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Norethisterone

Index Norethisterone

Norethisterone, also known as norethindrone and sold under the brand names Aygestin and Primolut N among many others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders. [1]

226 relations: Absorption (pharmacology), Acetic acid, Acetylene, Acetylide, Acne, Active metabolite, Agonist, Aldosterone, Alkyl, Alkynylation, Allopregnanolone, Allyl group, Allylestrenol, Altrenogest, Amenorrhea, Anabolic steroid, Androgen, Androgen receptor, Antiglucocorticoid, Antigonadotropin, Antimineralocorticoid, Antiprogestogen, Aromatase, Aromatase inhibitor, Bioassay, Bioavailability, Biological half-life, Biological target, Biotransformation, Bleeding, Bloating, Blood pressure, Bolandione, Bosentan, Breakthrough bleeding, Breast, Breast cancer, Breast enlargement, Breast pain, Carbamazepine, Carl Djerassi, Chemical structure, Chlorine, Cholesterol side-chain cleavage enzyme, Chromium trioxide, Coagulation, Combined oral contraceptive pill, Cyanomethyl, CYP17A1, CYP2C9, ..., CYP3A4, Danazol, Decidualization, Derivative (chemistry), Desogestrel, Dienogest, Diuretic, Double bond, Dutasteride, Dysfunctional uterine bleeding, Dysmenorrhea, Elimination (pharmacology), Emotional lability, Endometriosis, Endometrium, Enzyme inducer, Enzyme inhibitor, Estradiol (medication), Estrane, Estrogen (medication), Estrogen receptor, Estrogen receptor alpha, Estrogen receptor beta, Estrone, Ethinylestradiol, Ethisterone, Ethynyl, Etonogestrel, Etynodiol, Etynodiol diacetate, Feces, Finasteride, Follicle-stimulating hormone, Functional group, GABAA receptor, Gastrointestinal tract, Generic drug, George Rosenkranz, Gestodene, Gestrinone, Glucocorticoid, Glucocorticoid receptor, Glucuronidation, Gonane, Gynaecology, Gynecomastia, Headache, Hematopoietic stem cell transplantation, Hepatic veno-occlusive disease, High-density lipoprotein, Hirsutism, Hoarse voice, Hormone, Hot flash, Human serum albumin, Hydrochloride, Hydrocortisone, Hydroxylation, Hydroxyprogesterone caproate, Hypericum perforatum, Hypogonadism, IC50, Impaired glucose tolerance, Intellectual disability, Intramuscular injection, Irregular menstruation, Isomer, Ketone, Labioscrotal swelling, Leuprorelin, Levonorgestrel, Ligand (biochemistry), Liver, Luis E. Miramontes, Luteinizing hormone, Lynestrenol, Male contraceptive, Medicine, Medroxyprogesterone acetate, Megestrol acetate, Menopause, Menorrhagia, Menstrual disorder, Menstruation, Mestranol, Metabolism, Metabolite, Methyl group, Metribolone, Mexico City, Micronization, Mineralocorticoid, Mineralocorticoid receptor, Miscarriage, Molar concentration, Mood (psychology), Nandrolone, Nausea, Norelgestromin, Norethandrolone, Norethisterone acetate, Norethisterone enanthate, Noretynodrel, Norgesterone, Norgestimate, Norgestrel, Norgestrienone, Normethandrone, Norvinisterone, Oppenauer oxidation, Oral administration, Oral contraceptive pill, Organic compound, Ovulation, Oxendolone, Parent structure, Pharmacodynamics, Pituitary gland, Postmenopausal hormone therapy, Potassium tert-butoxide, Potency (pharmacology), Pregnancy, Premenstrual syndrome, Prodrug, Progesterone, Progesterone (medication), Progesterone receptor, Progestin, Progestogen, Progestogen-only pill, Promegestone, Prostate, Quingestanol acetate, Rifampicin, Sebaceous gland, Secretion, Sex hormone receptor, Sex hormone-binding globulin, Sex organ, Side effect, Sperm, Steric effects, Steroid, Steroid 11β-hydroxylase, Substrate (chemistry), Sulfation, Symptom, Syntex, Testicle, Testosterone, Testosterone (medication), Thermogenesis, Tibolone, Tolerability, Triethyl orthoformate, Urine, Uterus, Vagina, Vasodilation, Venous thrombosis, Vinyl group, Virilization, Voice change, Vomiting, Water retention (medicine), Weight gain, 17α-Methylprogesterone, 19-Norprogesterone, 21-Hydroxylase, 3α-Androstanediol, 3α-Hydroxysteroid dehydrogenase, 3β-Hydroxysteroid dehydrogenase, 5α-Dihydronorethisterone, 5α-Reductase, 5α-Reductase inhibitor, 5β-Reductase. Expand index (176 more) »

