Logo
Unionpedia
Communication
Get it on Google Play
New! Download Unionpedia on your Android™ device!
Free
Faster access than browser!
 

Nuclear receptor

Index Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. [1]

183 relations: Active transport, Adolf Butenandt, Afimoxifene, Agonist, Albert Lasker Award for Basic Medical Research, Aldosterone, Algae, Alpha helix, Amphimedon queenslandica, Androgen receptor, Androstane, Animal, Anti-inflammatory, Biomolecular structure, Björn Vennström, C-terminus, Caenorhabditis elegans, Calcitriol receptor, Cell nucleus, Chicken ovalbumin upstream promoter-transcription factor, Cholesterol, Chromatin, Cnidaria, Coactivation (Transcription), Coactivator (genetics), Conformational isomerism, Constitutive androstane receptor, Coordination complex, Corepressor, Cortisol, Cortisone, COUP-TFI, COUP-TFII, Ctenophora, Cytochrome P450, Cytoplasm, Cytosol, DAX1, Developmental biology, Dexamethasone, Dissociation (chemistry), DNA, DNA-binding domain, Edward Adelbert Doisy, Edward Calvin Kendall, Elwood V. Jensen, Endocrine disruptor, Endogeny (biology), Ernest Starling, Estradiol, ..., Estrogen, Estrogen receptor, Estrogen receptor alpha, Estrogen receptor beta, Estrogen-related receptor, Estrogen-related receptor alpha, Estrogen-related receptor beta, Estrogen-related receptor gamma, Farnesoid X receptor, Fatty acid, Food and Drug Administration, Fungus, Gene, Gene expression, Genomics, Germ cell nuclear factor, Glucocorticoid, Glucocorticoid receptor, Heat shock protein, Heme, Hepatocyte nuclear factor 4, Hepatocyte nuclear factor 4 alpha, Hepatocyte nuclear factor 4 gamma, Hippocampus, Histone, Histone acetyltransferase, Histone deacetylase, Hormone, Hormone response element, Intracellular receptor, Inverse agonist, Inverted repeat, Ligand (biochemistry), Lipophilicity, Liver receptor homolog-1, Liver X receptor, Liver X receptor alpha, Liver X receptor beta, Messenger RNA, Mifepristone, Mineralocorticoid receptor, Mnemiopsis, Molecular biology, Molecular mass, N-terminus, Nematode, Nerve growth factor IB, Neuron-derived orphan receptor 1, Nobel Prize in Physiology or Medicine, Nuclear receptor coactivator 2, Nuclear receptor related-1 protein, NucleaRDB, Obesogen, Orphan receptor, Peroxisome proliferator-activated receptor, Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor delta, Peroxisome proliferator-activated receptor gamma, Phenylalanine, Phosphatidylinositol, Phosphoinositide 3-kinase, Photoreceptor cell-specific nuclear receptor, Pierre Chambon, Placozoa, Pregnane X receptor, Progesterone, Progesterone receptor, Prostaglandin, Protein, Protein dimer, Protein domain, Protein folding, Protein targeting, Protist, RAR-related orphan receptor, RAR-related orphan receptor alpha, RAR-related orphan receptor beta, RAR-related orphan receptor gamma, Receptor (biochemistry), Retinoic acid, Retinoic acid receptor, Retinoic acid receptor alpha, Retinoic acid receptor beta, Retinoic acid receptor gamma, Retinoid, Retinoid X receptor, Retinoid X receptor alpha, Retinoid X receptor beta, Retinoid X receptor gamma, Rev-ErbA, Rev-ErbA alpha, Rev-ErbA beta, RNA polymerase, Ronald M. Evans, Selective androgen receptor modulator, Selective estrogen receptor modulator, Selective glucocorticoid receptor modulator, Selective progesterone receptor modulator, Signal transduction, Small heterodimer partner, Space-filling model, Sponge, Starlet sea anemone, Steric effects, Steroid hormone, Steroid hormone receptor, Steroidogenic factor 1, Sterol, Synapse, Tadeusz Reichstein, Testicular receptor, Testicular receptor 2, Testicular receptor 4, Testosterone, Thyroid hormone receptor, Thyroid hormone receptor alpha, Thyroid hormone receptor beta, Thyroid hormones, TLX, Transactivation, Transcription (biology), Transcription coregulator, Transcription factor, Transrepression, Tretinoin, Trichoplax, Tyrosine, Unified atomic mass unit, V-erbA-related gene, Vitamin A, Vitamin D, Xenobiotic, Zinc finger. Expand index (133 more) »

