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p16 (also known as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene. [1]

51 relations: Ankyrin repeat, Base pair, Cancer, Carlos Cordon-Cardo, CCNG1, CDK, Cell culture, Cell cycle, Cervical cancer, Chromosome 9 (human), Cyclin D, Cyclin-dependent kinase, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Death-associated protein 6, Deletion (genetics), E2F1, E4F1, Enzyme inhibitor, Epigenetics, Esophageal cancer, Exon, Fluorescence in situ hybridization, G1 phase, Gene, Human papillomavirus, Mdm2, Melanoma, Mesothelioma, Oropharyngeal cancer, P14arf, P21, P53, Pancreatic cancer, Phosphorylation, PPP1R9B, Protein, Protein isoform, Protein–protein interaction, Retinoblastoma protein, RNA splicing, RPL11, S phase, Senescence, SERTAD1, Skin cancer, Squamous-cell carcinoma, Stem cell, Stomach cancer, Transcription (genetics), ..., Tumor suppressor gene. Expand index (1 more) »

Ankyrin repeat

The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch.

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Base pair

Base pairs (unit: bp), which form between specific nucleobases (also termed nitrogenous bases), are the building blocks of the DNA double helix and contribute to the folded structure of both DNA and RNA.

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Cancer, also known as a malignant tumor or malignant neoplasm, is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Carlos Cordon-Cardo

Carlos Cordon-Cardo (born 1957) is a Spanish-born American physician and scientist known for his research in experimental pathology and molecular oncology.

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Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.

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CDK may refer to.

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Cell culture

Cell culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication (replication) that produces two daughter cells.

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Cervical cancer

Cervical cancer is a cancer arising from the cervix.

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Chromosome 9 (human)

Chromosome 9 is one of the 23 pairs of chromosomes in humans.

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Cyclin D

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression.

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Cyclin-dependent kinase

Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin-dependent kinases (CDKs) are a family of protein kinases first discovered for their role in regulating the cell cycle.

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Cyclin-dependent kinase 4

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene.

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Cyclin-dependent kinase 6

Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.

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Death-associated protein 6

Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene.

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Deletion (genetics)

In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is lost during DNA replication.

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Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

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Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.

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Enzyme inhibitor

An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Epigenetics is the study, in the field of genetics, of cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence.

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Esophageal cancer

Esophageal cancer (or oesophageal cancer) is cancer arising from the esophagus—the food pipe that runs between the throat and the stomach.

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An exon is any part of a gene that codes for a part of the final mature RNA product of that gene after introns have been removed by RNA splicing.

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Fluorescence in situ hybridization

Fluorescence in situ hybridization (FISH) is a cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity.

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G1 phase

The G1 phase, or Growth 1/Gap 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division.

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A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity.

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Human papillomavirus

Human papillomavirus (HPV) is a DNA virus from the papillomavirus family that is capable of infecting humans.

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Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene.

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Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Mesothelioma (or, more precisely, malignant mesothelioma) is a rare form of cancer that develops from cells of the mesothelium, the protective lining that covers many of the internal organs of the body.

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Oropharyngeal cancer

Oropharyngeal cancer is a disease in which malignant cells form in the tissue of oropharynx.

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p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus).

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p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor that inhibits the complexes of CDK2 and CDK1.

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Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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Pancreatic cancer

Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.

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Phosphorylation is the addition of a phosphate (PO43−) group to a protein or other organic molecule.

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Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein isoform

A protein isoform is any of several different forms of the same protein.

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Protein–protein interaction

Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.

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Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.

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RNA splicing

In molecular biology and genetics, splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined.

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60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.

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S phase

S-phase (synthesis phase) is the part of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.

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Senescence (from senescere, meaning "to grow old", from senex) or biological aging (also spelled biological ageing) is the gradual deterioration of function characteristic of most complex lifeforms, arguably found in all biological kingdoms, that on the level of the organism increases mortality after maturation.

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SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.

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Skin cancer

Skin cancers are cancers that arise from the skin.

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Squamous-cell carcinoma

Squamous-cell carcinoma or squamous-cell cancer (SCC or SqCC) is a cancer of a kind of epithelial cell, the squamous cell.

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Stem cell

Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells.

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Stomach cancer

Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach.

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Transcription (genetics)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerase.

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Tumor suppressor gene

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

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Redirects here:

CDNK2A, Genes, p16, P 16, P-16, P.16, P16 (gene), P16-ink4a, P16INK4a, Protein P16.


[1] https://en.wikipedia.org/wiki/P16

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