Absorption (pharmacology)

In pharmacology (and more specifically pharmacokinetics), absorption is the movement of a drug from the site of administration to bloodstream.

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Acetic acid

Acetic acid, systematically named ethanoic acid, is a colourless liquid organic compound with the chemical formula CH3COOH (also written as CH3CO2H or C2H4O2).

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Acetylene

Acetylene (systematic name: ethyne) is the chemical compound with the formula C2H2.

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Acetylide

Acetylide refers to chemical compounds with the chemical formulas MC≡CH and MC≡CM, where M is a metal.

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Acne

Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin.

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Active metabolite

An active metabolite is an active form of a drug after it has been processed by the body.

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Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Aldosterone

Aldosterone, the main mineralocorticoid hormone, is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland.

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Alkyl

In organic chemistry, an alkyl substituent is an alkane missing one hydrogen.

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Alkynylation

Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an α-alkynyl alcohol.

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Allopregnanolone

Allopregnanolone, also known as 5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), as well as brexanolone, is an endogenous inhibitory pregnane neurosteroid.

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Allyl group

An allyl group is a substituent with the structural formula H2C.

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Allylestrenol

Allylestrenol, sold under the brand names Gestanin and Turinal among others, is a progestin medication which is used to treat recurrent and threatened miscarriage and to prevent premature labor in pregnant women.

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Altrenogest

Altrenogest, sold under the brand names Regumate and Matrix, is a progestin of the 19-nortestosterone group which is widely used in veterinary medicine to suppress or synchronize estrus in horses and pigs.

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Amenorrhea

Amenorrhoea is the absence of a menstrual period in a woman of reproductive age.

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Anabolic steroid

Anabolic steroids, also known more properly as anabolic–androgenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects to testosterone.

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Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

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Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.

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Antiglucocorticoid

An antiglucocorticoid is a drug which reduces glucocorticoid activity in the body.

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Antigonadotropin

An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

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Antimineralocorticoid

An antimineralocorticoid, MCRA, or an aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors.

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Antiprogestogen

Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body.

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Aromatase

Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens.

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Aromatase inhibitor

Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and gynecomastia in men.

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Bioassay

A bioassay is an analytical method to determine concentration or potency of a substance by its effect on living cells or tissues.

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Bioavailability

In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.

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Biological half-life

The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.

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Biological target

A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.

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Biotransformation

Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound.

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Bleeding

Bleeding, also known as hemorrhaging or haemorrhaging, is blood escaping from the circulatory system.

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Bloating

Abdominal bloating is a symptom that can appear at any age, generally associated with functional gastrointestinal disorders or organic diseases, but can also appear alone.

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Blood pressure

Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.

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Bolandione

Bolandione, also known as 19-norandrostenedione, as well as 19-norandrost-4-en-3,17-dione or estr-4-ene-3,17-dione, is a precursor of the anabolic-androgenic steroid (AAS) nandrolone (19-nortestosterone).

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Bosentan

Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary artery hypertension (PAH).