Active transport

Active transport is the movement of molecules across a membrane from a region of their lower concentration to a region of their higher concentration—in the direction against the concentration gradient.

New!!: Nuclear receptor and Active transport · See more »

Adolf Butenandt

Adolf Friedrich Johann Butenandt (24 March 1903 – 18 January 1995) was a German biochemist.

New!!: Nuclear receptor and Adolf Butenandt · See more »

Afimoxifene

Afimoxifene, also known as 4-hydroxytamoxifen (4-OHT, 4-HT, OHTAM, others), is a selective estrogen receptor modulator (SERM) of the triphenylethylene group and the major active metabolite of tamoxifen.

New!!: Nuclear receptor and Afimoxifene · See more »

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

New!!: Nuclear receptor and Agonist · See more »

Albert Lasker Award for Basic Medical Research

The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for the outstanding discovery, Contribution and achievement in the field of medicine and Human Physiology.

New!!: Nuclear receptor and Albert Lasker Award for Basic Medical Research · See more »

Aldosterone

Aldosterone, the main mineralocorticoid hormone, is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland.

New!!: Nuclear receptor and Aldosterone · See more »

Algae

Algae (singular alga) is an informal term for a large, diverse group of photosynthetic organisms that are not necessarily closely related, and is thus polyphyletic.

New!!: Nuclear receptor and Algae · See more »

Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

New!!: Nuclear receptor and Alpha helix · See more »

Amphimedon queenslandica

Amphimedon queenslandica (formerly known as Reniera sp.) is a sponge native to the Great Barrier Reef.

New!!: Nuclear receptor and Amphimedon queenslandica · See more »

Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.

New!!: Nuclear receptor and Androgen receptor · See more »

Androstane

Androstane is a C19 steroid with a gonane core.

New!!: Nuclear receptor and Androstane · See more »

Animal

Animals are multicellular eukaryotic organisms that form the biological kingdom Animalia.

New!!: Nuclear receptor and Animal · See more »

Anti-inflammatory

Anti-inflammatory, or antiinflammatory, refers to the property of a substance or treatment that reduces inflammation or swelling.

New!!: Nuclear receptor and Anti-inflammatory · See more »

Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

New!!: Nuclear receptor and Biomolecular structure · See more »

Björn Vennström

Björn Vennström (born 1948) is a Swedish molecular biologist.

New!!: Nuclear receptor and Björn Vennström · See more »

C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

New!!: Nuclear receptor and C-terminus · See more »

Caenorhabditis elegans

Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.

New!!: Nuclear receptor and Caenorhabditis elegans · See more »

Calcitriol receptor

The calcitriol receptor, more commonly known as the vitamin D receptor (VDR) and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors.

New!!: Nuclear receptor and Calcitriol receptor · See more »

Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

New!!: Nuclear receptor and Cell nucleus · See more »

Chicken ovalbumin upstream promoter-transcription factor

The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of intracellular transcription factors.

New!!: Nuclear receptor and Chicken ovalbumin upstream promoter-transcription factor · See more »

Cholesterol

Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.

New!!: Nuclear receptor and Cholesterol · See more »

Chromatin

Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.

New!!: Nuclear receptor and Chromatin · See more »

Cnidaria

Cnidaria is a phylum containing over 10,000 species of animals found exclusively in aquatic (freshwater and marine) environments: they are predominantly marine species.

New!!: Nuclear receptor and Cnidaria · See more »

Coactivation (Transcription)

Coactivation is a process by which the transcription of RNA is increased.

