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Polyclonal B cell response

Index Polyclonal B cell response

Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. [1]

138 relations: Active immunization, Adaptive immune system, Affinity maturation, Antibody, Antibody-dependent cell-mediated cytotoxicity, Antigen, Antigen presentation, Antigen processing, Antigen-presenting cell, Antiserum, Atom, Autoimmunity, B cell, B-cell receptor, B7 (protein), Bacteria, Basophil, CD154, CD28, CD3 (immunology), CD40 (protein), Cell (biology), Cell division, Cell growth, Cell membrane, Cell-mediated immunity, Cellular differentiation, Clonal selection, Clone (B-cell biology), Clone (cell biology), Cluster of differentiation, Co-stimulation, Colonization, Complement system, David Talmage, Denaturation (biochemistry), Dendritic cell, Dengue fever, Differential centrifugation, Diphtheria, Disulfide, DNA, Elvin A. Kabat, Emil von Behring, Enzyme, Eosinophil, Epitope, Fibrinogen, Frank Macfarlane Burnet, Gamma globulin, ..., Gene, Gnathostomata, Gustav Nossal, Haplotype, HIV, Host (biology), Human leukocyte antigen, Humoral immunity, Hydrogen, Immune receptor, Immune system, Immunofluorescence, Immunologic activation, Infection, Innate immune system, Inoculation, Interleukin, Interleukin 2, Interleukin 4, Interleukin 5, Interleukin 6, Karolinska Institute, Kitasato Shibasaburō, Ligand (biochemistry), Linear epitope, Lymph node, Lymphocyte, Lysosome, Macrophage, Major histocompatibility complex, Mammal, Medical sign, Memory B cell, Merrill Chase, MHC class I, MHC class II, Microorganism, Molecular mimicry, Molecular recognition, Monoclonal antibody, Monoclonal antibody therapy, Monocyte, Multiple myeloma, Mutation, Myoglobin, Natural selection, Neoplasm, Neutrophil, Niels Kaj Jerne, Nobel Prize, Non-covalent interactions, Opsonin, Optical microscope, Organ (anatomy), Organ transplantation, Original antigenic sin, Orthomyxoviridae, Paracrine signalling, Paratope, Pathogen, Pattern recognition receptor, Paul Ehrlich, Peptide, Peter C. Doherty, Phagocytosis, Phagosome, Pinocytosis, Plasma cell, Pneumonia, Polyclonal antibodies, Protease, Protein, Redox, Rolf M. Zinkernagel, Salmonella enterica subsp. enterica, Somatic hypermutation, Staining, Symptom, T cell, T helper cell, Tissue (biology), Toll-like receptor, Toxin, Tuberculosis, Typhoid fever, Virus, Western blot, White blood cell. Expand index (88 more) »

Active immunization

Active immunization is the induction of immunity after exposure to an antigen.

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Adaptive immune system

The adaptive immune system, also known as the acquired immune system or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate pathogens or prevent their growth.

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Affinity maturation

In immunology, affinity maturation is the process by which Tfh cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Antibody-dependent cell-mediated cytotoxicity

The antibody-dependent cell-mediated cytotoxicity (ADCC), also referred to as antibody-dependent cellular cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector cell of the immune system actively lyses a target cell, whose membrane-surface antigens have been bound by specific antibodies.

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Antigen

In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.

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Antigen presentation

Antigen presentation describes a vital immune process which is essential for T cell immune response triggering.

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Antigen processing

Antigen processing is an immunological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes.

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Antigen-presenting cell

An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen complexed with major histocompatibility complexes (MHCs) on their surfaces; this process is known as antigen presentation.

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Antiserum

Antiserum (plural: antisera) is human or nonhuman blood serum containing polyclonal antibodies and is used to pass on passive immunity to many diseases.

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Atom

An atom is the smallest constituent unit of ordinary matter that has the properties of a chemical element.

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Autoimmunity

Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues.

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B cell

B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.

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B-cell receptor

The B-cell receptor or BCR is composed of immunoglobulin molecules that form a type 1 transmembrane receptor protein usually located on the outer surface of a lymphocyte type known as B cells.

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B7 (protein)

B7 is a type of peripheral membrane protein found on activated antigen presenting cells (APC) that, when paired with either a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively.

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Bacteria

Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.

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Basophil

Basophils are a type of white blood cells.

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CD154

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules.

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CD28

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival.