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Breakthrough bleeding

Breakthrough bleeding (BTB) is any of various forms of vaginal bleeding,, in turn citing.

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Breast

The breast is one of two prominences located on the upper ventral region of the torso of primates.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Breast enlargement

Breast enlargement is the enlargement of the breasts.

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Breast pain

Breast pain is a medical symptom that is most often associated with a developing disease or condition of the breast.

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Carbamazepine

Carbamazepine (CBZ), sold under the tradename Tegretol, among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.

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Carl Djerassi

Carl Djerassi (October 29, 1923 – January 30, 2015) was an Austrian-born Bulgarian-American chemist, novelist, playwright and co-founder of with Diane Wood Middlebrook.

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Chemical structure

A chemical structure determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid.

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Chlorine

Chlorine is a chemical element with symbol Cl and atomic number 17.

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Cholesterol side-chain cleavage enzyme

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage.

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Chromium trioxide

Chromium trioxide is an inorganic compound with the formula CrO3.

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Coagulation

Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.

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Combined oral contraceptive pill

The combined oral contraceptive pill (COCP), often referred to as the birth control pill or colloquially as "the pill", is a type of birth control that is designed to be taken orally by women.

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Cyanomethyl

In organic chemistry, the term cyanomethyl (cyanide (N≡C) + methyl (CH3)) designates.

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CYP17A1

Cytochrome P450 17A1, also called steroid 17α-monooxygenase, 17α-hydroxylase, 17,20-lyase, or 17,20-desmolase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.

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CYP2C9

Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.

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CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.

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Danazol

Danazol, sold under the brand name Danocrine among others, is a medication which is used in the treatment of endometriosis, fibrocystic breast disease, hereditary angioedema, and other conditions.

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Decidualization

Decidualization is a process that results in significant changes to cells of the endometrium in preparation for, and during, pregnancy.

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Derivative (chemistry)

In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.

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Desogestrel

Desogestrel, sold under the brand names Cerazette and Mircette among many others, is a progestin medication which is used in birth control pills for women.

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Dienogest

Dienogest, sold under the brand names Natazia and Qlaira among others, is a progestin medication which is used in birth control pills and in the treatment of endometriosis.

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Diuretic

A diuretic is any substance that promotes diuresis, the increased production of urine.

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Double bond

A double bond in chemistry is a chemical bond between two chemical elements involving four bonding electrons instead of the usual two.

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Dutasteride

Dutasteride, sold under the brand name Avodart among others, is a medication used primarily to treat enlarged prostate in men.

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Dysfunctional uterine bleeding

Dysfunctional uterine bleeding (DUB) is abnormal genital tract bleeding based in the uterus and found in the absence of demonstrable structural or organic disease.

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Dysmenorrhea

Dysmenorrhea, also known as painful periods, or menstrual cramps, is pain during menstruation.

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Elimination (pharmacology)

In pharmacology the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.

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Emotional lability

In medicine and psychology, emotional lability is a sign or symptom typified by exaggerated changes in mood or affect in quick succession.

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Endometriosis

Endometriosis is a condition in which the endometrium, the layer of tissue that normally covers the inside of the uterus, grows outside of it.

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Endometrium

The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus.

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Enzyme inducer

An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme.

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Enzyme inhibitor

4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Estradiol (medication)

Estradiol, also spelled oestradiol, is a medication and naturally occurring steroid hormone.

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Estrane

Estrane is a C18 steroid derivative, with a gonane core.

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Estrogen (medication)

An estrogen is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.

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Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

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Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.

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Estrogen receptor beta

Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is one of two main types of estrogen receptor, a nuclear receptor which is activated by the sex hormone estrogen.

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Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone.

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Ethinylestradiol

Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins.

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Ethisterone

Ethisterone, also known as ethinyltestosterone, pregneninolone, and anhydrohydroxyprogesterone and formerly sold under the brand names Proluton C and Pranone among others, is a progestin medication which was used in the treatment of gynecological disorders but is now no longer available.

