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49 relations: Actin, C-type lectin, Calcium in biology, CD15, Cell adhesion molecule, Cell culture, Cell membrane, Chondroitin sulfate, Crizanlizumab, CUB domain, Cytokine, Cytoplasm, E-selectin, EGF-like domain, Endothelial activation, Endothelium, Eosinophil, Exon, Extracellular, Fucoidan, Gene, Glycosaminoglycan, Granule (cell biology), Hematopoietic stem cell, Heparan sulfate, Heparin, Inflammation, Interleukin 13, Interleukin 4, L-selectin, Lymphocyte, Megakaryocyte, Monocyte, Mucin, N-terminus, Neutrophil, Oligosaccharide, P-selectin glycoprotein ligand-1, Platelet, Platelet alpha-granule, Protease, Protein, Selectin, Sialic acid, Sulfation, Thrombin, Weibel–Palade body, White blood cell, 4T1.
Actin
Actin is a family of globular multi-functional proteins that form microfilaments.
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C-type lectin
A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin.
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Calcium in biology
Calcium ions (Ca2+) play a vital role in the physiology and biochemistry of organisms and the cell.
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CD15
CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule.
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Cell adhesion molecule
Cell adhesion molecules (CAMs) are proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion.
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Cell culture
Cell culture is the process by which cells are grown under controlled conditions, generally outside their natural environment.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Chondroitin sulfate
Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).
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Crizanlizumab
Crizanlizumab is a monoclonal antibody developed by Novartis targeted towards P-selectin.
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CUB domain
CUB domain is an evolutionarily conserved protein domain.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Cytoplasm
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
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E-selectin
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines.
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EGF-like domain
The EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described.
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Endothelial activation
Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Eosinophil
Eosinophils sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply. These cells are eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes: Normally transparent, it is this affinity that causes them to appear brick-red after staining with eosin, a red dye, using the Romanowsky method. The staining is concentrated in small granules within the cellular cytoplasm, which contain many chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite and host tissues. In normal individuals, eosinophils make up about 1–3% of white blood cells, and are about 12–17 micrometres in size with bilobed nuclei. While they are released into the bloodstream as neutrophils are, eosinophils reside in tissue They are found in the medulla and the junction between the cortex and medulla of the thymus, and, in the lower gastrointestinal tract, ovary, uterus, spleen, and lymph nodes, but not in the lung, skin, esophagus, or some other internal organs under normal conditions. The presence of eosinophils in these latter organs is associated with disease. For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments.
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Extracellular
In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".
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Fucoidan
Fucoidan is a sulfated polysaccharide (MW: average 20,000) found mainly in various species of brown algae and brown seaweed such as mozuku, kombu, bladderwrack, wakame, and hijiki (variant forms of fucoidan have also been found in animal species, including the sea cucumber).
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glycosaminoglycan
Glycosaminoglycans (GAGs) or mucopolysaccharides are long unbranched polysaccharides consisting of a repeating disaccharide unit.
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Granule (cell biology)
In cell biology, a granule is a small particle.
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Hematopoietic stem cell
Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.
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Heparan sulfate
Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues.
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Heparin
Heparin, also known as unfractionated heparin (UFH), is medication which is used as an anticoagulant (blood thinner).
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Interleukin 13
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene.
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Interleukin 4
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells.
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L-selectin
L-selectin, also known as CD62L, is a cell adhesion molecule found on lymphocytes and the preimplantation embryo.
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Lymphocyte
A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.
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Megakaryocyte
A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting.
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Monocyte
Monocytes are a type of leukocyte, or white blood cell.
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Mucin
Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Neutrophil
Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.
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Oligosaccharide
An oligosaccharide (from the Greek ὀλίγος olígos, "a few", and σάκχαρ sácchar, "sugar") is a saccharide polymer containing a small number (typically three to ten) of monosaccharides (simple sugars).
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P-selectin glycoprotein ligand-1
Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene.
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Platelet
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.
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Platelet alpha-granule
In platelets, the term "alpha granules" is used to describe granules containing several growth factors.
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Protease
A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Selectin
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs).
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Sialic acid
Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone.
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Sulfation
Sulfation or sulfurylation (not to be confused with sulfonation) in biochemistry is the enzyme-catalyzed conjugation of a sulfo group (not a sulfate or sulfuryl group) to another molecule.
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Thrombin
Thrombin (fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
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Weibel–Palade body
Weibel–Palade bodies are the storage granules of endothelial cells, the cells that form the inner lining of the blood vessels and heart.
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White blood cell
White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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4T1
4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse.
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Redirects here:
CD62P, Cd62p, GMP-140, GMP140, Gmp140, Granule Membrane Protein 140, PADGEM, Padgem, Platelet Activation-Dependent Granule to External Membrane Protein, SELP, SELP (gene), Selectin P.
References
[1] https://en.wikipedia.org/wiki/P-selectin