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CD3 (immunology)

In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells).

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CD40 (protein)

Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell division

Cell division is the process by which a parent cell divides into two or more daughter cells.

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Cell growth

The term cell growth is used in the contexts of biological cell development and cell division (reproduction).

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Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).

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Cell-mediated immunity

Cell-mediated immunity is an immune response that does not involve antibodies, but rather involves the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Clonal selection

Clonal selection theory is a scientific theory in immunology that explains the functions of cells (lymphocytes) of the immune system in response to specific antigens invading the body.

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Clone (B-cell biology)

The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity.

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Clone (cell biology)

A clone is a group of identical cells that share a common ancestry, meaning they are derived from the same cell.

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Cluster of differentiation

The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.

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Co-stimulation

During the activation of lymphocytes, co-stimulation is often crucial to the development of an effective immune response.

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Colonization

Colonization (or colonisation) is a process by which a central system of power dominates the surrounding land and its components.

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Complement system

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's cell membrane.

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David Talmage

David Wilson Talmage (September 15, 1919 – March 6, 2014) was an American immunologist.

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Denaturation (biochemistry)

Denaturation is a process in which proteins or nucleic acids lose the quaternary structure, tertiary structure, and secondary structure which is present in their native state, by application of some external stress or compound such as a strong acid or base, a concentrated inorganic salt, an organic solvent (e.g., alcohol or chloroform), radiation or heat.

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Dendritic cell

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.

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Dengue fever

Dengue fever is a mosquito-borne tropical disease caused by the dengue virus.

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Differential centrifugation

Differential centrifugation is a common procedure in microbiology and cytology used to separate certain organelles from whole cells for further analysis of specific parts of cells.

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Diphtheria

Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae.

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Disulfide

In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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Elvin A. Kabat

Elvin Abraham Kabat (September 1, 1914 – June 16, 2000) was an American biomedical scientist and one of the founding fathers of modern quantitative immunochemistry.

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Emil von Behring

Emil von Behring (Emil Adolf von Behring), born as Emil Adolf Behring (15 March 1854 – 31 March 1917), was a German physiologist who received the 1901 Nobel Prize in Physiology or Medicine, the first one awarded, for his discovery of a diphtheria antitoxin.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Eosinophil

Eosinophils sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply. These cells are eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes: Normally transparent, it is this affinity that causes them to appear brick-red after staining with eosin, a red dye, using the Romanowsky method. The staining is concentrated in small granules within the cellular cytoplasm, which contain many chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite and host tissues. In normal individuals, eosinophils make up about 1–3% of white blood cells, and are about 12–17 micrometres in size with bilobed nuclei. While they are released into the bloodstream as neutrophils are, eosinophils reside in tissue They are found in the medulla and the junction between the cortex and medulla of the thymus, and, in the lower gastrointestinal tract, ovary, uterus, spleen, and lymph nodes, but not in the lung, skin, esophagus, or some other internal organs under normal conditions. The presence of eosinophils in these latter organs is associated with disease. For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments.

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Epitope

An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells.

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Fibrinogen

Fibrinogen (factor I) is a glycoprotein that in vertebrates circulates in the blood.

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Frank Macfarlane Burnet

Sir Frank Macfarlane Burnet, (3 September 1899 – 31 August 1985), usually known as Macfarlane or Mac Burnet, was an Australian virologist best known for his contributions to immunology.

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Gamma globulin

Gamma globulins are a class of globulins, identified by their position after serum protein electrophoresis.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gnathostomata

Gnathostomata are the jawed vertebrates.

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Gustav Nossal

Sir Gustav Victor Joseph Nossal,, FRS (born 4 June 1931) is a distinguished Australian research biologist.

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Haplotype

A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent.

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HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

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Host (biology)

In biology and medicine, a host is an organism that harbours a parasitic, a mutualistic, or a commensalist guest (symbiont), the guest typically being provided with nourishment and shelter.

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Human leukocyte antigen

The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans.

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Humoral immunity

Humoral immunity or humoural immunity is the aspect of immunity that is mediated by macromolecules found in extracellular fluids such as secreted antibodies, complement proteins, and certain antimicrobial peptides.

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Hydrogen

Hydrogen is a chemical element with symbol H and atomic number 1.

