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27 relations: Bile acid, Biosynthesis, Cholesterol 7 alpha-hydroxylase, Cholesterol side-chain cleavage enzyme, Clinical trial, Cushing's syndrome, CYP17A1, Dextrorotation and levorotation, Efficacy, Enantiomer, Enzyme, Enzyme inhibitor, Glucocorticoid, Hepatotoxicity, International nonproprietary name, Ketoconazole, Lanosterol 14 alpha-demethylase, Metabolite, Oral administration, Osilodrostat, Pharmacovigilance, Potency (pharmacology), Racemic mixture, Steroid 11β-hydroxylase, Steroidogenesis inhibitor, United States Adopted Name, 21-Hydroxylase.
Bile acid
Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates.
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Biosynthesis
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
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Cholesterol 7 alpha-hydroxylase
Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded by the CYP7A1 gene which has an important role in cholesterol metabolism.
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Cholesterol side-chain cleavage enzyme
Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Cushing's syndrome
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to cortisol.
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CYP17A1
Cytochrome P450 17A1, also called steroid 17α-monooxygenase, 17α-hydroxylase, 17,20-lyase, or 17,20-desmolase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.
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Dextrorotation and levorotation
Dextrorotation and levorotation (also spelled as laevorotation)The first word component dextro- comes from Latin word for dexter "right (as opposed to left)".
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Efficacy
Efficacy is the ability to get a job done satisfactorily.
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Enantiomer
In chemistry, an enantiomer, also known as an optical isomer (and archaically termed antipode or optical antipode), is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).
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Enzyme
Enzymes are macromolecular biological catalysts.
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Enzyme inhibitor
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
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Glucocorticoid
Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.
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Hepatotoxicity
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Ketoconazole
Ketoconazole is a synthetic imidazole antifungal drug used primarily to treat fungal infections.
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Lanosterol 14 alpha-demethylase
Lanosterol 14α-demethylase (or CYP51A1) is a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol.
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Metabolite
A metabolite is the intermediate end product of metabolism.
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Oral administration
| name.
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Osilodrostat
Osilodrostat (INN, USAN) (developmental code name LCI-699) is an orally active, nonsteroidal corticosteroid biosynthesis inhibitor which is under development by Novartis for the treatment of Cushing's syndrome and adrenocorticotropic hormone hypersecretion (a specific subtype of Cushing's syndrome).
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Pharmacovigilance
Pharmacovigilance (PV or PhV), also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Steroid 11β-hydroxylase
Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata.
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Steroidogenesis inhibitor
A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved in the process of steroidogenesis, the biosynthesis of endogenous steroids and steroid hormones.
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United States Adopted Name
United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.
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21-Hydroxylase
Steroid 21-hydroxylase, also called steroid 21-monooxygenase, 21α-Hydroxylase, P450 21A2, and, less commonly 21β-Hydroxylase, is a cytochrome P450 enzyme that is involved with the biosynthesis of the steroid hormones aldosterone and cortisol.
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Redirects here:
(2S,4R)-Ketoconazole, (2S,4R)-ketoconazole, 2S,4R-Ketoconazole, 2S,4R-ketoconazole, COR 003, COR-003, COR003, Levo-Ketoconazole, Levo-ketoconazole, NormoCort, Normocort, Recorlev.
References
[1] https://en.wikipedia.org/wiki/Levoketoconazole
