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29 relations: ABCA1, Aleglitazar, Atherosclerosis, Bezafibrate, Blood sugar level, Cholesterol, Ciprofibrate, Clofibrate, Diabetes mellitus, Fenofibrate, Fibrate, Gemfibrozil, GW501516, Ibuprofen, Indole, Insulin resistance, Medication, Metabolic syndrome, Muraglitazar, Nonsteroidal anti-inflammatory drug, Peroxisome proliferator-activated receptor, Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor delta, Peroxisome proliferator-activated receptor gamma, Saroglitazar, Tesaglitazar, Therapy, Thiazolidinedione, Triglyceride.
ABCA1
ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene.
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Aleglitazar
Aleglitazar is a peroxisome proliferator-activated receptor agonist (hence a PPAR modulator) with affinity to PPARα and PPARγ, which was under development by Hoffmann–La Roche for the treatment of type II diabetes.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Bezafibrate
Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used as a lipid-lowering agent to treat hyperlipidaemia.
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Blood sugar level
The blood sugar level, blood sugar concentration, or blood glucose level is the amount of glucose present in the blood of humans and other animals.
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Cholesterol
Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.
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Ciprofibrate
Ciprofibrate is a fibrate that was developed as a lipid-lowering agent.
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Clofibrate
Clofibrate (tradename Atromid-S) is an organic compound.
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Diabetes mellitus
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.
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Fenofibrate
Fenofibrate, marketed as Tricor and under several other brand names, is a drug of the fibrate class.
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Fibrate
In pharmacology, the fibrates are a class of amphipathic carboxylic acids.
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Gemfibrozil
Gemfibrozil is the generic name for an oral drug used to lower lipid levels.
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GW501516
GW501516 (also known as GW-501,516, GW1516, GSK-516 and on the black market as Endurobol) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.
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Ibuprofen
Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation.
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Indole
Indole is an aromatic heterocyclic organic compound with formula C8H7N.
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Insulin resistance
Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin.
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Medication
A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
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Metabolic syndrome
Metabolic syndrome, sometimes known by other names, is a clustering of at least three of the five following medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides and low high-density lipoprotein (HDL) levels.
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Muraglitazar
Muraglitazar (proposed tradename Pargluva) is a dual peroxisome proliferator-activated receptor agonist with affinity to PPARα and PPARγ.
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Nonsteroidal anti-inflammatory drug
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation.
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Peroxisome proliferator-activated receptor
In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes.
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Peroxisome proliferator-activated receptor alpha
Peroxisome proliferator-activated receptor alpha (PPAR-alpha), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein that in humans is encoded by the PPARA gene.
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Peroxisome proliferator-activated receptor delta
Peroxisome proliferator-activated receptor beta or delta (PPAR-β or PPAR-δ), also known as NR1C2 (nuclear receptor subfamily 1, group C, member 2) is a nuclear receptor that in humans is encoded by the PPARD gene.
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Peroxisome proliferator-activated receptor gamma
Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor that in humans is encoded by the PPARG gene.
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Saroglitazar
Saroglitazar (INN, trade name Lipaglyn) is a drug for the treatment of type 2 diabetes mellitus and dyslipidemia.
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Tesaglitazar
Tesaglitazar (also known as AZ 242) is a dual peroxisome proliferator-activated receptor agonist with affinity to PPARα and PPARγ, proposed for the management of type 2 diabetes.
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Therapy
Therapy (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a diagnosis.
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Thiazolidinedione
The thiazolidinediones, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, are a class of heterocyclic compounds consisting of a five-membered C3NS ring.
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Triglyceride
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from tri- and glyceride).
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Glitazar, PPAR modulator, PPAR-alpha agonist, PPAR-delta agonist, PPAR-gamma agonist, PPARα agonist, PPARγ agonist, PPARδ agonist, Peroxisome proliferator-activated receptor agonist.
References
[1] https://en.wikipedia.org/wiki/PPAR_agonist