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Immune receptor

An immune receptor (or immunologic receptor) is a receptor, usually on a cell membrane, which binds to a substance (for example, a cytokine) and causes a response in the immune system.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Immunofluorescence

Immunofluorescence is a technique used for light microscopy with a fluorescence microscope and is used primarily on microbiological samples.

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Immunologic activation

In immunology, activation is the transition of leucocytes and other cell types involved in the immune system.

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Infection

Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.

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Innate immune system

The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.

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Inoculation

The terms inoculation, vaccination and immunization are often used synonymously to refer to artificial induction of immunity against various infectious diseases.

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Interleukin

Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that were first seen to be expressed by white blood cells (leukocytes).

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Interleukin 2

Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.

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Interleukin 4

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells.

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Interleukin 5

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells.

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Interleukin 6

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.

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Karolinska Institute

The Karolinska Institute (KI; Karolinska Institutet; sometimes known as the (Royal) Caroline Institute in English) is a medical university in Solna within the Stockholm urban area of Sweden.

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Kitasato Shibasaburō

Baron was a Japanese physician and bacteriologist during the reign of the Empire of Japan, prior to World War 2.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Linear epitope

A linear or a sequential epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or primary structure.

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Lymph node

A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Lysosome

A lysosome is a membrane-bound organelle found in nearly all animal cells.

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Macrophage

Macrophages (big eaters, from Greek μακρός (makrós).

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Major histocompatibility complex

The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.

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Mammal

Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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Medical sign

A medical sign is an objective indication of some medical fact or characteristic that may be detected by a patient or anyone, especially a physician, before or during a physical examination of a patient.

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Memory B cell

Memory B cells are a B cell sub-type that are formed within germinal centers following primary infection and are important in generating an accelerated and more robust antibody-mediated immune response in the case of re-infection (also known as a secondary immune response).

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Merrill Chase

Merrill W. Chase (September 17, 1905 – January 5, 2004) was an immunologist working at the Rockefeller University in New York City who is credited with discovering cell-mediated immunology in the early 1940s.

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MHC class I

MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates.

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MHC class II

MHC class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells.

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Microorganism

A microorganism, or microbe, is a microscopic organism, which may exist in its single-celled form or in a colony of cells. The possible existence of unseen microbial life was suspected from ancient times, such as in Jain scriptures from 6th century BC India and the 1st century BC book On Agriculture by Marcus Terentius Varro. Microbiology, the scientific study of microorganisms, began with their observation under the microscope in the 1670s by Antonie van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera and anthrax. Microorganisms include all unicellular organisms and so are extremely diverse. Of the three domains of life identified by Carl Woese, all of the Archaea and Bacteria are microorganisms. These were previously grouped together in the two domain system as Prokaryotes, the other being the eukaryotes. The third domain Eukaryota includes all multicellular organisms and many unicellular protists and protozoans. Some protists are related to animals and some to green plants. Many of the multicellular organisms are microscopic, namely micro-animals, some fungi and some algae, but these are not discussed here. They live in almost every habitat from the poles to the equator, deserts, geysers, rocks and the deep sea. Some are adapted to extremes such as very hot or very cold conditions, others to high pressure and a few such as Deinococcus radiodurans to high radiation environments. Microorganisms also make up the microbiota found in and on all multicellular organisms. A December 2017 report stated that 3.45 billion year old Australian rocks once contained microorganisms, the earliest direct evidence of life on Earth. Microbes are important in human culture and health in many ways, serving to ferment foods, treat sewage, produce fuel, enzymes and other bioactive compounds. They are essential tools in biology as model organisms and have been put to use in biological warfare and bioterrorism. They are a vital component of fertile soils. In the human body microorganisms make up the human microbiota including the essential gut flora. They are the pathogens responsible for many infectious diseases and as such are the target of hygiene measures.

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides.

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Molecular recognition

The term molecular recognition refers to the specific interaction between two or more molecules through noncovalent bonding such as hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, π-π interactions, halogen bonding, electrostatic and/or electromagnetic effects.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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Monoclonal antibody therapy

Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAb) to bind monospecifically to certain cells or proteins.

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Monocyte

Monocytes are a type of leukocyte, or white blood cell.

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Multiple myeloma

Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Myoglobin

Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals.

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Natural selection

Natural selection is the differential survival and reproduction of individuals due to differences in phenotype.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Neutrophil

Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.

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Niels Kaj Jerne

Niels Kaj Jerne, FRS (23 December 1911 – 7 October 1994) was a Danish immunologist.