New!!: Nuclear receptor and Coactivation (Transcription) · See more »

Coactivator (genetics)

A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.

New!!: Nuclear receptor and Coactivator (genetics) · See more »

Conformational isomerism

In chemistry, conformational isomerism is a form of stereoisomerism in which the isomers can be interconverted just by rotations about formally single bonds (refer to figure on single bond rotation).

New!!: Nuclear receptor and Conformational isomerism · See more »

Constitutive androstane receptor

The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene.

New!!: Nuclear receptor and Constitutive androstane receptor · See more »

Coordination complex

In chemistry, a coordination complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents.

New!!: Nuclear receptor and Coordination complex · See more »

Corepressor

In the field of molecular biology, a corepressor is a substance that inhibits the expression of genes.

New!!: Nuclear receptor and Corepressor · See more »

Cortisol

Cortisol is a steroid hormone, in the glucocorticoid class of hormones.

New!!: Nuclear receptor and Cortisol · See more »

Cortisone

Cortisone, also known as 17α,21-dihydroxypregn-4-ene-3,11,20-trione, is a pregnane (21-carbon) steroid hormone.

New!!: Nuclear receptor and Cortisone · See more »

COUP-TFI

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.

New!!: Nuclear receptor and COUP-TFI · See more »

COUP-TFII

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.

New!!: Nuclear receptor and COUP-TFII · See more »

Ctenophora

Ctenophora (singular ctenophore, or; from the Greek κτείς kteis 'comb' and φέρω pherō 'to carry'; commonly known as comb jellies) is a phylum of invertebrate animals that live in marine waters worldwide.

New!!: Nuclear receptor and Ctenophora · See more »

Cytochrome P450

Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.

New!!: Nuclear receptor and Cytochrome P450 · See more »

Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

New!!: Nuclear receptor and Cytoplasm · See more »

Cytosol

The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

New!!: Nuclear receptor and Cytosol · See more »

DAX1

DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is a nuclear receptor protein that in humans is encoded by the NR0B1 gene (nuclear receptor subfamily 0, group B, member 1).

New!!: Nuclear receptor and DAX1 · See more »

Developmental biology

Developmental biology is the study of the process by which animals and plants grow and develop.

New!!: Nuclear receptor and Developmental biology · See more »

Dexamethasone

Dexamethasone is a type of corticosteroid medication.

New!!: Nuclear receptor and Dexamethasone · See more »

Dissociation (chemistry)

Dissociation in chemistry and biochemistry is a general process in which molecules (or ionic compounds such as salts, or complexes) separate or split into smaller particles such as atoms, ions or radicals, usually in a reversible manner.

New!!: Nuclear receptor and Dissociation (chemistry) · See more »

DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

New!!: Nuclear receptor and DNA · See more »

DNA-binding domain

A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.

New!!: Nuclear receptor and DNA-binding domain · See more »

Edward Adelbert Doisy

Edward Adelbert Doisy (November 13, 1893 – October 23, 1986) was an American biochemist.

New!!: Nuclear receptor and Edward Adelbert Doisy · See more »

Edward Calvin Kendall

Edward Calvin Kendall (March 8, 1886 – May 4, 1972) was an American chemist.

New!!: Nuclear receptor and Edward Calvin Kendall · See more »

Elwood V. Jensen

Elwood Vernon Jensen (January 13, 1920 – December 16, 2012) was the Distinguished University Professor, George and Elizabeth Wile Chair in Cancer Research at the University of Cincinnati College of Medicine's Vontz Center for Molecular Studies.

New!!: Nuclear receptor and Elwood V. Jensen · See more »

Endocrine disruptor

Endocrine disruptors are chemicals that can interfere with endocrine (or hormone) systems at certain doses.

New!!: Nuclear receptor and Endocrine disruptor · See more »

Endogeny (biology)

Endogenous substances and processes are those that originate from within an organism, tissue, or cell.