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Ethynyl

In organic chemistry, the term ethynyl designates.

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Etonogestrel

Etonogestrel is a progestin medication which is used as a means of birth control for women.

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Etynodiol

Etynodiol, or ethynodiol, is a steroidal progestin of the 19-nortestosterone group which was never marketed.

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Etynodiol diacetate

Etynodiol diacetate, or ethynodiol diacetate, sold under the brand names Demulen and Femulen among others, is a progestin medication which is used in birth control pills.

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Feces

Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.

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Finasteride

Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used mainly to treat an enlarged prostate or scalp hair loss in men.

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Follicle-stimulating hormone

Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone.

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Functional group

In organic chemistry, functional groups are specific substituents or moieties within molecules that are responsible for the characteristic chemical reactions of those molecules.

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GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

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Gastrointestinal tract

The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.

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Generic drug

A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.

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George Rosenkranz

George Rosenkranz (born György Rosenkranz, August 20, 1916) is a pioneering Mexican scientist in the field of steroid chemistry, who used native Mexican plant sources as raw materials.

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Gestodene

Gestodene, sold under the brand names Femodene and Minulet among others, is a progestin medication which is used in birth control pills for women.

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Gestrinone

Gestrinone, sold under the brand names Dimetrose and Nemestran among others, is a medication which is used in the treatment of endometriosis.

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Glucocorticoid

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.

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Glucocorticoid receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.

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Glucuronidation

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

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Gonane

Gonane (C17), also known as perhydrocyclopentaphenanthrene, is a tetracyclic hydrocarbon ring structure and the fundamental steroid nucleus.

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Gynaecology

Gynaecology or gynecology (see spelling differences) is the medical practice dealing with the health of the female reproductive systems (vagina, uterus, and ovaries) and the breasts.

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Gynecomastia

Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.

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Headache

Headache is the symptom of pain anywhere in the region of the head or neck.

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Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.

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Hepatic veno-occlusive disease

Hepatic veno-occlusive disease or veno-occlusive disease with immunodeficiency (VODI) is a condition in which some of the small veins in the liver are obstructed.

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High-density lipoprotein

High-density lipoproteins (HDL) are one of the five major groups of lipoproteins.

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Hirsutism

Hirsutism is excessive body hair in men and women on parts of the body where hair is normally absent or minimal, such as on the chin or chest in particular, or the face or body in general.

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Hoarse voice

A hoarse voice, also known as hoarseness or dysphonia, is when the voice involuntarily sounds breathy, raspy, or strained, or is softer in volume or lower in pitch.

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Hormone

A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Hot flash

Hot flashes (American English) or hot flushes (British English) are a form of flushing due to reduced levels of estradiol.

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Human serum albumin

Human serum albumin is the serum albumin found in human blood.

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Hydrochloride

In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).

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Hydrocortisone

Hydrocortisone, sold under a number of brand names, is the name for the hormone cortisol when supplied as a medication.

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Hydroxylation

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.

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Hydroxyprogesterone caproate

Hydroxyprogesterone caproate (OHPC), sold under the brand names Proluton and Makena among others, is a progestin medication which is used to prevent preterm birth in pregnant women with a history of the condition and to treat gynecological disorders.

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Hypericum perforatum

Hypericum perforatum, known as perforate St John's-wort, common Saint John's wort and St John's wort, is a flowering plant in the family Hypericaceae.

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Hypogonadism

Hypogonadism means diminished functional activity of the gonads—the testes or the ovaries —that may result in diminished sex hormone biosynthesis.

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IC50

The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.

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Impaired glucose tolerance

Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology.

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Intellectual disability

Intellectual disability (ID), also known as general learning disability, and mental retardation (MR), is a generalized neurodevelopmental disorder characterized by significantly impaired intellectual and adaptive functioning.

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Intramuscular injection

Intramuscular (also IM or im) injection is the injection of a substance directly into muscle.

