one of the main divisions of the autonomic nervous system (ANS) and consists of a mesh-like system of neurons that governs the function of the gastrointestinal tract.

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Enzymes are macromolecular biological catalysts.

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Erectile dysfunction

Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity.

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Exocytosis is a form of active transport in which a cell transports molecules (e.g., neurotransmitters and proteins) out of the cell (exo- + cytosis) by expelling them through an energy-dependent process.

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In chemistry, ferrous (Fe2+), indicates a divalent iron compound (+2 oxidation state), as opposed to ferric, which indicates a trivalent iron compound (+3 oxidation state).

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Fight-or-flight response

The fight-or-flight response (also called hyperarousal, or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival.

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Fluid replacement

Fluid replacement or fluid resuscitation is the medical practice of replenishing bodily fluid lost through sweating, bleeding, fluid shifts or other pathologic processes.

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G protein–coupled receptor

G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.

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Gastrointestinal physiology

Gastrointestinal physiology is the branch of human physiology that addresses the physical function of the gastrointestinal (GI) tract.

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General anaesthesia

General anaesthesia or general anesthesia (see spelling differences) is a medically induced coma with loss of protective reflexes, resulting from the administration of one or more general anaesthetic agents.

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Generalized anxiety disorder

Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry, that is, apprehensive expectation about events or activities.

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Gi alpha subunit

Gi alpha subunit (Gαi, or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.

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Gigantocellular reticular nucleus

The gigantocellular nucleus is a subregion of the medullary reticular formation.

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Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.

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Glucagon is a peptide hormone, produced by alpha cells of the pancreas.

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Gluconeogenesis (GNG) is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates.

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Glucose is a simple sugar with the molecular formula C6H12O6.

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Glycogenolysis is the breakdown of glycogen (n) to glucose-6-phosphate and glycogen (n-1).

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Gq alpha subunit

Gq protein (Gαq, or Gq/11) is a heterotrimeric G protein subunit that activates phospholipase C (PLC).

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Gs alpha subunit

The Gs alpha subunit (Gαs, Gsα, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase.

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Guanfacine (trade names Estulic, Tenex, and, in extended release form, Intuniv) is a sympatholytic drug used to treat hypertension and attention deficit hyperactivity disorder (ADHD).

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Heart failure

Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.

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Heart rate

Heart rate is the speed of the heartbeat measured by the number of contractions of the heart per minute (bpm).

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Hemodynamics or hæmodynamics is the dynamics of blood flow.

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A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Human body

The human body is the entire structure of a human being.

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Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Hypothalamic–pituitary–adrenal axis

The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland (a pea-shaped structure located below the thalamus), and the adrenal (also called "suprarenal") glands (small, conical organs on top of the kidneys).

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Inositol trisphosphate

Inositol trisphosphate or inositol 1,4,5-trisphosphate (also commonly known as triphosphoinositol; abbreviated InsP3 or Ins3P or IP3), together with diacylglycerol (DAG), is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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International Olympic Committee

The International Olympic Committee (IOC; French: Comité International Olympique, CIO) is a Swiss private non-governmental organisation based in Lausanne, Switzerland, which is the authority responsible for the modern Olympic Games.

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Iris dilator muscle

The iris dilator muscle (pupil dilator muscle, pupillary dilator, radial muscle of iris, radiating fibers), is a smooth muscle of the eye, running radially in the iris and therefore fit as a dilator.

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Isoprenaline, or isoproterenol, is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma.

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Ketamine, sold under the brand name Ketalar among others, is a medication mainly used for starting and maintaining anesthesia.

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The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.

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The lancelets — also known as amphioxi (singular, amphioxus) consist of about 32 species of fish-like marine chordates in the order Amphioxiformes.

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Lipolysis is the breakdown of lipids and involves hydrolysis of triglycerides into glycerol and free fatty acids.

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The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Locus coeruleus

The locus coeruleus (\-si-ˈrü-lē-əs\, also spelled locus caeruleus or locus ceruleus) is a nucleus in the pons of the brainstem involved with physiological responses to stress and panic.

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Lymph node

A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.

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Marfan syndrome

Marfan syndrome (MFS) is a genetic disorder of the connective tissue.

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Metabolic pathway

In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.

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A metabolite is the intermediate end product of metabolism.

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Methyl group

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.

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Methylphenidate, sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

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A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe.

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Monoamine neurotransmitter

Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.

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Monoamine oxidase

L-Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines.

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Monoamine oxidase A

Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the MAOA gene.

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Monoamine oxidase inhibitor

Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).

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Mydriasis is the dilation of the pupil, usually having a non-physiological cause, or sometimes a physiological pupillary response.

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Neurotransmitters are endogenous chemicals that enable neurotransmission.

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In chemical nomenclature, nor- is a prefix to name a structural analog that can be derived from a parent compound by the removal of one carbon atom along with the accompanying hydrogen atoms.