New!!: Nuclear receptor and Endogeny (biology) · See more »

Ernest Starling

Ernest Henry Starling (17 April 1866 – 2 May 1927) was a British physiologist who contributed many fundamental ideas to this subject.

New!!: Nuclear receptor and Ernest Starling · See more »

Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.

New!!: Nuclear receptor and Estradiol · See more »

Estrogen

Estrogen, or oestrogen, is the primary female sex hormone.

New!!: Nuclear receptor and Estrogen · See more »

Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

New!!: Nuclear receptor and Estrogen receptor · See more »

Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.

New!!: Nuclear receptor and Estrogen receptor alpha · See more »

Estrogen receptor beta

Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is one of two main types of estrogen receptor, a nuclear receptor which is activated by the sex hormone estrogen.

New!!: Nuclear receptor and Estrogen receptor beta · See more »

Estrogen-related receptor

The ERRs are orphan nuclear receptors, meaning the identity of their endogenous ligand has yet to be unambiguously determined.

New!!: Nuclear receptor and Estrogen-related receptor · See more »

Estrogen-related receptor alpha

Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene.

New!!: Nuclear receptor and Estrogen-related receptor alpha · See more »

Estrogen-related receptor beta

Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene.

New!!: Nuclear receptor and Estrogen-related receptor beta · See more »

Estrogen-related receptor gamma

Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene.

New!!: Nuclear receptor and Estrogen-related receptor gamma · See more »

Farnesoid X receptor

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.

New!!: Nuclear receptor and Farnesoid X receptor · See more »

Fatty acid

In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with a long aliphatic chain, which is either saturated or unsaturated.

New!!: Nuclear receptor and Fatty acid · See more »

Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

New!!: Nuclear receptor and Food and Drug Administration · See more »

Fungus

A fungus (plural: fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms.

New!!: Nuclear receptor and Fungus · See more »

Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: Nuclear receptor and Gene · See more »

Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.

New!!: Nuclear receptor and Gene expression · See more »

Genomics

Genomics is an interdisciplinary field of science focusing on the structure, function, evolution, mapping, and editing of genomes.

New!!: Nuclear receptor and Genomics · See more »

Germ cell nuclear factor

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene.

New!!: Nuclear receptor and Germ cell nuclear factor · See more »

Glucocorticoid

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.

New!!: Nuclear receptor and Glucocorticoid · See more »

Glucocorticoid receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.

New!!: Nuclear receptor and Glucocorticoid receptor · See more »

Heat shock protein

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions.

New!!: Nuclear receptor and Heat shock protein · See more »

Heme

Heme or haem is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands.

New!!: Nuclear receptor and Heme · See more »

Hepatocyte nuclear factor 4

HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical for liver development.

New!!: Nuclear receptor and Hepatocyte nuclear factor 4 · See more »

Hepatocyte nuclear factor 4 alpha

Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is encoded by the HNF4A gene.

New!!: Nuclear receptor and Hepatocyte nuclear factor 4 alpha · See more »

Hepatocyte nuclear factor 4 gamma

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4G gene.

New!!: Nuclear receptor and Hepatocyte nuclear factor 4 gamma · See more »

Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

New!!: Nuclear receptor and Hippocampus · See more »

Histone

In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes.

New!!: Nuclear receptor and Histone · See more »

Histone acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine.

New!!: Nuclear receptor and Histone acetyltransferase · See more »

Histone deacetylase

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O.

New!!: Nuclear receptor and Histone deacetylase · See more »

Hormone

A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

New!!: Nuclear receptor and Hormone · See more »

Hormone response element

A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind to a specific hormone receptor complex and therefore regulate transcription.

New!!: Nuclear receptor and Hormone response element · See more »

Intracellular receptor

Intracellular receptors are receptors located inside the cell rather than on its cell membrane.

New!!: Nuclear receptor and Intracellular receptor · See more »

Inverse agonist

In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.

New!!: Nuclear receptor and Inverse agonist · See more »

Inverted repeat

An inverted repeat (or IR) is a single stranded sequence of nucleotides followed downstream by its reverse complement.

