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Index P16

p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene. [1]

57 relations: Aging (journal), Ankyrin repeat, Base pair, Biomarker, Biomarkers in Medicine, Cancer, CCNG1, CDKN2A, Cell cycle, Cervical cancer, Cervical intraepithelial neoplasia, Chromosome 9, Cyclin D, Cyclin-dependent kinase, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Death-associated protein 6, Deletion (genetics), E2F1, E4F1, Enzyme inhibitor, Epigenetics, Esophageal cancer, Exon, Fluorescence in situ hybridization, G1 phase, Gene, Human papillomavirus infection, Immortalised cell line, Mdm2, Melanoma, Mesothelioma, Molecular mass, Oropharyngeal cancer, P14arf, P21, P53, Pancreatic cancer, PPP1R9B, Protein, Protein isoform, Protein–protein interaction, Reactive oxygen species, Retinoblastoma protein, RNA splicing, S phase, Senescence, Senescence-associated beta-galactosidase, SERTAD1, Skin cancer, ..., Squamous cell carcinoma, Stem cell, Stomach cancer, Transcription (biology), Tumor suppressor, Unified atomic mass unit, 60S ribosomal protein L11. Expand index (7 more) »

Aging (journal)

Aging is a peer-reviewed open access scientific journal.

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Ankyrin repeat

The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch.

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Base pair

A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.

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A biomarker, or biological marker, generally refers to a measurable indicator of some biological state or condition.

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Biomarkers in Medicine

Biomarkers in Medicine is a monthly peer-reviewed medical journal established in 2007 and published by Future Medicine.

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Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.

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CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

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Cervical cancer

Cervical cancer is a cancer arising from the cervix.

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Cervical intraepithelial neoplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer.

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Chromosome 9

Chromosome 9 is one of the 23 pairs of chromosomes in humans.

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Cyclin D

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression.

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Cyclin-dependent kinase

Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin-dependent kinases (CDKs) are a family of sugar kinases first discovered for their role in regulating the cell cycle.

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Cyclin-dependent kinase 4

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene.

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Cyclin-dependent kinase 6

Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.

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Death-associated protein 6

Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene.

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Deletion (genetics)

In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is lost during DNA replication.

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Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

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Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.

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Enzyme inhibitor

4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.

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Esophageal cancer

Esophageal cancer is cancer arising from the esophagus—the food pipe that runs between the throat and the stomach.

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An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

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Fluorescence in situ hybridization

Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity.

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G1 phase

The g1 phase, or Gap 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division.

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Human papillomavirus infection

Human papillomavirus infection is an infection by human papillomavirus (HPV).

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Immortalised cell line

An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.

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Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene.

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Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium).

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Molecular mass

Relative Molecular mass or molecular weight is the mass of a molecule.

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Oropharyngeal cancer

Oropharyngeal cancer is a disease in which cancer form in the tissues of the throat (oropharynx).

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p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus).

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p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2.

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Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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Pancreatic cancer

Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.

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Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein isoform

A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.

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RNA splicing

In molecular biology, splicing is the editing of the nascent precursor messenger RNA (pre-mRNA) transcript into a mature messenger RNA (mRNA).

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S phase

S phase (synthesis phase) is the part of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.

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Senescence or biological ageing is the gradual deterioration of function characteristic of most complex lifeforms, arguably found in all biological kingdoms, that on the level of the organism increases mortality after maturation.

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Senescence-associated beta-galactosidase

Senescence-associated beta-galactosidase (SA-β-gal or SABG) is a hypothetical hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides only in senescent cells.

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SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.

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Skin cancer

Skin cancers are cancers that arise from the skin.

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Squamous cell carcinoma

Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from squamous cells.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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Stomach cancer

Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

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Unified atomic mass unit

The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).

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60S ribosomal protein L11

60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.

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CDNK2A, Genes, p16, INK4a, P 16, P-16, P.16, P16 (gene), P16-ink4a, P16INK4a, Protein P16.


[1] https://en.wikipedia.org/wiki/P16

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