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Oxidopamine

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Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. [1]

18 relations: Desipramine, Dopamine, Dopaminergic, DSP-4, FAUC50, Lesch–Nyhan syndrome, Monoamine transporter, MPTP, Neurotoxin, Norepinephrine, Norsalsolinol, Organic compound, Parkinson's disease, Parkinsonism, Rotenone, Substantia nigra, Superoxide, 5,7-Dihydroxytryptamine.

Desipramine

Desipramine, sold under the brand name Norpramin and Pertofrane among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Dopaminergic

Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.

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DSP-4

For the Super NES enhancement chip see List of Super NES enhancement chips DSP-4, or N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, is a neurotoxin selective for noradrenergic neurons, capable of crossing the blood–brain barrier.

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FAUC50

FAUC50 is a template molecular skeletal super-structure that can have different joined native-head groups added to its chemical composition to make various biogenic amines, catecholamines and neurotransmitters of those aforementioned categories into covalent binding ligands.

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Lesch–Nyhan syndrome

Lesch–Nyhan syndrome (LNS), also known as juvenile gout, is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT), produced by mutations in the HPRT gene located on the X chromosome.

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Monoamine transporter

Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters.

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MPTP

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain.

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Neurotoxin

Neurotoxins are toxins that are poisonous or destructive to nerve tissue (causing neurotoxicity).

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Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

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Norsalsolinol

Norsalsolinol is a chemical compound that is produced naturally in the body through metabolism of dopamine.

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Organic compound

In chemistry, an organic compound is generally any chemical compound that contains carbon.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Parkinsonism

Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia, rigidity, and postural instability.

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Rotenone

Rotenone is an odorless, colorless, crystalline isoflavone used as a broad-spectrum insecticide, piscicide, and pesticide.

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Substantia nigra

The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.

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Superoxide

A superoxide is a compound that contains the superoxide anion, which has the chemical formula.

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5,7-Dihydroxytryptamine

5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin in the brain.

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Redirects here:

6 OHDA, 6-HD, 6-Hydroxydopamine, 6-OHDA, 6-hydroxydopamine, 6-ohda, C8H11N1O3, Ohda, Oxadopamine.

References

[1] https://en.wikipedia.org/wiki/Oxidopamine

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