New!!: Nuclear receptor and Inverted repeat · See more »

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

New!!: Nuclear receptor and Ligand (biochemistry) · See more »

Lipophilicity

Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.

New!!: Nuclear receptor and Lipophilicity · See more »

Liver receptor homolog-1

The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.

New!!: Nuclear receptor and Liver receptor homolog-1 · See more »

Liver X receptor

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR.

New!!: Nuclear receptor and Liver X receptor · See more »

Liver X receptor alpha

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).

New!!: Nuclear receptor and Liver X receptor alpha · See more »

Liver X receptor beta

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors.

New!!: Nuclear receptor and Liver X receptor beta · See more »

Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

New!!: Nuclear receptor and Messenger RNA · See more »

Mifepristone

Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol, to bring about an abortion.

New!!: Nuclear receptor and Mifepristone · See more »

Mineralocorticoid receptor

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.

New!!: Nuclear receptor and Mineralocorticoid receptor · See more »

Mnemiopsis

Mnemiopsis leidyi, the warty comb jelly or sea walnut, is a species of tentaculate ctenophore (comb jelly), originally native to the western Atlantic coastal waters.

New!!: Nuclear receptor and Mnemiopsis · See more »

Molecular biology

Molecular biology is a branch of biology which concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions.

New!!: Nuclear receptor and Molecular biology · See more »

Molecular mass

Relative Molecular mass or molecular weight is the mass of a molecule.

New!!: Nuclear receptor and Molecular mass · See more »

N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

New!!: Nuclear receptor and N-terminus · See more »

Nematode

The nematodes or roundworms constitute the phylum Nematoda (also called Nemathelminthes).

New!!: Nuclear receptor and Nematode · See more »

Nerve growth factor IB

The nerve growth factor IB (NGFIB) also known as Nur77 or NR4A1 (nuclear receptor subfamily 4 group A member 1) is a protein that in humans is encoded by the NR4A1 gene.

New!!: Nuclear receptor and Nerve growth factor IB · See more »

Neuron-derived orphan receptor 1

The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3 gene.

New!!: Nuclear receptor and Neuron-derived orphan receptor 1 · See more »

Nobel Prize in Physiology or Medicine

The Nobel Prize in Physiology or Medicine (Nobelpriset i fysiologi eller medicin), administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the fields of life sciences and medicine.

New!!: Nuclear receptor and Nobel Prize in Physiology or Medicine · See more »

Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene.

New!!: Nuclear receptor and Nuclear receptor coactivator 2 · See more »

Nuclear receptor related-1 protein

The Nuclear receptor related 1 protein (NURR1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene.

New!!: Nuclear receptor and Nuclear receptor related-1 protein · See more »

NucleaRDB

The NucleaRDB is a database of nuclear receptors.

New!!: Nuclear receptor and NucleaRDB · See more »

Obesogen

Obesogens are foreign chemical compounds that disrupt normal development and balance of lipid metabolism, which in some cases, can lead to obesity.

New!!: Nuclear receptor and Obesogen · See more »

Orphan receptor

In biochemistry, an orphan receptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified.

New!!: Nuclear receptor and Orphan receptor · See more »

Peroxisome proliferator-activated receptor

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes.

New!!: Nuclear receptor and Peroxisome proliferator-activated receptor · See more »

Peroxisome proliferator-activated receptor alpha

Peroxisome proliferator-activated receptor alpha (PPAR-alpha), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein that in humans is encoded by the PPARA gene.

New!!: Nuclear receptor and Peroxisome proliferator-activated receptor alpha · See more »

Peroxisome proliferator-activated receptor delta

Peroxisome proliferator-activated receptor beta or delta (PPAR-β or PPAR-δ), also known as NR1C2 (nuclear receptor subfamily 1, group C, member 2) is a nuclear receptor that in humans is encoded by the PPARD gene.

New!!: Nuclear receptor and Peroxisome proliferator-activated receptor delta · See more »

Peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor that in humans is encoded by the PPARG gene.

