95 relations: Active metabolite, Adrenergic antagonist, Adrenergic receptor, Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor, Amine, Amineptine, Amitriptyline, Anticholinergic, Antihistamine, Butriptyline, Cardiotoxicity, CAS Registry Number, Channel blocker, Chemical formula, Chemical nomenclature, Chemical structure, Chronic pain, CYP2D6, Desipramine, Dibenzocycloheptene, Dopamine receptor D2, Dopamine transporter, English language, Epileptic seizure, Feces, Free base, French language, German language, Glaucoma, Heart arrhythmia, Histamine H1 receptor, Histamine H2 receptor, Histamine H3 receptor, Histamine H4 receptor, Hydrochloride, Hypertensive crisis, Hyperthyroidism, Hypotension, Irritable bowel syndrome, Italian language, Latin, Liver, Major depressive disorder, Methylation, Migraine, Molecular mass, Monoamine oxidase inhibitor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, ..., Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Myocardial infarction, Neuralgia, Neuropathic pain, Nocturnal enuresis, Norepinephrine, Norepinephrine transporter, Norepinephrine–dopamine reuptake inhibitor, Novartis, Off-label use, Oral administration, Orthostatic hypotension, Panic disorder, Parent structure, Pharmacodynamics, Phenelzine, Protriptyline, Pseudobulbar affect, Reuptake, Ring (chemistry), Salt (chemistry), Sedation, Serotonin, Serotonin syndrome, Serotonin transporter, Side chain, Sigma-1 receptor, Sodium channel, Spanish language, Stroke, Suicidal ideation, Temporomandibular joint dysfunction, Trademark distinctiveness, Tricyclic, Tricyclic antidepressant, United Kingdom, Urine, Weight gain, 5-HT1A receptor, 5-HT2A receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT6 receptor. Expand index (45 more) » « Shrink index
An active metabolite is an active form of a drug after it has been processed by the body.
An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors.
The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.
Amineptine, sold under the brand name Survector among others, is an atypical antidepressant of the tricyclic antidepressant (TCA) family.
Amitriptyline, sold under the brand name Elavil among others, is a medicine primarily used to treat a number of mental illnesses.
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.
Antihistamines are drugs which treat allergic rhinitis and other allergies.
Butriptyline, sold under the brand name Evadyne among others, is a tricyclic antidepressant (TCA) that has been used in the United Kingdom and several other European countries for the treatment of depression but appears to no longer be marketed.
Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage.
A CAS Registry Number, also referred to as CASRN or CAS Number, is a unique numerical identifier assigned by the Chemical Abstracts Service (CAS) to every chemical substance described in the open scientific literature (currently including all substances described from 1957 through the present, plus some substances from the early or mid 1900s), including organic and inorganic compounds, minerals, isotopes, alloys and nonstructurable materials (UVCBs, of unknown, variable composition, or biological origin).
A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell.
A chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and plus (+) and minus (−) signs.
A chemical nomenclature is a set of rules to generate systematic names for chemical compounds.
A chemical structure determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid.
Chronic pain is pain that lasts a long time.
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
Desipramine, sold under the brand name Norpramin and Pertofrane among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression.
Dibenzocycloheptene, also known as dibenzocycloheptadiene or dibenzosuberane, is a tricyclic chemical compound featuring two benzene rings bound to a cycloheptene group.
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
English is a West Germanic language that was first spoken in early medieval England and is now a global lingua franca.
An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
Free base (freebase, free-base) is the conjugate base (deprotonated) form of an amine, as opposed to its conjugate acid (protonated) form.
French (le français or la langue française) is a Romance language of the Indo-European family.
German (Deutsch) is a West Germanic language that is mainly spoken in Central Europe.
Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.
Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
H2 receptors are positively coupled to adenylate cyclase via Gs.
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release.
The histamine H4 receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily.
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).
Severely elevated blood pressure (equal to or greater than a systolic 180 or diastolic of 110—sometimes termed malignant or accelerated hypertension) is referred to as a hypertensive crisis, as blood pressure at this level confers a high risk of complications.
Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland.
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
Irritable bowel syndrome (IBS) is a group of symptoms—including abdominal pain and changes in the pattern of bowel movements without any evidence of underlying damage.
Italian (or lingua italiana) is a Romance language.
Latin (Latin: lingua latīna) is a classical language belonging to the Italic branch of the Indo-European languages.
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.
A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe.
Relative Molecular mass or molecular weight is the mass of a molecule.
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.
The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.
The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.
The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
Neuralgia (Greek neuron, "nerve" + algos, "pain") is pain in the distribution of a nerve or nerves, as in intercostal neuralgia, trigeminal neuralgia, and glossopharyngeal neuralgia.
Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system.
Nocturnal enuresis, also called bedwetting, is involuntary urination while asleep after the age at which bladder control usually occurs.
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
A norepinephrine–dopamine reuptake inhibitor (NDRI) is a drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively.
Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland.
Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.
Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position.
Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks.
In IUPAC nomenclature, a parent structure, parent compound, parent name or simply parent is the denotation for a compound consisting of an unbranched chain of skeletal atoms (not necessarily carbon), or consisting of an unsubstituted monocyclic or polycyclic ring system.
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
Phenelzine (Nardil, Nardelzine) is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class which is used as an antidepressant and anxiolytic.
Protriptyline, sold under the brand name Vivactil among others, is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for the treatment of depression and attention-deficit hyperactivity disorder (ADHD).
Pseudobulbar affect (PBA), or emotional incontinence, is a type of emotional disturbance characterized by uncontrollable episodes of crying and/or laughing, or other emotional displays.
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.
In chemistry, a ring is an ambiguous term referring either to a simple cycle of atoms and bonds in a molecule or to a connected set of atoms and bonds in which every atom and bond is a member of a cycle (also called a ring system).
In chemistry, a salt is an ionic compound that can be formed by the neutralization reaction of an acid and a base.
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs.
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called "main chain" or backbone.
The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
Spanish or Castilian, is a Western Romance language that originated in the Castile region of Spain and today has hundreds of millions of native speakers in Latin America and Spain.
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
Suicidal ideation, also known as suicidal thoughts, is thinking about or having an unusual preoccupation with suicide.
Temporomandibular joint dysfunction (TMD, TMJD) is an umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).
Trademark distinctiveness is an important concept in the law governing trademarks and service marks.
Tricyclics are chemical compounds that contain three interconnected rings of atoms.
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.
Urine is a liquid by-product of metabolism in humans and in many animals.
Weight gain is an increase in body weight.
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).
ATC code N06AA10, ATCvet code QN06AA10, AVENTYL HCL, Acetexa, Allegron, Altilev, Amitryptyline, Demethyl-, Ateben, Avantyl, Aventil, Aventyl, Demethylamitriptylene, Demethylamitriptyline, Demethylamitryptyline, Desitriptilina, Desitriptyline, Desmethylamitriptyline, E.L.F. 101, E.L.F.-101, E.L.F.101, ELF 101, ELF-101, ELF101, Lumbeck, N 7048, N-7048, N7048, Noramitriptyline, Noritren, Norpress, Nortrilen, Nortriptilina, Nortriptylin, Nortriptylina, Nortriptyline Hydrochloride, Nortriptyline hydrochloride, Nortriptylinum, Nortryptiline, Nortryptyline, Norventyl, Norzepine, PAMELOR, Pamelor, Psychostyl, Sensaval, Sensival Ventyl, Sensoval, Sesaval, Vividyl.