61 relations: Advanced glycation end-product, Alcor Life Extension Foundation, Alliance for Aging Research, American Academy of Anti-Aging Medicine, American Aging Association, Antagonistic pleiotropy hypothesis, Antioxidant, Aubrey de Grey, Biological immortality, Calico (company), Calorie restriction, Cellular senescence, Centenarian, Cross-link, Crosslinking of DNA, Cryonics, Degeneration (medical), Degenerative disease, DNA damage theory of aging, Durk Pearson, Ending Aging, Evolution of ageing, Exercise, Free-radical theory of aging, Genome instability, Gerontology, Geroprotector, Glycation, Immunization, Indefinite lifespan, Intermittent fasting, Leonard Hayflick, Life expectancy, Life extension, Life Extension Foundation, Lipofuscin, Longevity, Longevity escape velocity, Maximum life span, Methuselah Foundation, Michael D. West, Mind uploading, Neurodegeneration, Outline (list), Outline of transhumanism, Radical (chemistry), Rate-of-living theory, Rejuvenation (aging), Reliability theory of aging and longevity, Reproductive-cell cycle theory, ..., Roy Walford, Sandy Shaw, Saul Kent, Senescence, Senolytic, SENS Research Foundation, Stem-cell therapy, Strategies for Engineered Negligible Senescence, Supercentenarian, Suspended animation, Viral disease. Expand index (11 more) » « Shrink index
Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars.
The Alcor Life Extension Foundation, most often referred to as Alcor, is a nonprofit organization based in Scottsdale, Arizona, USA.
The Alliance for Aging Research is a non-profit organization based in Washington, D.C. that was founded to promote medical research to improve the human experience of aging.
The American Academy of Anti-Aging Medicine (A4M) is a United States registered 501(c)(3) nonprofit organization that promotes the questionable field of anti-aging medicine and trains and certifies physicians in this specialty.
The American Aging Association is a non-profit, tax-exempt biogerontology organization of scientists and laypeople dedicated to biomedical aging studies and geroscience, with the goal of slowing the aging process to extend the healthy human lifespan while preserving and restoring functions typically lost to age-related degeneration.
The antagonistic pleiotropy hypothesis was first proposed by George C. Williams in 1957 as an evolutionary explanation for senescence.
Antioxidants are molecules that inhibit the oxidation of other molecules.
Aubrey David Nicholas Jasper de Grey (born 20 April 1963) is an English author and biomedical gerontologist and mathematician who has made a significant contribution to the Hadwiger–Nelson problem.
Biological immortality (sometimes referred to bio-indefinite mortality) is a state in which the rate of mortality from senescence is stable or decreasing, thus decoupling it from chronological age.
Calico is a research and development biotech company founded on September 18, 2013 by Bill Maris and backed by Google with the goal of combating aging and associated diseases.
Calorie restriction, or caloric restriction, or energy restriction, is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients.
Cellular senescence is one phenomenon by which normal cells cease to divide.
A centenarian is a person who lives to or beyond the age of 100 years.
A cross-link is a bond that links one polymer chain to another.
In genetics, crosslinking of DNA occurs when various exogenous or endogenous agents react with two nucleotides of DNA, forming a covalent linkage between them.
Cryonics (from Greek κρύος kryos meaning 'cold') is the low-temperature preservation (usually at −196°C) of human cadavers, with the hope that resuscitation and restoration to life and full health may be possible in the far future.
Degeneration is deterioration in the medical sense.
Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time, whether due to normal bodily wear or lifestyle choices such as exercise or eating habits.
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damages.
Durk Pearson (born 1943 in Illinois) is a research scientist best known for coauthoring a series of books on longevity, beginning with Life Extension: A Practical Scientific Approach.
Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime is a 2007 book written by Aubrey de Grey, a biomedical gerontologist, with his research assistant Michael Rae.
Enquiry into the evolution of ageing aims to explain why survival, reproductive success, and functioning of almost all living organisms decline at old age.
Exercise is any bodily activity that enhances or maintains physical fitness and overall health and wellness.
The free radical theory of aging (FRTA) states that organisms age because cells accumulate free radical damage over time.
Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.
Gerontology is the study of the social, cultural, psychological, cognitive, and biological aspects of ageing.
A geroprotector is a senotherapeutic that aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.
Glycation (sometimes called non-enzymatic glycosylation) is the result of the covalent bonding of a sugar molecule, such as glucose or fructose, to a protein or lipid molecule, without the controlling action of an enzyme.
