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Plasmacytoid dendritic cell

Index Plasmacytoid dendritic cell

Plasmacytoid dendritic cells (pDCs) are a rare type of immune cell that are known to secrete large quantities of type 1 interferon (IFNs) in response to a viral infection. [1]

39 relations: Adaptive immune system, Alanine aminopeptidase, Autoantibody, Autoimmune disease, C-C chemokine receptor type 7, CD135, CD14, CD33, CD4, CD80, CD83, CD86, CLEC4C, CpG Oligodeoxynucleotide, Cytokine, Dendritic cell, HIV, HLA-DR, Innate immune system, Integrin alpha M, Integrin alpha X, Interferon gamma, Interferon type I, Interleukin 12, Interleukin 6, Interleukin-3 receptor, LILRA4, MHC class I, MHC class II, Natural killer cell, Neuropilin, Peripheral blood mononuclear cell, Psoriasis, RNA, Systemic lupus erythematosus, Tetherin, TLR7, TLR9, Tumor necrosis factor alpha.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate pathogens or prevent their growth.

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Alanine aminopeptidase

Membrane alanyl aminopeptidase also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N) is an enzyme that in humans is encoded by the ANPEP gene.

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Autoantibody

An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins.

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Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.

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C-C chemokine receptor type 7

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.

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CD135

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene.

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CD14

CD14 (cluster of differentiation 14) is a human gene.

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CD33

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage.

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CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

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CD80

Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival.

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CD83

CD83 (Cluster of Differentiation 83) is a human protein encoded by the gene.

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CD86

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival.

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CLEC4C

CLEC4C is a membrane protein of plasmacytoid dendritic cells used as a marker for this kind of cells and denoted as CD303 in the nomenclature of the Cluster of differentiation.

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CpG Oligodeoxynucleotide

CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G").

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Dendritic cell

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.

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HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

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HLA-DR

HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31.

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Innate immune system

The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.

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Integrin alpha M

Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3).

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Integrin alpha X

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c.

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Interferon gamma

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.

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Interferon type I

Human type I interferons (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system.

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Interleukin 12

Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.

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Interleukin 6

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.

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Interleukin-3 receptor

The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

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LILRA4

Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the LILRA4 gene.

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MHC class I

MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates.

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MHC class II

MHC class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells.

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Natural killer cell

Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.

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Neuropilin

Neuropilin is a protein receptor active in neurons.

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Peripheral blood mononuclear cell

A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus.

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Psoriasis

Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin.

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RNA

Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.

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Systemic lupus erythematosus

Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.

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Tetherin

Tetherin, also known as bone marrow stromal antigen 2, is a lipid raft associated protein that in humans is encoded by the BST2 gene.

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TLR7

Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene.

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TLR9

Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene.

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Tumor necrosis factor alpha

Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.

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Redirects here:

Interferon Producing Cells, Interferon-producing cell, Interferon-producing cells, Plasmacytoid dendritic cells.

References

[1] https://en.wikipedia.org/wiki/Plasmacytoid_dendritic_cell

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