New!!: Nuclear receptor and Peroxisome proliferator-activated receptor gamma · See more »

Phenylalanine

Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.

New!!: Nuclear receptor and Phenylalanine · See more »

Phosphatidylinositol

Phosphatidylinositol consists of a family of lipids as illustrated on the right, a class of the phosphatidylglycerides.

New!!: Nuclear receptor and Phosphatidylinositol · See more »

Phosphoinositide 3-kinase

Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

New!!: Nuclear receptor and Phosphoinositide 3-kinase · See more »

Photoreceptor cell-specific nuclear receptor

The photoreceptor cell-specific nuclear receptor (PNR), also known as NR2E3 (nuclear receptor subfamily 2, group E, member 3), is a protein that in humans is encoded by the NR2E3 gene.

New!!: Nuclear receptor and Photoreceptor cell-specific nuclear receptor · See more »

Pierre Chambon

Pierre Chambon (born 7 February 1931, Mulhouse, France) was the founder of the in Strasbourg, France.

New!!: Nuclear receptor and Pierre Chambon · See more »

Placozoa

The Placozoa are a basal form of free-living (non-parasitic) multicellular organism.

New!!: Nuclear receptor and Placozoa · See more »

Pregnane X receptor

In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene.

New!!: Nuclear receptor and Pregnane X receptor · See more »

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

New!!: Nuclear receptor and Progesterone · See more »

Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

New!!: Nuclear receptor and Progesterone receptor · See more »

Prostaglandin

The prostaglandins (PG) are a group of physiologically active lipid compounds having diverse hormone-like effects in animals.

New!!: Nuclear receptor and Prostaglandin · See more »

Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

New!!: Nuclear receptor and Protein · See more »

Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

New!!: Nuclear receptor and Protein dimer · See more »

Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

New!!: Nuclear receptor and Protein domain · See more »

Protein folding

Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.

New!!: Nuclear receptor and Protein folding · See more »

Protein targeting

Protein targeting or protein sorting is the biological mechanism by which proteins are transported to the appropriate destinations in the cell or outside it.

New!!: Nuclear receptor and Protein targeting · See more »

Protist

A protist is any eukaryotic organism that has cells with nuclei and is not an animal, plant or fungus.

New!!: Nuclear receptor and Protist · See more »

RAR-related orphan receptor

The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors.

New!!: Nuclear receptor and RAR-related orphan receptor · See more »

RAR-related orphan receptor alpha

RAR-related orphan receptor alpha (RORα), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor that in humans is encoded by the RORA gene.

New!!: Nuclear receptor and RAR-related orphan receptor alpha · See more »

RAR-related orphan receptor beta

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.

New!!: Nuclear receptor and RAR-related orphan receptor beta · See more »

RAR-related orphan receptor gamma

RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene.

New!!: Nuclear receptor and RAR-related orphan receptor gamma · See more »

Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

New!!: Nuclear receptor and Receptor (biochemistry) · See more »

Retinoic acid

Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development.

New!!: Nuclear receptor and Retinoic acid · See more »

Retinoic acid receptor

The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid.

New!!: Nuclear receptor and Retinoic acid receptor · See more »

Retinoic acid receptor alpha

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor that in humans is encoded by the RARA gene.

New!!: Nuclear receptor and Retinoic acid receptor alpha · See more »

Retinoic acid receptor beta

Retinoic acid receptor beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor that in humans is encoded by the RARB gene.

New!!: Nuclear receptor and Retinoic acid receptor beta · See more »

Retinoic acid receptor gamma

Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.

New!!: Nuclear receptor and Retinoic acid receptor gamma · See more »

Retinoid

The retinoids are a class of chemical compounds that are vitamers of vitamin A or are chemically related to it.

New!!: Nuclear receptor and Retinoid · See more »

Retinoid X receptor

The retinoid X receptor (RXR) is a type of nuclear receptor that is activated by 9-cis retinoic acid, which is discussed controversially to be of endogenous relevance, and 9-cis-13,14-dihydro-retinoic acid, which is likely to be the major endogenous mammalian RXR-selective agonist.

