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14 relations: Agonist, AZD-5423, Clinical trial, Ester, Fosdagrocorat, Glucocorticoid receptor, Hydrogen, Mapracorat, Nonsteroidal, Partial agonist, Phosphate, Rheumatoid arthritis, Selective glucocorticoid receptor modulator, Steroid.
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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AZD-5423
AZD-5423 is a nonsteroidal glucocorticoid and phase II experimental drug being developed by AstraZeneca and disclosed at the spring 2013 American Chemical Society meeting in New Orleans to treat respiratory diseases and in particular chronic obstructive pulmonary disease.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Ester
In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.
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Fosdagrocorat
Fosdagrocorat (developmental code names PF-04171327, PF-4171327), also known as dagrocorat 2-(dihydrogen phosphate), is a nonsteroidal but steroid-like selective glucocorticoid receptor modulator (SGRM) which was under development for the treatment of rheumatoid arthritis but was never marketed.
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Glucocorticoid receptor
The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.
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Hydrogen
Hydrogen is a chemical element with symbol H and atomic number 1.
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Mapracorat
Mapracorat (INN, code names BOL-303242-X, ZK-245186) is an anti-inflammatory drug belonging to the experimental class of selective glucocorticoid receptor agonists (SEGRAs).
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Nonsteroidal
Nonsteroidal is a term which is used to describe a compound that is not a steroid.
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Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
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Phosphate
A phosphate is chemical derivative of phosphoric acid.
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Rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints.
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Selective glucocorticoid receptor modulator
Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as dissociated glucocorticoid receptor agonists (DIGRAs) are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer properties of classical glucocorticoid drugs but with fewer side effects such as skin atrophy.
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Steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
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