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Irregular menstruation

Irregular menstruation is a menstrual disorder whose manifestations include irregular cycle lengths as well as metrorrhagia (vaginal bleeding between expected periods).

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Isomer

An isomer (from Greek ἰσομερής, isomerès; isos.

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Ketone

In chemistry, a ketone (alkanone) is an organic compound with the structure RC(.

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Labioscrotal swelling

The labioscrotal swellings (genital swellings or labioscrotal folds) are paired structures in the human embryo that represent the final stage of development of the caudal end of the external genitals before sexual differentiation.

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Leuprorelin

Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.

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Levonorgestrel

Levonorgestrel is a hormonal medication which is used in a number of birth control methods.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Luis E. Miramontes

Luis Ernesto Miramontes Cárdenas (March 16, 1925 – September 13, 2004) was a Mexican chemist known as the co-inventor of the progestin norethisterone used in one of the first three oral contraceptives.

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Luteinizing hormone

Luteinizing hormone (LH, also known as lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland.

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Lynestrenol

Lynestrenol, sold under the brand names Exluton and Ministat among others, is a progestin medication which is used in birth control pills and in the treatment of gynecological disorders.

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Male contraceptive

Male contraceptives, also known as male birth control are methods of preventing pregnancy that primarily involve the male physiology.

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Medicine

Medicine is the science and practice of the diagnosis, treatment, and prevention of disease.

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Medroxyprogesterone acetate

Medroxyprogesterone acetate (MPA), sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type.

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Megestrol acetate

Megestrol acetate (MGA), sold under the brand name Megace among others, is a progestin medication which is used mainly as an appetite stimulant to treat wasting syndromes such as cachexia.

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Menopause

Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.

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Menorrhagia

Menorrhagia is a menstrual period with excessively heavy flow and falls under the larger category of abnormal uterine bleeding (AUB).

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Menstrual disorder

A menstrual disorder is an abnormal condition in a woman's menstrual cycle.

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Menstruation

Menstruation, also known as a period or monthly, is the regular discharge of blood and mucosal tissue (known as menses) from the inner lining of the uterus through the vagina.

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Mestranol

Mestranol, sold under the brand names Enovid, Norinyl, and Ortho-Novum among others, is an estrogen medication which has been used in birth control pills, menopausal hormone therapy, and the treatment of menstrual disorders.

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Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Metabolite

A metabolite is the intermediate end product of metabolism.

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Methyl group

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.

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Metribolone

Metribolone (developmental code name R1881), also known as methyltrienolone, is a synthetic and orally active anabolic–androgenic steroid (AAS) and a 17α-alkylated nandrolone (19-nortestosterone) derivative which was never marketed for medical use but has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR.

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Mexico City

Mexico City, or the City of Mexico (Ciudad de México,; abbreviated as CDMX), is the capital of Mexico and the most populous city in North America.

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Micronization

Micronization is the process of reducing the average diameter of a solid material's particles.

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Mineralocorticoid

Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones.

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Mineralocorticoid receptor

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.

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Miscarriage

Miscarriage, also known as spontaneous abortion and pregnancy loss, is the natural death of an embryo or fetus before it is able to survive independently.

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Molar concentration

Molar concentration (also called molarity, amount concentration or substance concentration) is a measure of the concentration of a chemical species, in particular of a solute in a solution, in terms of amount of substance per unit volume of solution.

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Mood (psychology)

In psychology, a mood is an emotional state.

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Nandrolone

Nandrolone, also known as 19-nortestosterone, is an androgen and anabolic steroid (AAS) which is used in the form of esters such as nandrolone decanoate (brand name Deca-Durabolin) and nandrolone phenylpropionate (brand name Durabolin).

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Nausea

Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.

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Norelgestromin

Norelgestromin, or norelgestromine, sold under the brand names Evra and Ortho Evra among others, is a progestin medication which is used as a method of birth control for women.