Immunization, or immunisation, is the process by which an individual's immune system becomes fortified against an agent (known as the immunogen).
Indefinite lifespan (also known as indefinite life extension or bio-indefinite) is a term used in the life extension movement and transhumanism to refer to the hypothetical longevity of humans (and other life-forms) under conditions in which ageing is effectively and completely prevented and treated.
Intermittent fasting (IF) is an umbrella term for various diets that cycle between a period of fasting and non-fasting during a defined period.
Leonard Hayflick (born 20 May 1928) is a Professor of Anatomy at the UCSF School of Medicine, and was Professor of Medical Microbiology at Stanford University School of Medicine.
Life expectancy is a statistical measure of the average time an organism is expected to live, based on the year of its birth, its current age and other demographic factors including gender.
Life extension science, also known as anti-aging medicine, indefinite life extension, experimental gerontology, and biomedical gerontology, is the study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan.
The Life Extension Foundation (LEF) is a nonprofit organization, whose aim is to extend the healthy human lifespan by discovering scientific methods to control aging and eradicate disease.
Lipofuscin is the name given to fine yellow-brown pigment granules composed of lipid-containing residues of lysosomal digestion.
The word "longevity" is sometimes used as a synonym for "life expectancy" in demography.
Longevity escape velocity (sometimes referred to as Actuarial escape velocity) is a term used in the life extension movement.
Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death.
The Methuselah Foundation is a non-profit organization co-founded in 2003 by David Gobel and Aubrey de Grey.
Michael D. West is a gerontologist, and a pioneer in stem cells, cellular aging and telomerase.
Whole brain emulation (WBE), mind upload or brain upload (sometimes called "mind copying" or "mind transfer") is the hypothetical futuristic process of scanning the mental state (including long-term memory and "self") of a particular brain substrate and copying it to a computer.
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
An outline, also called a hierarchical outline, is a list arranged to show hierarchical relationships and is a type of tree structure.
The following outline provides an overview of and a topical guide to transhumanism: Transhumanism – international intellectual and cultural movement that affirms the possibility and desirability of fundamentally transforming the human condition by developing and making widely available technologies to eliminate aging and to greatly enhance human intellectual, physical, and psychological capacities.
In chemistry, a radical (more precisely, a free radical) is an atom, molecule, or ion that has an unpaired valence electron.
The rate of living theory postulates that the faster an organism’s metabolism, the shorter its lifespan.
Rejuvenation is a medical discipline focused on the practical reversal of the aging process.
The reliability theory of aging is an attempt to apply the principles of reliability theory to create a mathematical model of senescence.
Rather than seeing aging as a loss of functionality as we get older, this theory defines aging as any change in an organism over time, as evidenced by the fact that if all chemical reactions in the body were stopped, no change, and thus no aging, would occur.
Roy Lee Walford, M. D. (June 29, 1924 - April 27, 2004) was a pioneer in the field of caloric restriction.
Sandy Shaw (formerly Sandy Shakocius) (born 1943) is an American writer on health.
Saul Kent is a life extension activist, and co-founder of the Life Extension Foundation, a dietary supplement vendor and promoter of anti-aging research.
Senescence or biological ageing is the gradual deterioration of function characteristic of most complex lifeforms, arguably found in all biological kingdoms, that on the level of the organism increases mortality after maturation.
A senolytic (from the words “senescence” and “lytic” – destroying) is among the class of small molecules under basic research to determine if they can selectively induce death of senescent cells.
The SENS Research Foundation (Strategies for Engineered Negligible Senescence Research Foundation) is a 501(c)(3) non-profit organization and regenerative medical research foundation co-founded by Michael Kope, Aubrey de Grey, Jeff Hall, Sarah Marr and Kevin Perrott, which is based in Mountain View, California, United States.
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.
Strategies for Engineered Negligible Senescence (SENS) is the term coined by British biogerontologist Aubrey de Grey for the diverse range of regenerative medical therapies, either planned or currently in development, for the periodical repair of all age-related damage to human tissue with the ultimate purpose of maintaining a state of negligible senescence in the patient, thereby postponing age-associated disease for as long as the therapies are reapplied.
A supercentenarian (sometimes hyphenated as super-centenarian) is someone who has lived to or passed their 110th birthday.
Suspended animation is the inducement of a temporary cessation or decay of main body functions, including the brain, to a hypometabolic state in order to try to preserve its mental and physiological capabilities.
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells.