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PR-104

Index PR-104

PR-104 is a drug from the class of hypoxia-activated prodrugs (HAPs), which is being researched as a potential anti-cancer therapeutic agent. [1]

5 relations: AKR1C3, Cancer, Hypoxia-activated prodrug, Nitrogen mustard, Tumor hypoxia.

AKR1C3

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Hypoxia-activated prodrug

Hypoxia-Activated Prodrugs (HAPs) are prodrugs that target regions of tumor hypoxia within tumor cells.

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Nitrogen mustard

Nitrogen mustards are cytotoxic chemotherapy agents derived from mustard gas.

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Tumor hypoxia

Tumor hypoxia is the situation where tumor cells have been deprived of oxygen.

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References

[1] https://en.wikipedia.org/wiki/PR-104

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