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Norethandrolone

Norethandrolone, sold under the brand names Nilevar and Pronabol among others, is an androgen and anabolic steroid (AAS) medication which has been used to promote muscle growth and to treat severe burns, physical trauma, and aplastic anemia but has mostly been discontinued.

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Norethisterone acetate

Norethisterone acetate (NETA), also known as norethindrone acetate and sold under the brand name Primolut-Nor among others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.

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Norethisterone enanthate

Norethisterone enanthate (NETE), also known as norethindrone enanthate, is a form of progestogen-only injectable birth control.

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Noretynodrel

Noretynodrel, or norethynodrel, sold under the brand name Enovid among others, is a progestin medication which was previously used in birth control pills and in the treatment of gynecological disorders but is now no longer marketed. It was available both alone and in combination with an estrogen. The medication is taken by mouth. Noretynodrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It is a relatively weak progestogen. The medication has weak estrogenic activity, no or only very weak androgenic activity, and no other important hormonal activity. It is a prodrug of various active metabolites in the body, such as norethisterone among others. Noretynodrel was introduced for medical use in 1957. It was specifically approved at this time in combination with mestranol for the treatment of gynecological and menstrual disorders. Subsequently, in 1960, this formulation was approved for use as a birth control pill. It was the first birth control pill to be introduced, and was followed by birth control pills containing norethisterone and other progestins shortly thereafter. Due to its nature as a relatively weak progestogen, noretynodrel is no longer used in medicine. As such, it is no longer marketed.

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Norgesterone

Norgesterone, also known as norvinodrel or vinylestrenolone and sold under the brand name Vestalin, is a progestin medication which was formerly used in birth control pills for women but is now no longer marketed.

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Norgestimate

Norgestimate, sold under the brand names Ortho Tri-Cyclen and Previfem among others, is a progestin medication which is used in birth control pills for women and in menopausal hormone therapy.

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Norgestrel

Norgestrel, sold under the brand name Ovral among others, is a progestin medication which is used in birth control pills and in menopausal hormone therapy.

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Norgestrienone

Norgestrienone, sold under the brand names Ogyline, Planor, and Miniplanor, is a progestin medication which has been used in birth control pills, sometimes in combination with ethinylestradiol.

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Normethandrone

Normethandrone, also known as methylestrenolone or methylnortestosterone and sold under the brand name Metalutin among others, is a progestin and androgen/anabolic steroid (AAS) medication which is used in combination with an estrogen in the treatment of amenorrhea and menopausal symptoms in women.

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Norvinisterone

Norvinisterone, sold under the brand names Neoprogestin and Nor-Progestelea, is a progestin and androgen/anabolic steroid (AAS) medication which was used in Europe but is now no longer marketed.

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Oppenauer oxidation

Oppenauer oxidation, named after Rupert Viktor Oppenauer, is a gentle method for selectively oxidizing secondary alcohols to ketones.

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Oral administration

| name.

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Oral contraceptive pill

Oral contraceptives, abbreviated OCPs, also known as birth control pills, are medications taken by mouth for the purpose of birth control.

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Organic compound

In chemistry, an organic compound is generally any chemical compound that contains carbon.

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Ovulation

Ovulation is the release of eggs from the ovaries.

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Oxendolone

Oxendolone, sold under the brand names Prostetin and Roxenone, is an antiandrogen and progestin medication which is used in Japan in the treatment of enlarged prostate.

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Parent structure

In IUPAC nomenclature, a parent structure, parent compound, parent name or simply parent is the denotation for a compound consisting of an unbranched chain of skeletal atoms (not necessarily carbon), or consisting of an unsubstituted monocyclic or polycyclic ring system.

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Pharmacodynamics

Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).

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Pituitary gland

An explanation of the development of the pituitary gland (Hypophysis cerebri) & the congenital anomalies. In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing in humans.

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Postmenopausal hormone therapy

Menopausal hormone therapy (MHT), or postmenopausal hormone therapy (PHT, PMHT), also known as hormone replacement therapy in menopause, is a form of hormone replacement therapy (HRT) which is used in postmenopausal, perimenopausal, and surgically menopausal women.

