42 relations: AKT1, Apoptosis, Bcl-2, Binding site, Cell cycle, Chicken ovalbumin upstream promoter-transcription factor, Conserved sequence, DNA-binding domain, Exon, Experimental & Molecular Medicine, Gene, HIF1A, Homology (biology), Human, Human Genome Organisation, Immediate early gene, Inflammation, Intracellular, Intron, Macrophage, Metastasis, Monomer, Mouse, Neuron-derived orphan receptor 1, NF-κB, Nuclear receptor, Nuclear receptor co-repressor 2, Nuclear receptor related-1 protein, Nur (biology), Promyelocytic leukemia protein, Protein, Protein dimer, Protein–protein interaction, Rat, Response element, Retinoid, Retinoid X receptor, Retinoid X receptor alpha, Sequence motif, Transactivation, Transcription factor, Von Hippel–Lindau tumor suppressor.
AKT1
RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Bcl-2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.
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Binding site
In biochemistry, a binding site is a region on a protein or piece of DNA or RNA to which ligands (specific molecules and/or ions) may form a chemical bond.
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Cell cycle
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.
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Chicken ovalbumin upstream promoter-transcription factor
The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of intracellular transcription factors.
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Conserved sequence
In evolutionary biology, conserved sequences are similar or identical sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences) or within a genome (paralogous sequences).
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DNA-binding domain
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Experimental & Molecular Medicine
Experimental & Molecular Medicine is a monthly peer-reviewed open access medical journal covering biochemistry and molecular biology.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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HIF1A
Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene.
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Homology (biology)
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
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Human
Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.
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Human Genome Organisation
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome.
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Immediate early gene
Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Intracellular
In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".
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Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Metastasis
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor.
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Monomer
A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".
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Mouse
A mouse (Mus), plural mice, is a small rodent characteristically having a pointed snout, small rounded ears, a body-length scaly tail and a high breeding rate.
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Neuron-derived orphan receptor 1
The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3 gene.
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NF-κB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
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Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
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Nuclear receptor co-repressor 2
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains.
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Nuclear receptor related-1 protein
The Nuclear receptor related 1 protein (NURR1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene.
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Nur (biology)
Nur (nuclear receptor subfamily 4) is a family of orphan nuclear receptors which act as transcription factors in neuron development and maintenance.
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Promyelocytic leukemia protein
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Rat
Rats are various medium-sized, long-tailed rodents in the superfamily Muroidea.
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Response element
Response elements are short sequences of DNA within a gene promoter region that are able to bind specific transcription factors and regulate transcription of genes.
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Retinoid
The retinoids are a class of chemical compounds that are vitamers of vitamin A or are chemically related to it.
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Retinoid X receptor
The retinoid X receptor (RXR) is a type of nuclear receptor that is activated by 9-cis retinoic acid, which is discussed controversially to be of endogenous relevance, and 9-cis-13,14-dihydro-retinoic acid, which is likely to be the major endogenous mammalian RXR-selective agonist.
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Retinoid X receptor alpha
Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.
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Sequence motif
In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.
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Transactivation
In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.
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Transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
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Von Hippel–Lindau tumor suppressor
The von Hippel–Lindau tumor suppressor also known as pVHL is a protein that in humans is encoded by the VHL gene.
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References
[1] https://en.wikipedia.org/wiki/Nerve_growth_factor_IB