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36 relations: Birth defect, Bortezomib, Capsule (pharmacy), Celgene, Condom, CYP1A2, CYP2C19, CYP2D6, CYP3A4, Derivative (chemistry), Development of analogs of thalidomide, Dexamethasone, Downregulation and upregulation, European Commission, European Union, Food and Drug Administration, Immunotherapy, Interferon gamma, Interleukin 10, Interleukin 2, Interleukin 6, International nonproprietary name, Lenalidomide, Liver, Multiple myeloma, Myelofibrosis, P-value, Pentoxifylline, Progression-free survival, Rolipram, Semen, Sperm donation, Survival rate, Thalidomide, TNF inhibitor, Vasectomy.
Birth defect
A birth defect, also known as a congenital disorder, is a condition present at birth regardless of its cause.
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Bortezomib
Bortezomib (BAN, INN and USAN; marketed as Velcade by Takeda Oncology; Chemobort by Cytogen and Bortecad by Cadila Healthcare) is an anti-cancer drug and the first therapeutic proteasome inhibitor to be used in humans.
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Capsule (pharmacy)
In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories.
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Celgene
Celgene Corporation is an American biotechnology company that discovers, develops and commercializes medicines for cancer and inflammatory disorders.
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Condom
A condom is a sheath-shaped barrier device, used during sexual intercourse to reduce the probability of pregnancy or a sexually transmitted infection (STI).
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
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CYP2C19
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Derivative (chemistry)
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.
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Development of analogs of thalidomide
The development of analogs of thalidomide was precipitated by the discovery of the anti-angiogenic and anti-inflammatory properties of the drug yielding a new way of fighting cancer as well as some inflammatory diseases after it had been banned in 1961.
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Dexamethasone
Dexamethasone is a type of corticosteroid medication.
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Downregulation and upregulation
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus.
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European Commission
The European Commission (EC) is an institution of the European Union, responsible for proposing legislation, implementing decisions, upholding the EU treaties and managing the day-to-day business of the EU.
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European Union
The European Union (EU) is a political and economic union of EUnum member states that are located primarily in Europe.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Immunotherapy
Immunotherapy is the "treatment of disease by inducing, enhancing, or suppressing an immune response".
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Interferon gamma
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
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Interleukin 10
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.
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Interleukin 2
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.
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Interleukin 6
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Lenalidomide
Lenalidomide (trade name Revlimid) is a derivative of thalidomide introduced in 2004.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Multiple myeloma
Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.
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Myelofibrosis
Myelofibrosis, also known as osteomyelofibrosis, is a relatively rare bone marrow cancer.
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P-value
In statistical hypothesis testing, the p-value or probability value or asymptotic significance is the probability for a given statistical model that, when the null hypothesis is true, the statistical summary (such as the sample mean difference between two compared groups) would be the same as or of greater magnitude than the actual observed results.
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Pentoxifylline
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It is generic and sold under many brand names worldwide.Drugs.com. Page accessed Feb 1, 206.
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Progression-free survival
Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse".
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Rolipram
Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s.
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Semen
Semen, also known as seminal fluid, is an organic fluid that may contain spermatozoa.
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Sperm donation
Sperm donation is the provision (or "donation") by a man (known as a sperm donor) of his sperm (known as donor sperm), principally for it to be used in the artificial insemination of a woman or women who are not his sexual partners.
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Survival rate
Survival rate is a part of survival analysis.
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Thalidomide
Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs.
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TNF inhibitor
A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.
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Vasectomy
Vasectomy is a surgical procedure for male sterilization or permanent contraception.
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Redirects here:
ATC code L04AX06, ATCvet code QL04AX06, Actimid, CC-4047, Imnovid, Pomalyst.
References
[1] https://en.wikipedia.org/wiki/Pomalidomide
