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Pregnanolone

Index Pregnanolone

Pregnanolone, also known as eltanolone, is an endogenous inhibitory neurosteroid which is produced in the body from progesterone. [1]

Table of Contents

  1. 36 relations: Allopregnanolone, Allosteric modulator, Anesthesia, Anesthetic, Anticonvulsant, Anxiolytic, Biological activity, Biological half-life, Convulsion, Derivative (chemistry), Endogeny (biology), Enzyme, Epipregnanolone, Fetus, GABAA receptor, General anaesthetic, Glycine receptor, Hydroxydione, Inhibitory postsynaptic potential, Intravenous therapy, Isopregnanolone, Metabolic intermediate, Natural product, Neurosteroid, Pregnancy, Pregnane, Progesterone, Renanolone, Sedation, Sedative, Side effect, Steroid, Urine, 3α-Hydroxysteroid dehydrogenase, 5β-Dihydroprogesterone, 5β-Reductase.

  2. 5β-Pregnanes
  3. GABAA-rho receptor negative allosteric modulators
  4. Pregnane X receptor agonists

Allopregnanolone

Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone. Pregnanolone and Allopregnanolone are GABAA receptor positive allosteric modulators, neurosteroids and pregnane X receptor agonists.

See Pregnanolone and Allopregnanolone

Allosteric modulator

In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.

See Pregnanolone and Allosteric modulator

Anesthesia

Anesthesia or anaesthesia is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes.

See Pregnanolone and Anesthesia

Anesthetic

An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness.

See Pregnanolone and Anesthetic

Anticonvulsant

Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.

See Pregnanolone and Anticonvulsant

Anxiolytic

An anxiolytic (also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety.

See Pregnanolone and Anxiolytic

Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

See Pregnanolone and Biological activity

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Pregnanolone and Biological half-life

Convulsion

A convulsion is a medical condition where the body muscles contract and relax rapidly and repeatedly, resulting in uncontrolled shaking.

See Pregnanolone and Convulsion

Derivative (chemistry)

In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.

See Pregnanolone and Derivative (chemistry)

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

See Pregnanolone and Endogeny (biology)

Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

See Pregnanolone and Enzyme

Epipregnanolone

Epipregnanolone, also known as 3β-hydroxy-5β-pregnan-20-one, 3β,5β-tetrahydroprogesterone, or 3β,5β-THP, is an endogenous neurosteroid. Pregnanolone and Epipregnanolone are 5β-Pregnanes and neurosteroids.

See Pregnanolone and Epipregnanolone

Fetus

A fetus or foetus (fetuses, foetuses, rarely feti or foeti) is the unborn offspring that develops from a mammal embryo.

See Pregnanolone and Fetus

GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

See Pregnanolone and GABAA receptor

General anaesthetic

General anaesthetics (or anesthetics) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals.

See Pregnanolone and General anaesthetic

Glycine receptor

The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine.

See Pregnanolone and Glycine receptor

Hydroxydione

Hydroxydione, as hydroxydione sodium succinate (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients. Pregnanolone and hydroxydione are 5β-Pregnanes, GABAA receptor positive allosteric modulators, general anesthetics and neurosteroids.

See Pregnanolone and Hydroxydione

Inhibitory postsynaptic potential

An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential.

See Pregnanolone and Inhibitory postsynaptic potential

Intravenous therapy

Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.

See Pregnanolone and Intravenous therapy

Isopregnanolone

Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone, and as 3β-hydroxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone. Pregnanolone and Isopregnanolone are neurosteroids.

See Pregnanolone and Isopregnanolone

Metabolic intermediate

Metabolic intermediates are molecules that are the precursors or metabolites of biologically significant molecules.

See Pregnanolone and Metabolic intermediate

Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

See Pregnanolone and Natural product

Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Pregnanolone and Neurosteroid are neurosteroids.

See Pregnanolone and Neurosteroid

Pregnancy

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).

See Pregnanolone and Pregnancy

Pregnane

Pregnane, also known as 17β-ethylandrostane or as 10β,13β-dimethyl-17β-ethylgonane, is a C21 steroid and, indirectly, a parent of progesterone.

See Pregnanolone and Pregnane

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Pregnanolone and Progesterone are GABAA receptor positive allosteric modulators, glycine receptor antagonists, neurosteroids and pregnane X receptor agonists.

See Pregnanolone and Progesterone

Renanolone

Renanolone (INN), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a synthetic neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use. Pregnanolone and Renanolone are 5β-Pregnanes, GABAA receptor positive allosteric modulators, general anesthetics and neurosteroids.

See Pregnanolone and Renanolone

Sedation

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

See Pregnanolone and Sedation

Sedative

A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.

See Pregnanolone and Sedative

Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is unintended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

See Pregnanolone and Side effect

Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

See Pregnanolone and Steroid

Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

See Pregnanolone and Urine

3α-Hydroxysteroid dehydrogenase

3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme (1.1.1.50) that plays a role in the metabolism of steroids and non-steroidal compounds in humans and other species, such as bacteria, fungi, plants, and so on.

See Pregnanolone and 3α-Hydroxysteroid dehydrogenase

5β-Dihydroprogesterone

5β-Dihydroprogesterone (5β-DHP, pregnanedione, or 5β-pregnane-3,20-dione) is an endogenous neurosteroid and an intermediate in the biosynthesis of pregnanolone and epipregnanolone from progesterone. Pregnanolone and 5β-Dihydroprogesterone are 5β-Pregnanes, GABAA receptor positive allosteric modulators, GABAA-rho receptor negative allosteric modulators, neurosteroids and pregnane X receptor agonists.

See Pregnanolone and 5β-Dihydroprogesterone

5β-Reductase

5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.

See Pregnanolone and 5β-Reductase

See also

5β-Pregnanes

GABAA-rho receptor negative allosteric modulators

Pregnane X receptor agonists

References

[1] https://en.wikipedia.org/wiki/Pregnanolone

Also known as Eltanolone.