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71 relations: Active site, Adenosine diphosphate ribose, Allosteric regulation, Anaphase, Ankyrin repeat, Apoptosis-inducing factor, Aspartic acid, Base excision repair, Bond cleavage, Caspase, Cell (biology), Cell death, Cell nucleus, Chromatin, CTCF, Deoxyribose, DNA, DNA damage theory of aging, DNA ligase, DNA polymerase, DNA polymerase beta, DNA repair, DNA-binding domain, Enzyme kinetics, Genomic imprinting, Glucose, GLUT4, Glycine, GRB14, ICAM-1, In vitro, In vivo, Kilometre, Lymphoblast, Mad2, Maximum life span, MCL1, Mitosis, Nicotinamide, Nicotinamide adenine dinucleotide, Nuclear mitotic apparatus protein 1, PARG, PARP inhibitor, PARP1, PARP10, PARP12, PARP16, PARP2, PARP3, PARP4, ..., PARP8, Parthanatos, Polymer, Polymerization, Programmed cell death, Protein, Pyrophosphate, Senescence, Spindle apparatus, Spindle checkpoint, Structural motif, Telomere, TIPARP, TNKS, TNKS1BP1, TNKS2, TRF1, White blood cell, XRCC1, YY1, Zinc finger. Expand index (21 more) »
Active site
In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.
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Adenosine diphosphate ribose
Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase.
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Allosteric regulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
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Anaphase
Anaphase (from the Greek ἀνά, "up" and φάσις, "stage"), is the stage of mitosis after the metaphase when replicated chromosomes are split and the daughter chromatids are moved to opposite poles of the cell.
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Ankyrin repeat
The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch.
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Apoptosis-inducing factor
Apoptosis inducing factor is a flavoprotein.
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Aspartic acid
Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.
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Base excision repair
In biochemistry and genetics, base excision repair (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle.
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Bond cleavage
Bond cleavage, or scission, is the splitting of chemical bonds.
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Caspase
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.
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Cell (biology)
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
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Cell death
Cell death is the event of a biological cell ceasing to carry out its functions.
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Cell nucleus
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
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Chromatin
Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.
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CTCF
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene.
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Deoxyribose
Deoxyribose, or more precisely 2-deoxyribose, is a monosaccharide with idealized formula H−(C.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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DNA damage theory of aging
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damages.
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DNA ligase
DNA ligase is a specific type of enzyme, a ligase, that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond.
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DNA polymerase
DNA polymerases are enzymes that synthesize DNA molecules from deoxyribonucleotides, the building blocks of DNA.
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DNA polymerase beta
DNA polymerase, beta, also known as POLB, is an enzyme present in eukaryotes.
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DNA repair
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
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DNA-binding domain
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.
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Enzyme kinetics
Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes.
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Genomic imprinting
Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed in a parent-of-origin-specific manner.
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Glucose
Glucose is a simple sugar with the molecular formula C6H12O6.
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GLUT4
Glucose transporter type 4 (GLUT-4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene.
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Glycine
Glycine (symbol Gly or G) is the amino acid that has a single hydrogen atom as its side chain.
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GRB14
Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.
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ICAM-1
ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene.
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In vitro
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Kilometre
The kilometre (International spelling as used by the International Bureau of Weights and Measures; SI symbol: km; or) or kilometer (American spelling) is a unit of length in the metric system, equal to one thousand metres (kilo- being the SI prefix for). It is now the measurement unit used officially for expressing distances between geographical places on land in most of the world; notable exceptions are the United States and the road network of the United Kingdom where the statute mile is the official unit used.
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Lymphoblast
A lymphoblast is a modified naive lymphocyte that also looks completely different.
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Mad2
Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein.
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Maximum life span
Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death.
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MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.
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Mitosis
In cell biology, mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei.
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Nicotinamide
Nicotinamide (NAA), also known as niacinamide, is a form of vitamin B3 found in food and used as a dietary supplement and medication.
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Nicotinamide adenine dinucleotide
Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.
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Nuclear mitotic apparatus protein 1
Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.
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PARG
Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.
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PARP inhibitor
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP).
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PARP1
Poly polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly synthase 1 is an enzyme that in humans is encoded by the PARP1 gene.
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PARP10
Poly polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.
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PARP12
Poly polymerase 12 is an enzyme that in humans is encoded by the PARP12 gene.
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PARP16
Poly (ADP-ribose) polymerase family, member 16 is a protein in humans that is encoded by the PARP16 gene.
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PARP2
Poly polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene.
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PARP3
Poly polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.
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PARP4
Poly polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.
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PARP8
Poly polymerase 8 is an enzyme that in humans is encoded by the PARP8 gene.
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Parthanatos
Parthanatos (derived from the Greek Θάνατος, "Death") is a form of programmed cell death that is distinct from other cell death processes such as necrosis and apoptosis.
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Polymer
A polymer (Greek poly-, "many" + -mer, "part") is a large molecule, or macromolecule, composed of many repeated subunits.
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Polymerization
In polymer chemistry, polymerization is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks.
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Programmed cell death
Programmed cell death (or PCD) is the death of a cell in any form, mediated by an intracellular program.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Pyrophosphate
In chemistry, a pyrophosphate is a phosphorus oxyanion.
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Senescence
Senescence or biological ageing is the gradual deterioration of function characteristic of most complex lifeforms, arguably found in all biological kingdoms, that on the level of the organism increases mortality after maturation.
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Spindle apparatus
In cell biology, the spindle apparatus (or mitotic spindle) refers to the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.
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Spindle checkpoint
During the process of cell division, the spindle checkpoint prevents separation of the duplicated chromosomes until each chromosome is properly attached to the spindle apparatus.
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Structural motif
In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.
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Telomere
A telomere is a region of repetitive nucleotide sequences at each end of a chromosome, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes.
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TIPARP
TCDD-inducible poly polymerase is an enzyme that in humans is encoded by the TIPARP gene.
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TNKS
Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.
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TNKS1BP1
182 kDa tankyrase-1-binding protein is an enzyme that in humans is encoded by the TNKS1BP1 gene.
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TNKS2
Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.
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TRF1
The Tr-F1 is a 155mm French towed howitzer produced by Nexter (ex Giat Industries) and used by the French army.
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White blood cell
White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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XRCC1
DNA repair protein XRCC1 also known as X-ray repair cross-complementing protein 1 is a protein that in humans is encoded by the XRCC1 gene.
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YY1
YY1 (Yin Yang 1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene.
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Zinc finger
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold.
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Redirects here:
EC 2.4.2.30, NAD+ ADP-ribosyltransferase, NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase, Poly ADP ribose polymerase, Poly adp ribose polymerase, Poly(ADP-ribose) polymerase-1, Poly(adp-ribose) polymerases.
References
[1] https://en.wikipedia.org/wiki/Poly_(ADP-ribose)_polymerase