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Potassium tert-butoxide

Potassium tert-butoxide is the chemical compound with the formula K+(CH3)3CO−.

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Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

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Pregnancy

Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.

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Premenstrual syndrome

Premenstrual syndrome (PMS) refers to physical and emotional symptoms that occur in the one to two weeks before a woman's period.

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Prodrug

A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

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Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

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Progesterone (medication)

Progesterone is a medication and naturally occurring steroid hormone.

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Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

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Progestin

A progestin is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.

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Progestogen

Progestogens, also sometimes spelled progestagens or gestagens, are a class of steroid hormones that bind to and activate the progesterone receptor (PR).

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Progestogen-only pill

Progestogen-only pills or progestin-only pills (POP) are contraceptive pills that contain only synthetic progestogens (progestins) and do not contain estrogen.

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Promegestone

Promegestone, sold under the brand name Surgestone, is a progestin medication which is used in menopausal hormone therapy and in the treatment of gynecological disorders.

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Prostate

The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.

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Quingestanol acetate

Quingestanol acetate, sold under the brand names Demovis and Pilomin among others, is a progestin which was used in birth control pills but is no longer marketed.

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Rifampicin

Rifampicin, also known as rifampin, is an antibiotic used to treat several types of bacterial infections, including tuberculosis, leprosy, and Legionnaire's disease.

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Sebaceous gland

Sebaceous glands are microscopic exocrine glands in the skin that secrete an oily or waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals.

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Secretion

Secretion is the movement of material from one point to another, e.g. secreted chemical substance from a cell or gland.

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Sex hormone receptor

The sex hormone receptors, or sex steroid receptors, are a group of steroid hormone receptors that interact with the sex hormones, the androgens, estrogens, and progestogens, as well as with sex-hormonal agents such as anabolic steroids, progestins, and antiestrogens.

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Sex hormone-binding globulin

Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to the two sex hormones: androgen and estrogen.

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Sex organ

A sex organ (or reproductive organ) is any part of an animal's body that is involved in sexual reproduction.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Sperm

Sperm is the male reproductive cell and is derived from the Greek word (σπέρμα) sperma (meaning "seed").

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Steric effects

Steric effects are nonbonding interactions that influence the shape (conformation) and reactivity of ions and molecules.

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Steroid

A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

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Steroid 11β-hydroxylase

Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Sulfation

Sulfation or sulfurylation (not to be confused with sulfonation) in biochemistry is the enzyme-catalyzed conjugation of a sulfo group (not a sulfate or sulfuryl group) to another molecule.

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Symptom

A symptom (from Greek σύμπτωμα, "accident, misfortune, that which befalls", from συμπίπτω, "I befall", from συν- "together, with" and πίπτω, "I fall") is a departure from normal function or feeling which is noticed by a patient, reflecting the presence of an unusual state, or of a disease.

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Syntex

Laboratorios Syntex SA was a pharmaceutical company formed in Mexico City in 1944 by Russell Marker to manufacture therapeutic steroids from the Mexican yams called cabeza de negro (Dioscorea mexicana) and Barbasco (Dioscorea composita).

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Testicle

The testicle or testis is the male reproductive gland in all animals, including humans.

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Testosterone

Testosterone is the primary male sex hormone and an anabolic steroid.

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Testosterone (medication)

Testosterone is a medication and naturally occurring steroid hormone.

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Thermogenesis

Thermogenesis is the process of heat production in organisms.

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Tibolone

Tibolone, sold under the brand names Livial and Tibofem among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis.

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Tolerability

Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient.

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Triethyl orthoformate

Triethyl orthoformate is an organic compound with the formula HC(OC2H5)3.

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Urine

Urine is a liquid by-product of metabolism in humans and in many animals.

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Uterus

The uterus (from Latin "uterus", plural uteri) or womb is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.

