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Perfosfamide

Index Perfosfamide

Perfosfamide, or 4-hydroperoxycyclophosphamide (trade name Pergamid) was an experimental drug candidate for blood cancers that was rejected by the FDA in 1993 and never reached the market. [1]

13 relations: Acrolein, Acute myeloid leukemia, Cyclophosphamide, Graft-versus-host disease, Hematopoietic stem cell, Hematopoietic stem cell transplantation, Intravenous therapy, Lymphocyte, Mafosfamide, Malignancy, New Drug Application, Randomized controlled trial, 4-Hydroxycyclophosphamide.

Acrolein

Acrolein (systematic name: propenal) is the simplest unsaturated aldehyde.

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Acute myeloid leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.

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Cyclophosphamide

Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system.

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Graft-versus-host disease

Graft-versus-host disease (GvHD) is a medical complication following the receipt of transplanted tissue from a genetically different person.

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Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.

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Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Mafosfamide

No description.

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Malignancy

Malignancy is the tendency of a medical condition to become progressively worse.

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New Drug Application

The Food and Drug Administration's New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.

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Randomized controlled trial

A randomized controlled trial (or randomized control trial; RCT) is a type of scientific (often medical) experiment which aims to reduce bias when testing a new treatment.

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4-Hydroxycyclophosphamide

4-Hydroxycyclophosphamide is in the class of oxazaphosphorine compounds, and is the main, active metabolite of cyclophosphamide and of mafosfamide after they partially metabolized by cytochrome P450.

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Redirects here:

4-HC, 4-HPCY, 4-Hydroperoxycyclophosphamide, 4-OOH-cyclophosphamide, 4-hydroperoxycyclophosphamide, Hydroxycyclophosphamide, Pergamid.

References

[1] https://en.wikipedia.org/wiki/Perfosfamide

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