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Oligosaccharyltransferase

Index Oligosaccharyltransferase

Oligosaccharyltransferase or OST is a membrane protein complex that transfers a 14-sugar oligosaccharide from dolichol to nascent protein. [1]

32 relations: Amide, Asparagine, Biological membrane, Congenital disorder of glycosylation, Dolichol, Endoplasmic reticulum, Enzyme, Gene, Genetic disorder, Glucose, Glycosyltransferase, Mannose, Membrane protein, Metabolic pathway, N-Acetylglucosamine, Nitrogen, Oligomer, Oligosaccharide, OST4, Peptide, Post-translational modification, Proline, Protein, Protein complex, Protein folding, Sequon, Serine, Sugar, Threonine, Translation (biology), Translocon, Undecaprenyl-diphosphooligosaccharide-protein glycotransferase.

Amide

An amide (or or), also known as an acid amide, is a compound with the functional group RnE(O)xNR′2 (R and R′ refer to H or organic groups).

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Asparagine

Asparagine (symbol Asn or N), is an α-amino acid that is used in the biosynthesis of proteins.

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Biological membrane

A biological membrane or biomembrane is an enclosing or separating membrane that acts as a selectively permeable barrier within living things.

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Congenital disorder of glycosylation

A congenital disorder of glycosylation (previously called carbohydrate-deficient glycoprotein syndrome) is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and/or lipids is deficient or defective.

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Dolichol

Dolichol refers to any of a group of long-chain mostly unsaturated organic compounds that are made up of varying numbers of isoprene units terminating in an α-saturated isoprenoid group, containing an alcohol functional group.

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Endoplasmic reticulum

The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Genetic disorder

A genetic disorder is a genetic problem caused by one or more abnormalities in the genome.

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Glucose

Glucose is a simple sugar with the molecular formula C6H12O6.

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Glycosyltransferase

Glycosyltransferases (GTFs, Gtfs) are enzymes (EC 2.4) that establish natural glycosidic linkages.

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Mannose

Mannose, packaged as the nutritional supplement "d-mannose", is a sugar monomer of the aldohexose series of carbohydrates.

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Membrane protein

Membrane proteins are proteins that interact with, or are part of, biological membranes.

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Metabolic pathway

In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.

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N-Acetylglucosamine

N-Acetylglucosamine (N-acetyl-D-glucosamine, or GlcNAc, or NAG) is a monosaccharide and a derivative of glucose.

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Nitrogen

Nitrogen is a chemical element with symbol N and atomic number 7.

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Oligomer

An oligomer (oligo-, "a few" + -mer, "parts") is a molecular complex of chemicals that consists of a few monomer units, in contrast to a polymer, where the number of monomers is, in principle, infinite.

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Oligosaccharide

An oligosaccharide (from the Greek ὀλίγος olígos, "a few", and σάκχαρ sácchar, "sugar") is a saccharide polymer containing a small number (typically three to ten) of monosaccharides (simple sugars).

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OST4

In molecular biology, OST4 (Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 4) is a subunit of the oligosaccharyltransferase complex.

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Peptide

Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

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Post-translational modification

Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.

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Proline

Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein complex

A protein complex or multiprotein complex is a group of two or more associated polypeptide chains.

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Protein folding

Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.

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Sequon

A sequon is a sequence of consecutive amino acids in a protein that can serve as the attachment site to a polysaccharide, frequently an N-linked-Glycan.

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Serine

Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.

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Sugar

Sugar is the generic name for sweet-tasting, soluble carbohydrates, many of which are used in food.

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Threonine

Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins.

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Translation (biology)

In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.

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Translocon

The translocon (commonly known as a translocator or translocation channel) is a complex of proteins associated with the translocation of polypeptides across membranes.

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Undecaprenyl-diphosphooligosaccharide-protein glycotransferase

Undecaprenyl-diphosphooligosaccharide-protein glycotransferase (PglB) is an enzyme with systematic name tritrans,heptacis-undecaprenyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligosaccharidotransferase.

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Redirects here:

Oligosaccharyl transferase.

References

[1] https://en.wikipedia.org/wiki/Oligosaccharyltransferase

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