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Noradrenergic cell group A1

Noradrenergic cell group A1 is a group of cells in the vicinity of the lateral reticular nucleus of the medullary reticular formation that label for norepinephrine in primates and rodents.

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Noradrenergic cell group A2

Noradrenergic cell group A2 is a group of cells in the vicinity of the dorsal motor nucleus of the vagus nerve in the medulla that label for norepinephrine in primates and rodents.

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Noradrenergic cell group A4

Noradrenergic cell group A4 is a group of cells exhibiting noradrenergic fluorescence that, in the rat, are located in the Tegmen ventriculi quarti (roof of the fourth ventricle) ventral to the cerebellar nuclei, and in the macaque, are found at the edge of the lateral recess of the fourth ventricle caudally, extending to beneath the floor of the ventricle where they merge with the noradrenergic group A6, the locus ceruleus.

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Noradrenergic cell group A5

Noradrenergic cell group A5 is a group of cells in the vicinity of the superior olivary complex in the pontine tegmentum that label for norepinephine in primates, rodents and other mammals.

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Noradrenergic cell group A6

Noradrenergic cell group A6 is a group of cells fluorescent for noradrenaline that are identical with the locus ceruleus, as identified by Nissl stain.

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Noradrenergic cell group A7

Noradrenergic cell group A7 is a group of cells fluorescent for norepinephrine that is located in the pontine reticular formation ventral to the superior cerebellar peduncle of the pons in rodents and in primates.

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Noradrenergic cell groups

Noradrenergic cell groups refers to collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin).

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Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

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Norepinephrine (medication)

Norepinephrine, also known as noradrenaline, is a medication used to treat people with very low blood pressure.

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Norepinephrine transporter

The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.

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Octopamine (neurotransmitter)

Octopamine is an organic chemical closely related to norepinephrine, and synthesized biologically by a homologous pathway.

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Organic compound

In chemistry, an organic compound is generally any chemical compound that contains carbon.

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Over-the-counter drug

Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a prescription from a healthcare professional, as opposed to prescription drugs, which may be sold only to consumers possessing a valid prescription.

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Oxygen is a chemical element with symbol O and atomic number 8.

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The pancreas is a glandular organ in the digestive system and endocrine system of vertebrates.

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Panic disorder

Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks.

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Parasympathetic nervous system

The parasympathetic nervous system (PSNS) is one of the two divisions of the autonomic nervous system (a division of the peripheral nervous system (PNS)), the other being the sympathetic nervous system.

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Paravertebral ganglia

Along the length of the sympathetic trunks are ganglia known as ganglia of sympathetic trunk, sympathetic ganglia or paravertebral ganglia.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Pausinystalia johimbe

Pausinystalia johimbe, (Rubiaceae), common name Yohimbe, is a plant species native to western and central Africa (Nigeria, Cabinda, Cameroon, Congo-Brazzaville, Gabon, Equatorial Guinea).

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Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans.

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Phentolamine (Regitine) is a reversible nonselective α-adrenergic antagonist.

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Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.

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Phenylalanine hydroxylase

Phenylalanine hydroxylase (PAH) is an enzyme that catalyzes the hydroxylation of the aromatic side-chain of phenylalanine to generate tyrosine.

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Phenylethanolamine N-methyltransferase

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found primarily in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline).

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Pheochromocytoma (PCC) is a neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue that failed to involute after birth, that secretes high amounts of catecholamines, mostly norepinephrine, plus epinephrine to a lesser extent.

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Phospholipase C

Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).

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The Placozoa are a basal form of free-living (non-parasitic) multicellular organism.

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The pons (Latin for "bridge") is part of the brainstem, and in humans and other bipeds lies inferior to the midbrain, superior to the medulla oblongata and anterior to the cerebellum.

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Postganglionic nerve fibers

In the autonomic nervous system, fibers from the ganglion to the effector organ are called postganglionic fibers.

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Posttraumatic stress disorder

Posttraumatic stress disorder (PTSD)Acceptable variants of this term exist; see the Terminology section in this article.

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Premedication is using medication before some other therapy (usually surgery or chemotherapy) to prepare for that forthcoming therapy.

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Prevertebral ganglia

Prevertebral ganglia (or collateral ganglia, or preaortic ganglia) are sympathetic ganglia which lie between the paravertebral ganglia and the target organ.

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Protostomia (from Greek πρωτο- proto- "first" and στόμα stoma "mouth") is a clade of animals.

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Protozoa (also protozoan, plural protozoans) is an informal term for single-celled eukaryotes, either free-living or parasitic, which feed on organic matter such as other microorganisms or organic tissues and debris.

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Pure autonomic failure

Pure autonomic failure (PAF) is a form of dysautonomia that first occurs in middle age or later in life; men are affected more often than women.