New!!: Nuclear receptor and Retinoid X receptor · See more »

Retinoid X receptor alpha

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.

New!!: Nuclear receptor and Retinoid X receptor alpha · See more »

Retinoid X receptor beta

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.

New!!: Nuclear receptor and Retinoid X receptor beta · See more »

Retinoid X receptor gamma

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.

New!!: Nuclear receptor and Retinoid X receptor gamma · See more »

Rev-ErbA

The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors.

New!!: Nuclear receptor and Rev-ErbA · See more »

Rev-ErbA alpha

Rev-ErbA alpha also known as NR1D1 (nuclear receptor subfamily 1, group D, member 1), is a protein that in humans is encoded by the NR1D1 gene.

New!!: Nuclear receptor and Rev-ErbA alpha · See more »

Rev-ErbA beta

Rev-ErbA beta (Rev-erbβ) also known as NR1D2 (nuclear receptor subfamily 1, group D, member 2) is a protein that in humans is encoded by the NR1D2 gene.

New!!: Nuclear receptor and Rev-ErbA beta · See more »

RNA polymerase

RNA polymerase (ribonucleic acid polymerase), both abbreviated RNAP or RNApol, official name DNA-directed RNA polymerase, is a member of a family of enzymes that are essential to life: they are found in all organisms (-species) and many viruses.

New!!: Nuclear receptor and RNA polymerase · See more »

Ronald M. Evans

Ronald Mark Evans (born April 17, 1949 in Los Angeles) is an American professor and biologist at the Salk Institute for Biological Studies in La Jolla, California and a Howard Hughes Medical Institute Investigator.

New!!: Nuclear receptor and Ronald M. Evans · See more »

Selective androgen receptor modulator

Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands.

New!!: Nuclear receptor and Selective androgen receptor modulator · See more »

Selective estrogen receptor modulator

Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).

New!!: Nuclear receptor and Selective estrogen receptor modulator · See more »

Selective glucocorticoid receptor modulator

Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as dissociated glucocorticoid receptor agonists (DIGRAs) are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer properties of classical glucocorticoid drugs but with fewer side effects such as skin atrophy.

New!!: Nuclear receptor and Selective glucocorticoid receptor modulator · See more »

Selective progesterone receptor modulator

A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor.

New!!: Nuclear receptor and Selective progesterone receptor modulator · See more »

Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

New!!: Nuclear receptor and Signal transduction · See more »

Small heterodimer partner

The small heterodimer partner (SHP) also known as NR0B2 (nuclear receptor subfamily 0, group B, member 2) is a protein that in humans is encoded by the NR0B2 gene.

New!!: Nuclear receptor and Small heterodimer partner · See more »

Space-filling model

In chemistry, a space-filling model, also known as a calotte model, is a type of three-dimensional (3D) molecular model where the atoms are represented by spheres whose radii are proportional to the radii of the atoms and whose center-to-center distances are proportional to the distances between the atomic nuclei, all in the same scale.

New!!: Nuclear receptor and Space-filling model · See more »

Sponge

Sponges, the members of the phylum Porifera (meaning "pore bearer"), are a basal Metazoa clade as sister of the Diploblasts.

New!!: Nuclear receptor and Sponge · See more »

Starlet sea anemone

The starlet sea anemone (Nematostella vectensis) is a species of small sea anemone in the family Edwardsiidae native to the east coast of the United States, with introduced populations along the coast of southeast England and the west coast of the United States.

New!!: Nuclear receptor and Starlet sea anemone · See more »

Steric effects

Steric effects are nonbonding interactions that influence the shape (conformation) and reactivity of ions and molecules.

New!!: Nuclear receptor and Steric effects · See more »

Steroid hormone

A steroid hormone is a steroid that acts as a hormone.

New!!: Nuclear receptor and Steroid hormone · See more »

Steroid hormone receptor

Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells.

