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Onapristone

Index Onapristone

Onapristone (INN) (developmental code names ZK-89299, ZK-299) is a synthetic, steroidal antiprogestogen with additional antiglucocorticoid activity which was developed by Schering and described in 1984 but was never marketed. [1]

26 relations: Aglepristone, Antiandrogen, Antiglucocorticoid, Antiprogestogen, Breast cancer, Clinical trial, Endometrial cancer, Endometrium, Hormonal contraception, International nonproprietary name, Lilopristone, Liver, Mifepristone, Organic compound, Ovarian cancer, Partial agonist, Potency (pharmacology), Progesterone receptor, Prostate cancer, Receptor (biochemistry), Receptor antagonist, Schering AG, Steroid, Telapristone, Toripristone, Uterine cancer.

Aglepristone

Aglepristone (brand name Alizine; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in veterinary medicine.

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Antiandrogen

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.

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Antiglucocorticoid

An antiglucocorticoid is a drug which reduces glucocorticoid activity in the body.

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Antiprogestogen

Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs which prevent progestogens like progesterone from mediating their biological effects in the body.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Endometrial cancer

Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).

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Endometrium

The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus.

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Hormonal contraception

Hormonal contraception refers to birth control methods that act on the endocrine system.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Lilopristone

Lilopristone (INN) (developmental code names ZK-98734, ZK-734) is a synthetic, steroidal antiprogestogen with additional antiglucocorticoid activity which was developed by Schering and was patented in 1985.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Mifepristone

Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol, to bring about an abortion.

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Organic compound

In chemistry, an organic compound is generally any chemical compound that contains carbon.

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Ovarian cancer

Ovarian cancer is a cancer that forms in or on an ovary.

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Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

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Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

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Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

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Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Schering AG

Schering AG was a research-centered German multinational pharmaceutical company headquartered in Wedding, Berlin, which operated as an independent company from 1851 to 2006.

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Steroid

A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

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Telapristone

Telapristone, as telapristone acetate (proposed brand names Proellex, Progenta; former code name CDB-4124), is a synthetic, steroidal selective progesterone receptor modulator (SPRM) related to mifepristone which is under development by Repros Therapeutics for the treatment of breast cancer, endometriosis, and uterine fibroids.

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Toripristone

Toripristone (INN) (developmental code name RU-40555) is a synthetic, steroidal antiglucocorticoid as well as antiprogestogen which was never marketed.

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Uterine cancer

Uterine cancer, also known as womb cancer, is any type of cancer that emerges from the tissue of the uterus.

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Redirects here:

ZK 299, ZK 89,299, ZK 89299, ZK-299, ZK-89,299, ZK-89299, ZK299, ZK89299.

References

[1] https://en.wikipedia.org/wiki/Onapristone

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