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PDX1

Index PDX1

PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. [1]

40 relations: Anatomical terms of location, Beta cell, Brunner's glands, CDX2, Diabetes mellitus, Doxycycline, Duodenum, Endocrine system, Endoderm, Enterocyte, Epithelium, Exocrine gland, Fat sand rat, FGF10, Foregut, Glucagon, Insulin, Lafarge (company), MAF (gene), MAFA (gene), MAFB (gene), Maturity onset diabetes of the young, MNX1, Neurogenins, NKX6-1, Notch signaling pathway, Pancreas, Pancreatic bud, Pancreatic islets, Pancreatic progenitor cell, ParaHox, Protein, Protein–protein interaction, PTF1A, Pylorus, Somatostatin, SOX2, Stomach cancer, Tetracycline, Transcription factor.

Anatomical terms of location

Standard anatomical terms of location deal unambiguously with the anatomy of animals, including humans.

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Beta cell

Beta cells (β cells) are a type of cell found in the pancreatic islets of the pancreas.

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Brunner's glands

Brunner's glands (or duodenal glands) are compound tubular submucosal glands found in that portion of the duodenum which is above the hepatopancreatic sphincter (a.k.a. sphincter of Oddi).

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CDX2

Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene.

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Diabetes mellitus

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.

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Doxycycline

Doxycycline is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa.

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Duodenum

The duodenum is the first section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds.

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Endocrine system

The endocrine system is a chemical messenger system consisting of hormones, the group of glands of an organism that carry those hormones directly into the circulatory system to be carried towards distant target organs, and the feedback loops of homeostasis that the hormones drive.

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Endoderm

Endoderm is one of the three primary germ layers in the very early embryo.

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Enterocyte

Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells found in the small intestine.

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Epithelium

Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.

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Exocrine gland

Exocrine glands are glands that produce and secrete substances onto an epithelial surface by way of a duct.

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Fat sand rat

The fat sand rat (Psammomys obesus) is a terrestrial mammal from the gerbil subfamily that is mostly found in North Africa and the Middle East, ranging from Mauritania to the Arabian Peninsula.

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FGF10

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.

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Foregut

The foregut is the anterior part of the alimentary canal, from the mouth to the duodenum at the entrance of the bile duct, and is attached to the abdominal walls by mesentery.

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Glucagon

Glucagon is a peptide hormone, produced by alpha cells of the pancreas.

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Insulin

Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.

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Lafarge (company)

Lafarge is a French industrial company specialising in three major products: cement, construction aggregates, and concrete.

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MAF (gene)

Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.

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MAFA (gene)

Transcription factor MafA is a protein that in humans is encoded by the MAFA gene.

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MAFB (gene)

Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in humans is encoded by the MAFB gene.

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Maturity onset diabetes of the young

"Maturity onset diabetes of the young" (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production.

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MNX1

Motor neuron and pancreas homeobox 1 (MNX1), also known as Homeobox HB9 (HLXB9), is a human protein encoded by the MNX1 gene.

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Neurogenins

Neurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation.

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NKX6-1

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.

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Notch signaling pathway

The Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms.

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Pancreas

The pancreas is a glandular organ in the digestive system and endocrine system of vertebrates.

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Pancreatic bud

The ventral and dorsal pancreatic buds (or pancreatic diverticula) are outgrowths of the duodenum during human embryogenesis.

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Pancreatic islets

The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans.

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Pancreatic progenitor cell

Pancreatic progenitor cells are multipotent stem cells originating from the developing fore-gut endoderm which have the ability to differentiate into the lineage specific progenitors responsible for the developing pancreas.

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ParaHox

The ParaHox gene cluster is an array of homeobox genes (involved in morphogenesis, the regulation of patterns of anatomical development) from the Gsx, Xlox (Pdx) and Cdx gene families.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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PTF1A

Pancreas transcription factor 1 subunit alpha is a protein that in humans is encoded by the PTF1A gene.

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Pylorus

The pylorus, or pyloric part, connects the stomach to the duodenum.

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Somatostatin

Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.

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SOX2

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells.

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Stomach cancer

Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach.

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Tetracycline

Tetracycline, sold under the brand name Sumycin among others, is an antibiotic used to treat a number of infections.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Redirects here:

IPF1, Insulin promoter factor 1, Insulin promoter factor-1, Ipf1, PDX1 (gene), Pancreatic and duodenal homeobox protein, Pdx1.

References

[1] https://en.wikipedia.org/wiki/PDX1

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