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Midostaurin

Index Midostaurin

Midostaurin (sold under the name Rydapt) is a multi-targeted protein kinase inhibitor that has been investigated for the treatment of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and advanced systemic mastocytosis. [1]

20 relations: Acute myeloid leukemia, Alkaloid, CD117, CD135, Clinical trial, Coagulation, Disease, Drugs.com, Febrile neutropenia, Mast cell leukemia, Mastocytosis, Myelodysplastic syndrome, Nausea, Open-label trial, Protein kinase inhibitor, Skin, Staurosporine, Streptomyces, Therapy, Upper respiratory tract infection.

Acute myeloid leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.

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Alkaloid

Alkaloids are a class of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.

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CD117

Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene.

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CD135

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Coagulation

Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.

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Disease

A disease is any condition which results in the disorder of a structure or function in an organism that is not due to any external injury.

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Drugs.com

Drugs.com is an online pharmaceutical encyclopedia which provides drug information for consumers and healthcare professionals, primarily in the USA.

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Febrile neutropenia

Febrile neutropenia is the development of fever, often with other signs of infection, in a patient with neutropenia, an abnormally low number of neutrophil granulocytes (a type of white blood cell) in the blood.

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Mast cell leukemia

Mast cell leukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de novo but can, rarely, evolve from transformation of chronic myeloid leukemia into the more aggressive acute myeloid leukemia.

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Mastocytosis

Mastocytosis, a type of mast cell disease, is a rare disorder affecting both children and adults caused by the accumulation of functionally defective mast cells (also called mastocytes) and CD34+ mast cell precursors.

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Myelodysplastic syndrome

Myelodysplastic syndromes (MDS) are a group of cancers in which immature blood cells in the bone marrow do not mature and therefore do not become healthy blood cells.

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Nausea

Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.

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Open-label trial

An open-label trial, or open trial, is a type of clinical trial in which both the researchers and participants know which treatment is being administered.

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Protein kinase inhibitor

A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.

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Skin

Skin is the soft outer tissue covering vertebrates.

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Staurosporine

Staurosporine (antibiotic AM-2282 or STS) is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus.

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Streptomyces

Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae.

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Therapy

Therapy (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a diagnosis.

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Upper respiratory tract infection

Upper respiratory tract infections (URTI) are illnesses caused by an acute infection which involves the upper respiratory tract including the nose, sinuses, pharynx or larynx.

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Redirects here:

PKC412, Rydapt.

References

[1] https://en.wikipedia.org/wiki/Midostaurin

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