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Nobel Prize

The Nobel Prize (Swedish definite form, singular: Nobelpriset; Nobelprisen) is a set of six annual international awards bestowed in several categories by Swedish and Norwegian institutions in recognition of academic, cultural, or scientific advances.

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Non-covalent interactions

A non-covalent interaction differs from a covalent bond in that it does not involve the sharing of electrons, but rather involves more dispersed variations of electromagnetic interactions between molecules or within a molecule.

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Opsonin

An opsonin (from the Greek opsōneîn, to prepare for eating) is any molecule that enhances phagocytosis by marking an antigen for an immune response or marking dead cells for recycling (i.e., causes the phagocyte to "relish" the marked cell).

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Optical microscope

The optical microscope, often referred to as the light microscope, is a type of microscope that uses visible light and a system of lenses to magnify images of small subjects.

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Organ (anatomy)

Organs are collections of tissues with similar functions.

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Organ transplantation

Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ.

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Original antigenic sin

Original antigenic sin, also known as the Hoskins effect, refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign entity (e.g. a virus or bacterium) is encountered.

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Orthomyxoviridae

The Orthomyxoviruses (ὀρθός, orthós, Greek for "straight"; μύξα, mýxa, Greek for "mucus") are a family of RNA viruses that includes seven genera: Influenza virus A, Influenza virus B, Influenza virus C, Influenza virus D, Isavirus, Thogotovirus and Quaranjavirus.

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Paracrine signalling

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.

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Paratope

A paratope, also called an antigen-binding site, is a part of an antibody which recognizes and binds to an antigen.

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Pathogen

In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.

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Pattern recognition receptor

Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system.

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Paul Ehrlich

Paul Ehrlich (14 March 1854 – 20 August 1915) was a German Jewish physician and scientist who worked in the fields of hematology, immunology, and antimicrobial chemotherapy.

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Peptide

Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

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Peter C. Doherty

Peter Charles Doherty, (born 15 October 1940) is an Australian veterinary surgeon and researcher in the field of medicine.

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Phagocytosis

In cell biology, phagocytosis is the process by which a cell—often a phagocyte or a protist—engulfs a solid particle to form an internal compartment known as a phagosome.

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Phagosome

In cell biology, a phagosome is a vesicle formed around a particle engulfed by a phagocyte via phagocytosis.

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Pinocytosis

In cellular biology, pinocytosis, otherwise known as fluid endocytosis and bulk-phase pinocytosis, is a mode of endocytosis in which small particles suspended in extracellular fluid are brought into the cell through an invagination of the cell membrane, resulting in a suspension of the particles within a small vesicle inside the cell.

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Plasma cell

Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies.

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Pneumonia

Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli.

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Polyclonal antibodies

Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage).

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Protease

A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Rolf M. Zinkernagel

Rolf Martin Zinkernagel (born January 6, 1944) is Professor of Experimental Immunology at the University of Zurich.

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Salmonella enterica subsp. enterica

Salmonella enterica subsp.

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Somatic hypermutation

Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), as seen during class switching.

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Staining

Staining is an auxiliary technique used in microscopy to enhance contrast in the microscopic image.

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Symptom

A symptom (from Greek σύμπτωμα, "accident, misfortune, that which befalls", from συμπίπτω, "I befall", from συν- "together, with" and πίπτω, "I fall") is a departure from normal function or feeling which is noticed by a patient, reflecting the presence of an unusual state, or of a disease.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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T helper cell

The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.

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Tissue (biology)

In biology, tissue is a cellular organizational level between cells and a complete organ.

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Toll-like receptor

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.

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Toxin

A toxin (from toxikon) is a poisonous substance produced within living cells or organisms; synthetic toxicants created by artificial processes are thus excluded.

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Tuberculosis

Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB).

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Typhoid fever

Typhoid fever, also known simply as typhoid, is a bacterial infection due to ''Salmonella'' typhi that causes symptoms.

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Virus

A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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Western blot

The western blot (sometimes called the protein immunoblot) is a widely used analytical technique used in molecular biology, immunogenetics and other molecular biology disciplines to detect specific proteins in a sample of tissue homogenate or extract.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Redirects here:

Polyclonal, Polyclonal immune response, Polyclonal response, Polyclonal response/Archive 1, Polyclonal response/Discussion of difficult terms, Polyclonal response/GA2.

References

[1] https://en.wikipedia.org/wiki/Polyclonal_B_cell_response

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