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47 relations: Agonist, Anabolism, Androgen receptor, Aromatase, Azasteroid, Binding selectivity, Cholesterol, Dihydrotestosterone, Elevated transaminases, Endometrium, Enzyme inhibitor, Estrogen, Gene, Gene expression, Glucocorticoid receptor, GTx Incorporated, Gynecomastia, High-density lipoprotein, IC50, In vivo, Lean body mass, Lipid, Merck & Co., Metabolism, Muscle, Nuclear receptor coactivator 2, Oral administration, Partial agonist, Placebo, Potency (pharmacology), Progesterone receptor, Prostate, Reproductive system, Sarcopenia, Sebaceous gland, Selective androgen receptor modulator, Seminal vesicle, Side effect, Statistical significance, Steroid, Steroid hormone receptor, Testosterone (medication), TFM-4AS-1, Uterus, Virilization, YK-11, 5α-Reductase.
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Anabolism
Anabolism (from ἁνά, "upward" and βάλλειν, "to throw") is the set of metabolic pathways that construct molecules from smaller units.
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Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
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Aromatase
Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens.
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Azasteroid
An azasteroid is a type of steroid derivative which has one of the carbon atoms in the steroid ring system replaced by a nitrogen atom.
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Binding selectivity
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
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Cholesterol
Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.
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Dihydrotestosterone
Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.
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Elevated transaminases
In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver damage.
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Endometrium
The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus.
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Enzyme inhibitor
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
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Estrogen
Estrogen, or oestrogen, is the primary female sex hormone.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
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Glucocorticoid receptor
The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.
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GTx Incorporated
GTx, Inc is a pharmaceutical company that is working on drugs in the selective estrogen receptor modulator (SERM) and selective androgen receptor modulator (SARM) classes.
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Gynecomastia
Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.
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High-density lipoprotein
High-density lipoproteins (HDL) are one of the five major groups of lipoproteins.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Lean body mass
Lean body mass is a component of body composition, calculated by subtracting body fat weight from total body weight: total body weight is lean plus fat.
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Lipid
In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.
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Merck & Co.
Merck & Company, Inc., d.b.a. Merck Sharp & Dohme (MSD) outside the United States and Canada, is an American pharmaceutical company and one of the largest pharmaceutical companies in the world.
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Muscle
Muscle is a soft tissue found in most animals.
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Nuclear receptor coactivator 2
The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene.
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Oral administration
| name.
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Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
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Placebo
A placebo is a substance or treatment of no intended therapeutic value.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Progesterone receptor
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.
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Prostate
The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.
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Reproductive system
The reproductive system or genital system is a system of sex organs within an organism which work together for the purpose of sexual reproduction.
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Sarcopenia
Sarcopenia is the degenerative loss of skeletal muscle mass (0.5–1% loss per year after the age of 50), quality, and strength associated with aging.
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Sebaceous gland
Sebaceous glands are microscopic exocrine glands in the skin that secrete an oily or waxy matter, called sebum, to lubricate and waterproof the skin and hair of mammals.
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Selective androgen receptor modulator
Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands.
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Seminal vesicle
The seminal vesicles (glandulae vesiculosae), vesicular glands, or seminal glands, are a pair of simple tubular glands posteroinferior to the urinary bladder of some male mammals.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Statistical significance
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis.
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Steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
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Steroid hormone receptor
Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells.
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Testosterone (medication)
Testosterone is a medication and naturally occurring steroid hormone.
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TFM-4AS-1
TFM-4AS-1 is a dual selective androgen receptor modulator (SARM) and 5α-reductase inhibitor.
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Uterus
The uterus (from Latin "uterus", plural uteri) or womb is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.
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Virilization
Virilization or masculinization is the biological development of sex differences, changes that make a male body different from a female body.
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YK-11
YK-11 is a synthetic, steroidal selective androgen receptor modulator (SARM).
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5α-Reductase
5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.
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Redirects here:
MK 0773, MK0773, PF 05314882, PF-05314882, PF05314882.
References
[1] https://en.wikipedia.org/wiki/MK-0773