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Vagina

In mammals, the vagina is the elastic, muscular part of the female genital tract.

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Vasodilation

Vasodilation is the widening of blood vessels.

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Venous thrombosis

A venous thrombus is a blood clot (thrombus) that forms within a vein.

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Vinyl group

In chemistry, vinyl or ethenyl is the functional group with the formula −CH.

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Virilization

Virilization or masculinization is the biological development of sex differences, changes that make a male body different from a female body.

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Voice change

A voice change or voice mutation, sometimes referred to as a voice break, commonly refers to the deepening of the voice of people as they reach puberty.

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Vomiting

Vomiting, also known as emesis, puking, barfing, throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.

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Water retention (medicine)

The term water retention (also known as fluid retention) or hydrops, hydropsy, edema, signifies an abnormal accumulation of clear, watery fluid in the tissues or cavities of the body.

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Weight gain

Weight gain is an increase in body weight.

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17α-Methylprogesterone

17α-Methylprogesterone (17α-MP), or 17α-methylpregn-4-ene-3,20-dione, is a steroidal progestin related to progesterone that was synthesized and characterized in 1949 but was never marketed.

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19-Norprogesterone

19-Norprogesterone, also known as 19-norpregn-4-ene-3,20-dione, is a steroidal progestin and close analogue of the sex hormone progesterone, lacking only the C19 methyl group of that molecule.

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21-Hydroxylase

Steroid 21-hydroxylase, also called steroid 21-monooxygenase, 21α-Hydroxylase, P450 21A2, and, less commonly 21β-Hydroxylase, is a cytochrome P450 enzyme that is involved with the biosynthesis of the steroid hormones aldosterone and cortisol.

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3α-Androstanediol

3α-Androstanediol (often abbreviated as 3α-diol), also known as 5α-androstane-3α,17β-diol, is an endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT).

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3α-Hydroxysteroid dehydrogenase

3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene.

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3β-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.

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5α-Dihydronorethisterone

5α-Dihydronorethisterone (5α-DHNET, dihydronorethisterone, 17α-ethynyl-5α-dihydro-19-nortestosterone, or 17α-ethynyl-5α-estran-17β-ol-3-one) is a major active metabolite of norethisterone (norethindrone).

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5α-Reductase

5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.

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5α-Reductase inhibitor

5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss.

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5β-Reductase

5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.

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Redirects here:

3-Ketoethynodiol, 3-Ketoetynodiol, 3-Ketolynestrenol, 3-ketoethynodiol, 3-ketoetynodiol, 3-ketolynestrenol, ATC code G03AC01, ATC code G03DC02, ATCvet code QG03AC01, ATCvet code QG03DC02, Anovulatorio, Anovule, Binovum, Ciclovulan, Conceplan, Conludaf, Conludag, Errin, Estrinor, Ethinylnortestosterone, Ethynylmortestosterone, Ethynylnortestosterone, Genora, Gestest, Incassia, Jencycla, Menzol, Microneth, Micronett, Micronor, Micronovum, Mini-Pe, Mini-Pill, Minovlar, Necon, Nelova, Nodiol, Nor-Q.D., Nor-QD, Nor-Qd, NorQ.D., NorQD, Noraethisteronum, Noralutin, Norcolut, Noresthisterone, Norethadrone, Norethindrone, Norethisteron, Norethyndron, Norethynodron, Norethynodrone, Noretisterone, Norfor, Norgestin, Noriday 28, Norimin, Norlutate, Norluten, Norlutin, Norluton, Normapause, Norpregneninlone, Norpregneninolone, Norpregneninotone, Orlest, Ortho 7 7 7, Perovex, Premolut N, Primolut, Primolut N, Primolut-N, Primolut-nor, Proluteasi, Synphase, Synphasic 28, Triella, Trinovum, Trinovum 21, Utovlan, Utovlar.

References

[1] https://en.wikipedia.org/wiki/Norethisterone

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