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Pyridoxal phosphate

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions.

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Reactive hypoglycemia

Reactive hypoglycemia, postprandial hypoglycemia, or sugar crash is a term describing recurrent episodes of symptomatic hypoglycemia occurring within 4 hours"Hypoglycemia." It can also be referred to as "sugar crash" or "glucose crash." National Diabetes Information Clearinghouse, October 2008.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.

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Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

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S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.

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Second messenger system

Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers.

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Septic shock

Septic shock is a serious medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

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Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Skeletal muscle

Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle.

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Solitary nucleus

In the human brainstem, the solitary nucleus (SN) (nucleus of the solitary tract, nucleus solitarius, nucleus tractus solitarii) is a series of purely sensory nuclei (clusters of nerve cell bodies) forming a vertical column of grey matter embedded in the medulla oblongata.

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Spinal cord

The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column.

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The spleen is an organ found in virtually all vertebrates.

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Stage fright

Stage fright or performance anxiety is the anxiety, fear, or persistent phobia which may be aroused in an individual by the requirement to perform in front of an audience, whether actually or potentially (for example, when performing before a camera).

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Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.

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The stomach (from ancient Greek στόμαχος, stomachos, stoma means mouth) is a muscular, hollow organ in the gastrointestinal tract of humans and many other animals, including several invertebrates.

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Stress (biology)

Physiological or biological stress is an organism's response to a stressor such as an environmental condition.

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Surviving Sepsis Campaign

The Surviving Sepsis Campaign (SSC) is a global initiative to bring together professional organizations in reducing mortality from sepsis.

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Sympathetic ganglion

Sympathetic ganglia are the ganglia of the sympathetic nervous system.

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Sympathetic nervous system

The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the parasympathetic nervous system.

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Sympathoadrenal system

The sympathoadrenal system is a physiological connection between the sympathetic nervous system and the adrenal medulla and is crucial in an organism’s physiological response to outside stimuli.

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A sympatholytic (or sympathoplegic) drug is a medication that opposes the downstream effects of postganglionic nerve firing in effector organs innervated by the sympathetic nervous system (SNS).

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Sympathomimetic drug

Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system.

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Synaptic vesicle

In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse.

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Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases.

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The thymus is a specialized primary lymphoid organ of the immune system.

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Tricyclic antidepressant

Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.

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Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.

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Tyrosine hydroxylase

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA).

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Ulf von Euler

Ulf Svante von Euler (7 February 1905 – 9 March 1983) was a Swedish physiologist and pharmacologist.

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Vanillylmandelic acid

Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines, epinephrine, and norepinephrine.

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Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.

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Vesicle (biology and chemistry)

In cell biology, a vesicle is a small structure within a cell, or extracellular, consisting of fluid enclosed by a lipid bilayer.

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Vesicular monoamine transporter

The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membrane of synaptic vesicles of presynaptic neurons.

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Veterinary surgery

Veterinary surgery is surgery performed on animals by veterinarians, whereby the procedures fall into three broad categories: orthopaedics (bones, joints, muscles), soft tissue surgery (skin, body cavities, cardiovascular system, GI/urogenital/respiratory tracts), and neurosurgery. Advanced surgical procedures such as joint replacement (total hip, knee and elbow replacement), fracture repair, stabilization of cranial cruciate ligament deficiency, oncologic (cancer) surgery, herniated disc treatment, complicated gastrointestinal or urogenital procedures, kidney transplant, skin grafts, complicated wound management, minimally invasive procedures (arthroscopy, laparoscopy, thoracoscopy) are performed by veterinary surgeons (as registered in their jurisdiction). Most general practice veterinarians perform routine surgery, some also perform additional procedures. The goal of veterinary surgery may be quite different in pets and in farm animals. In the former, the situation is more close to that with human beings, where the benefit to the patient is the important factor. In the latter, the economic benefit is more important.

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Vitamin C

Vitamin C, also known as ascorbic acid and L-ascorbic acid, is a vitamin found in food and used as a dietary supplement.

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Walter Bradford Cannon

Walter Bradford Cannon (October 19, 1871 – October 1, 1945) was an American physiologist, professor and chairman of the Department of Physiology at Harvard Medical School.

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Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor.

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Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree in Central Africa.

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Zénon Bacq

Zénon Bacq (31 December 1903 in La Louvière – 12 July 1983 in Fontenoy) was a Belgian radiobiologist and inventor.

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3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation.

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Redirects here:

ATC code C01CA03, ATCvet code QC01CA03, Arterenol, Levarterenol, Levophed, Modulatory arousal system, Noepinephrine, Nonadrenaline, Noradrenalin, Noradrenaline, Noradrenaline/Norepinephrine, Noradrenergic, Norepi, Norepinephrine degradation, Novepinephrine, Uptake 1, Uptake 2.


[1] https://en.wikipedia.org/wiki/Norepinephrine

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