New!!: Nuclear receptor and Steroid hormone receptor · See more »

Steroidogenic factor 1

The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling activity of genes related to the reproductive glands or gonads and adrenal glands.

New!!: Nuclear receptor and Steroidogenic factor 1 · See more »

Sterol

Sterols, also known as steroid alcohols, are a subgroup of the steroids and an important class of organic molecules.

New!!: Nuclear receptor and Sterol · See more »

Synapse

In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target efferent cell.

New!!: Nuclear receptor and Synapse · See more »

Tadeusz Reichstein

Tadeusz Reichstein (20 July 1897 – 1 August 1996) was a Polish-Swiss chemist and the Nobel Prize in Physiology or Medicine laureate (1950).

New!!: Nuclear receptor and Tadeusz Reichstein · See more »

Testicular receptor

The testicular receptor proteins are members of the nuclear receptor family of intracellular transcription factors.

New!!: Nuclear receptor and Testicular receptor · See more »

Testicular receptor 2

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.

New!!: Nuclear receptor and Testicular receptor 2 · See more »

Testicular receptor 4

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.

New!!: Nuclear receptor and Testicular receptor 4 · See more »

Testosterone

Testosterone is the primary male sex hormone and an anabolic steroid.

New!!: Nuclear receptor and Testosterone · See more »

Thyroid hormone receptor

The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone.

New!!: Nuclear receptor and Thyroid hormone receptor · See more »

Thyroid hormone receptor alpha

Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene.

New!!: Nuclear receptor and Thyroid hormone receptor alpha · See more »

Thyroid hormone receptor beta

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.

New!!: Nuclear receptor and Thyroid hormone receptor beta · See more »

Thyroid hormones

Thyroid hormones are two hormones produced and released by the thyroid gland, namely triiodothyronine (T3) and thyroxine (T4).

New!!: Nuclear receptor and Thyroid hormones · See more »

TLX

Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E member 1) is a protein that in humans is encoded by the NR2E1 gene.

New!!: Nuclear receptor and TLX · See more »

Transactivation

In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.

New!!: Nuclear receptor and Transactivation · See more »

Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

New!!: Nuclear receptor and Transcription (biology) · See more »

Transcription coregulator

In molecular biology and genetics, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes.

New!!: Nuclear receptor and Transcription coregulator · See more »

Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

New!!: Nuclear receptor and Transcription factor · See more »

Transrepression

In the field of molecular biology, transrepression is a process whereby one protein represses (i.e., inhibits) the activity of a second protein through a protein-protein interaction.

New!!: Nuclear receptor and Transrepression · See more »

Tretinoin

Tretinoin, also known as all-trans retinoic acid (ATRA), is medication used for the treatment of acne and acute promyelocytic leukemia.

New!!: Nuclear receptor and Tretinoin · See more »

Trichoplax

Trichoplax adhaerens is the only extant representative of phylum Placozoa, which is a basal group of multicellular animals (metazoa).

New!!: Nuclear receptor and Trichoplax · See more »

Tyrosine

Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.

New!!: Nuclear receptor and Tyrosine · See more »

Unified atomic mass unit

The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).

New!!: Nuclear receptor and Unified atomic mass unit · See more »

V-erbA-related gene

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.

New!!: Nuclear receptor and V-erbA-related gene · See more »

Vitamin A

Vitamin A is a group of unsaturated nutritional organic compounds that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids (most notably beta-carotene).

New!!: Nuclear receptor and Vitamin A · See more »

Vitamin D

Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects.

New!!: Nuclear receptor and Vitamin D · See more »

Xenobiotic

A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism.

New!!: Nuclear receptor and Xenobiotic · See more »

Zinc finger

A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold.

New!!: Nuclear receptor and Zinc finger · See more »

Redirects here:

Ligand binding domain, Ligand-binding domain, Nuclear hormone receptor, Nuclear hormone receptor class, Nuclear receptors.

References

[1] https://en.wikipedia.org/wiki/Nuclear_receptor

OutgoingIncoming
Hey! We are on Facebook now! »